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Complex I subunit gene therapy with NDUFA6 ameliorates neurodegeneration in EAE.
Talla V, Koilkonda R, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Guy J. Talla V, et al. Invest Ophthalmol Vis Sci. 2015 Jan 22;56(2):1129-40. doi: 10.1167/iovs.14-15950. Invest Ophthalmol Vis Sci. 2015. PMID: 25613946 Free PMC article.
Overexpression of NDUFA6Flag in the visual system of EAE mice rescued retinal complex I activity completely, axonal loss by 73%, and retinal ganglion cell (RGC) loss by 88%, RGC apoptosis by 66%, and restored the 33% loss of complex I activity in EAE to normal levels; thereby, pr …
Overexpression of NDUFA6Flag in the visual system of EAE mice rescued retinal complex I activity completely, axonal loss by 73%, and retinal …
Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.
Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, MacNicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW. Howell GR, et al. J Clin Invest. 2012 Apr;122(4):1246-61. doi: 10.1172/JCI61135. Epub 2012 Mar 19. J Clin Invest. 2012. PMID: 22426214 Free PMC article.
A single x-ray treatment of an individual eye in young mice provided that eye with long-term protection from glaucoma but had no effect on the contralateral eye. ...
A single x-ray treatment of an individual eye in young mice provided that eye with long-term protection from glaucoma but had no effe …