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Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Sci Adv. 2015 Jul 24;1(6):e1500107. doi: 10.1126/sciadv.1500107. eCollection 2015 Jul.
Sci Adv. 2015.
PMID: 26601214
Free PMC article.
We confirm the amino-terminal domain of the TPL family of corepressors, which we term TOPLESS domain (TPD), as the EAR motif-binding domain. To understand the structural basis of this interaction, we determined the crystal structures of the TPD of rice (Os) TPR2 in apo (ap …
We confirm the amino-terminal domain of the TPL family of corepressors, which we term TOPLESS domain (TPD), as the EAR motif-binding …
Structures and regulation of non-X orphan nuclear receptors: A retinoid hypothesis.
Zhi X, Zhou XE, Melcher K, Xu HE.
Zhi X, et al.
J Steroid Biochem Mol Biol. 2016 Mar;157:27-40. doi: 10.1016/j.jsbmb.2015.06.012. Epub 2015 Jul 6.
J Steroid Biochem Mol Biol. 2016.
PMID: 26159912
Review.
Here we review the recent literature on orphan nuclear receptor structural analysis and ligand identification, particularly on the orphan nuclear receptors that do not heterodimerize with retinoid X receptors, which we term as non-X orphan receptors. We also propose a spec …
Here we review the recent literature on orphan nuclear receptor structural analysis and ligand identification, particularly on the orphan nu …
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