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Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Ke J, Ma H, Gu X, Thelen A, Brunzelle JS, Li J, Xu HE, Melcher K. Ke J, et al. Sci Adv. 2015 Jul 24;1(6):e1500107. doi: 10.1126/sciadv.1500107. eCollection 2015 Jul. Sci Adv. 2015. PMID: 26601214 Free PMC article.
We confirm the amino-terminal domain of the TPL family of corepressors, which we term TOPLESS domain (TPD), as the EAR motif-binding domain. To understand the structural basis of this interaction, we determined the crystal structures of the TPD of rice (Os) TPR2 in apo (ap …
We confirm the amino-terminal domain of the TPL family of corepressors, which we term TOPLESS domain (TPD), as the EAR motif-binding …
Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis.
Zhi X, Zhou XE, Melcher K, Xu HE. Zhi X, et al. J Steroid Biochem Mol Biol. 2016 Mar;157:27-40. doi: 10.1016/j.jsbmb.2015.06.012. Epub 2015 Jul 6. J Steroid Biochem Mol Biol. 2016. PMID: 26159912 Review.
Here we review the recent literature on orphan nuclear receptor structural analysis and ligand identification, particularly on the orphan nuclear receptors that do not heterodimerize with retinoid X receptors, which we term as non-X orphan receptors. We also propose a spec …
Here we review the recent literature on orphan nuclear receptor structural analysis and ligand identification, particularly on the orphan nu …