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Year | Number of Results |
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2004 | 1 |
2010 | 1 |
2011 | 1 |
2024 | 0 |
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SRT1720 improves survival and healthspan of obese mice.
Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18.
Sci Rep. 2011.
PMID: 22355589
Free PMC article.
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1alpha-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibili …
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC- …
SIRT1 is essential for normal cognitive function and synaptic plasticity.
Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD.
Michán S, et al.
J Neurosci. 2010 Jul 21;30(29):9695-707. doi: 10.1523/JNEUROSCI.0027-10.2010.
J Neurosci. 2010.
PMID: 20660252
Free PMC article.
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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.
Cohen HY, et al.
Science. 2004 Jul 16;305(5682):390-2. doi: 10.1126/science.1099196. Epub 2004 Jun 17.
Science. 2004.
PMID: 15205477
Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells....
Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells....
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