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2009 2
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Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers.
Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ, Court MH. Volak LP, et al. Br J Clin Pharmacol. 2013 Feb;75(2):450-62. doi: 10.1111/j.1365-2125.2012.04364.x. Br J Clin Pharmacol. 2013. PMID: 22725836 Free PMC article. Clinical Trial.
Although curcuminoid and piperine concentrations were readily measured in plasma following glucuronidase/sulfatase treatment, unconjugated concentrations were consistently below the assay thresholds (0.05-0.08 muM and 0.6 muM, respectively). CONCLUSION: The results indicate that …
Although curcuminoid and piperine concentrations were readily measured in plasma following glucuronidase/sulfatase treatment, unconjugated c …
Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase.
Greenblatt DJ, Peters DE, Oleson LE, Harmatz JS, MacNab MW, Berkowitz N, Zinny MA, Court MH. Greenblatt DJ, et al. Br J Clin Pharmacol. 2009 Dec;68(6):920-7. doi: 10.1111/j.1365-2125.2009.03545.x. Br J Clin Pharmacol. 2009. PMID: 20002087 Free PMC article. Clinical Trial.
. * ALT-2074, a catalytic mimic of glutathione oxidase, inhibits human cytochrome P450 3A (CYP3A) isoforms in vitro. WHAT THIS STUDY ADDS: * Short-term administration of low-dose ritonavir increases area under the plasma concentration curve following oral midazolam by a fa …
. * ALT-2074, a catalytic mimic of glutathione oxidase, inhibits human cytochrome P450 3A (CYP3A) isoforms in vitro. WHAT THIS STUDY ADDS: * …
Effects of dietary soy isoflavones on health, steroidogenesis, and thyroid gland function in dogs.
Cerundolo R, Michel KE, Court MH, Shrestha B, Refsal KR, Oliver JW, Biourge V, Shofer FS. Cerundolo R, et al. Am J Vet Res. 2009 Mar;70(3):353-60. doi: 10.2460/ajvr.70.3.353. Am J Vet Res. 2009. PMID: 19254147 Free PMC article. Clinical Trial.
CONCLUSIONS AND CLINICAL RELEVANCE: Phytoestrogens may influence endocrine function in dogs. Feeding soy to dogs on a long-term basis may influence results of studies in which endocrine function is evaluated, although larger studies are needed to confirm this supposition.. …
CONCLUSIONS AND CLINICAL RELEVANCE: Phytoestrogens may influence endocrine function in dogs. Feeding soy to dogs on a long-term basis …