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Page 1
Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets.
Yang J, Bruun DA, Wang C, Wan D, McReynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD. Yang J, et al. Toxicol Appl Pharmacol. 2019 Nov 1;382:114749. doi: 10.1016/j.taap.2019.114749. Epub 2019 Sep 12. Toxicol Appl Pharmacol. 2019. PMID: 31521729 Free PMC article.
The classical atropine/2-PAM antidote fails to protect against long-term symptoms following acute intoxication with OPs at levels that trigger status epilepticus. Acute OP intoxication also causes a robust neuroinflammatory response, which is implicated in the pathogenesis …
The classical atropine/2-PAM antidote fails to protect against long-term symptoms following acute intoxication with OPs at levels tha …
Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.
Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP. Panigrahy D, et al. J Clin Invest. 2019 Jun 17;129(7):2964-2979. doi: 10.1172/JCI127282. eCollection 2019 Jun 17. J Clin Invest. 2019. PMID: 31205032 Free PMC article.
Preoperative, but not postoperative, administration of the nonsteroidal antiinflammatory drug ketorolac and/or resolvins, a family of specialized proresolving autacoid mediators, eliminated micrometastases in multiple tumor-resection models, resulting in long-term survival …
Preoperative, but not postoperative, administration of the nonsteroidal antiinflammatory drug ketorolac and/or resolvins, a family of specia …
Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation.
Kodani SD, Morisseau C. Kodani SD, et al. Biochimie. 2019 Apr;159:59-65. doi: 10.1016/j.biochi.2019.01.020. Epub 2019 Feb 1. Biochimie. 2019. PMID: 30716359 Free PMC article. Review.
However, unresolved and chronic neuroinflammation can lead to long term damage and eventually neurologic disease including Parkinson's disease, Alzheimer's disease and dementia. Recently, enhancing the concentration of epoxyeicosatrienoic acids (EETs) through blocking thei …
However, unresolved and chronic neuroinflammation can lead to long term damage and eventually neurologic disease including Parkinson' …
Lipidomic Analysis of Oxidized Fatty Acids in Plant and Algae Oils.
Richardson CE, Hennebelle M, Otoki Y, Zamora D, Yang J, Hammock BD, Taha AY. Richardson CE, et al. J Agric Food Chem. 2017 Mar 8;65(9):1941-1951. doi: 10.1021/acs.jafc.6b05559. Epub 2017 Feb 28. J Agric Food Chem. 2017. PMID: 28157307 Free PMC article.
The change in oxylipin concentrations was not significantly different among the oils after short-term heating. The estimated oxylipin intake from nonheated soybean, canola, corn, and olive oil was 1.1 mg per person per day. These findings suggest that oils represent a diet …
The change in oxylipin concentrations was not significantly different among the oils after short-term heating. The estimated oxylipin …
Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury.
Akhnokh MK, Yang FH, Samokhvalov V, Jamieson KL, Cho WJ, Wagg C, Takawale A, Wang X, Lopaschuk GD, Hammock BD, Kassiri Z, Seubert JM. Akhnokh MK, et al. Front Pharmacol. 2016 Jun 7;7:133. doi: 10.3389/fphar.2016.00133. eCollection 2016. Front Pharmacol. 2016. PMID: 27375480 Free PMC article.
CONCLUSION: Inhibition or genetic deletion of sEH protects against long-term ischemia by preserving cardiac function and maintaining mitochondrial efficiency....
CONCLUSION: Inhibition or genetic deletion of sEH protects against long-term ischemia by preserving cardiac function and maintaining …
Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula.
Červenka L, Melenovský V, Husková Z, Sporková A, Bürgelová M, Škaroupková P, Hwang SH, Hammock BD, Imig JD, Sadowski J. Červenka L, et al. Physiol Res. 2015;64(6):857-73. doi: 10.33549/physiolres.932977. Epub 2015 Jun 5. Physiol Res. 2015. PMID: 26047375 Free PMC article.
Hence, renal dysfunction rather than cardiac remodeling determines long-term mortality in advanced stage of CHF due to volume overload. Strong protective actions of ACEi were associated with suppression of the vasoconstrictor/sodium retaining axis and activation of vasodil …
Hence, renal dysfunction rather than cardiac remodeling determines long-term mortality in advanced stage of CHF due to volume overloa …
The commonly used antimicrobial additive triclosan is a liver tumor promoter.
Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. Yueh MF, et al. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17200-5. doi: 10.1073/pnas.1419119111. Epub 2014 Nov 17. Proc Natl Acad Sci U S A. 2014. PMID: 25404284 Free PMC article.
These findings strongly suggest there are adverse health effects in mice with long-term TCS exposure, especially on enhancing liver fibrogenesis and tumorigenesis, and the relevance of TCS liver toxicity to humans should be evaluated....
These findings strongly suggest there are adverse health effects in mice with long-term TCS exposure, especially on enhancing liver f …
Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
Sporková A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L. Sporková A, et al. Clin Exp Pharmacol Physiol. 2014 Dec;41(12):1003-13. doi: 10.1111/1440-1681.12310. Clin Exp Pharmacol Physiol. 2014. PMID: 25224811 Free PMC article.
Recent studies have shown that the long-term antihypertensive action of soluble epoxide hydrolase inhibition (sEH) in angiotensin-II (AngII)-dependent hypertension might be mediated by the suppression of intrarenal AngII levels. ...Our findings show that the acute BP-lower …
Recent studies have shown that the long-term antihypertensive action of soluble epoxide hydrolase inhibition (sEH) in angiotensin-II …
Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA.
Schuchardt JP, Schneider I, Willenberg I, Yang J, Hammock BD, Hahn A, Schebb NH. Schuchardt JP, et al. Prostaglandins Other Lipid Mediat. 2014 Jun;109-111:23-31. doi: 10.1016/j.prostaglandins.2014.03.001. Epub 2014 Mar 22. Prostaglandins Other Lipid Mediat. 2014. PMID: 24667634 Free PMC article. Clinical Trial.
Taking the high biological activity of the EPA-derived epoxy fatty acids into account, even short-term treatment with LC n-3 PUFAs may cause systemic effects, which warrant further investigation....
Taking the high biological activity of the EPA-derived epoxy fatty acids into account, even short-term treatment with LC n-3 PUFAs ma …
14 results