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Histological chorioamnionitis shapes the neonatal transcriptomic immune response.
Weitkamp JH, Guthrie SO, Wong HR, Moldawer LL, Baker HV, Wynn JL. Weitkamp JH, et al. Early Hum Dev. 2016 Jul;98:1-6. doi: 10.1016/j.earlhumdev.2016.06.001. Epub 2016 Jun 16. Early Hum Dev. 2016. PMID: 27318328 Free PMC article.
BACKGROUND: Histologic chorioamnionitis (HCA) is commonly associated with preterm birth and deleterious post-natal outcomes including sepsis and necrotizing enterocolitis. ...CONCLUSIONS: Exposure to HCA distinctively activates the neonatal immune system in utero with pote …
BACKGROUND: Histologic chorioamnionitis (HCA) is commonly associated with preterm birth and deleterious post-natal outcomes including …
Time for a neonatal-specific consensus definition for sepsis.
Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA. Wynn JL, et al. Pediatr Crit Care Med. 2014 Jul;15(6):523-8. doi: 10.1097/PCC.0000000000000157. Pediatr Crit Care Med. 2014. PMID: 24751791 Free PMC article. Review.
OBJECTIVE: To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of neonatal sepsis used. ...Thus, specific consensus definitions for both term and preterm neonates are needed. Such definitions are cr …
OBJECTIVE: To review the accuracy of the pediatric consensus definition of sepsis in term neonates and to determine the definition of …
Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis.
Slinko S, Piraino G, Hake PW, Ledford JR, O'Connor M, Lahni P, Solan PD, Wong HR, Zingarelli B. Slinko S, et al. Shock. 2014 Apr;41(4):292-300. doi: 10.1097/SHK.0000000000000127. Shock. 2014. PMID: 24430544 Free PMC article.
These beneficial effects were associated with restored lung nuclear expression of PPARgamma and reduction of phosphorylated extracellular signal-regulated kinases 1 and 2 and nuclear factor kappaB activities in comparison to vehicle or single treatment protocols. Our data demonst …
These beneficial effects were associated with restored lung nuclear expression of PPARgamma and reduction of phosphorylated extracellular si …
Pediatric sepsis: challenges and adjunctive therapies.
Hanna W, Wong HR. Hanna W, et al. Crit Care Clin. 2013 Apr;29(2):203-22. doi: 10.1016/j.ccc.2012.11.003. Epub 2013 Jan 3. Crit Care Clin. 2013. PMID: 23537672 Free PMC article. Review.
This review provides an appraisal of adjunctive therapies for sepsis and highlights opportunities for meeting selected challenges in the field. Future clinical studies should address long-term and functional outcomes as well as acute outcomes. Potential adjunctive therapie …
This review provides an appraisal of adjunctive therapies for sepsis and highlights opportunities for meeting selected challenges in the fie …