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Practical Considerations for APOL1 Genotyping in the Living Kidney Donor Evaluation.
Mena-Gutierrez AM, Reeves-Daniel AM, Jay CL, Freedman BI. Mena-Gutierrez AM, et al. Transplantation. 2020 Jan;104(1):27-32. doi: 10.1097/TP.0000000000002933. Transplantation. 2020. PMID: 31449181 Free PMC article. Review.
RESULTS: Based on current data, transplant physicians should discuss APOL1 genotyping with potential living kidney donors self-reporting recent African ancestry. Until results from APOL1 Long-term Kidney Transplant Outcomes Network ancillary studies are available, we prese …
RESULTS: Based on current data, transplant physicians should discuss APOL1 genotyping with potential living kidney donors self-reporting rec …
Mechanisms of Injury in APOL1-associated Kidney Disease.
Ma L, Divers J, Freedman BI. Ma L, et al. Transplantation. 2019 Mar;103(3):487-492. doi: 10.1097/TP.0000000000002509. Transplantation. 2019. PMID: 30371607 Free PMC article. Review.
In the interim, the National Institutes of Health-sponsored "APOL1 Long-term Kidney Transplantation Outcomes" Network will determine whether APOL1 genotyping in individuals with recent African ancestry improves outcomes and safety in kidney transplantation....
In the interim, the National Institutes of Health-sponsored "APOL1 Long-term Kidney Transplantation Outcomes" Network will determine …
Hypertension-attributed nephropathy: what's in a name?
Freedman BI, Cohen AH. Freedman BI, et al. Nat Rev Nephrol. 2016 Jan;12(1):27-36. doi: 10.1038/nrneph.2015.172. Epub 2015 Nov 10. Nat Rev Nephrol. 2016. PMID: 26553514 Review.
Because genetic testing for APOL1 variants and other glomerulosclerosis-associated gene variants is available and can provide a precise definition of disease pathogenesis, we believe that the term 'hypertensive nephrosclerosis' should now be abandoned and replaced with eit …
Because genetic testing for APOL1 variants and other glomerulosclerosis-associated gene variants is available and can provide a precise defi …
APOL1 G1 genotype modifies the association between HDLC and kidney function in African Americans.
Bentley AR, Divers J, Shriner D, Doumatey AP, Gutiérrez OM, Adeyemo AA, Freedman BI, Rotimi CN. Bentley AR, et al. BMC Genomics. 2015 May 30;16(1):421. doi: 10.1186/s12864-015-1645-7. BMC Genomics. 2015. PMID: 26025194 Free PMC article.
The association between HDLC and eGFR was determined using linear mixed models, and the interaction between rs73885319 genotype and HDLC was evaluated using a multiplicative term. RESULTS: Among individuals homozygous for the risk genotype, a strong inverse HDLC-eGFR assoc …
The association between HDLC and eGFR was determined using linear mixed models, and the interaction between rs73885319 genotype and HDLC was …
Genotypic variation and outcomes in kidney transplantation: donor and recipient effects.
Gautreaux MD, Freedman BI. Gautreaux MD, et al. Kidney Int. 2013 Sep;84(3):431-3. doi: 10.1038/ki.2013.167. Kidney Int. 2013. PMID: 23989355 Free PMC article.
The genetic composition of a donor impacts long-term allograft survival after kidney transplantation. Effects of the recipient's genetic make-up, particularly variation in immune response pathway genes, are less certain. ...
The genetic composition of a donor impacts long-term allograft survival after kidney transplantation. Effects of the recipient's gene …
The impact of APOL1, CAV1, and ABCB1 gene variants on outcomes in kidney transplantation: donor and recipient effects.
Palanisamy A, Reeves-Daniel AM, Freedman BI. Palanisamy A, et al. Pediatr Nephrol. 2014 Sep;29(9):1485-92. doi: 10.1007/s00467-013-2531-7. Epub 2013 Jun 9. Pediatr Nephrol. 2014. PMID: 23748364 Free PMC article. Review.
Dramatic improvements have been seen in short-term kidney allograft survival over recent decades with introduction of more potent immunosuppressant medications and regimens. Unfortunately, improvements in long-term graft survival have lagged behind. The genomics rev …
Dramatic improvements have been seen in short-term kidney allograft survival over recent decades with introduction of more potent imm …
The APOL1 gene and allograft survival after kidney transplantation.
Reeves-Daniel AM, DePalma JA, Bleyer AJ, Rocco MV, Murea M, Adams PL, Langefeld CD, Bowden DW, Hicks PJ, Stratta RJ, Lin JJ, Kiger DF, Gautreaux MD, Divers J, Freedman BI. Reeves-Daniel AM, et al. Am J Transplant. 2011 May;11(5):1025-30. doi: 10.1111/j.1600-6143.2011.03513.x. Epub 2011 Apr 12. Am J Transplant. 2011. PMID: 21486385 Free PMC article.
If replicated, APOL1 genotyping could improve the donor selection process and maximize long-term renal allograft survival....
If replicated, APOL1 genotyping could improve the donor selection process and maximize long-term renal allograft survival....