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Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals.
Joseph AM, Malamo AG, Silvestre J, Wawrzyniak N, Carey-Love S, Nguyen LM, Dutta D, Xu J, Leeuwenburgh C, Adhihetty PJ. Joseph AM, et al. Exp Gerontol. 2013 Sep;48(9):858-68. doi: 10.1016/j.exger.2013.05.061. Epub 2013 Jun 7. Exp Gerontol. 2013. PMID: 23747682 Free PMC article.
In the present study, we investigated the potential efficacy of using short-term (6 weeks) CR (20%), RSV (50 mg/kg/day), or combined CR+ RSV (20% CR and 50 mg/kg/day RSV), initiated at late-life (27 months) to protect muscle against sarcopenia by altering mitochondrial fun …
In the present study, we investigated the potential efficacy of using short-term (6 weeks) CR (20%), RSV (50 mg/kg/day), or combined …
Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae.
Aris JP, Fishwick LK, Marraffini ML, Seo AY, Leeuwenburgh C, Dunn WA Jr. Aris JP, et al. Subcell Biochem. 2012;57:161-86. doi: 10.1007/978-94-007-2561-4_8. Subcell Biochem. 2012. PMID: 22094422 Free PMC article. Review.
Understanding how non-dividing cells remain viable over long periods of time, which may be decades in humans, is of central importance in understanding mechanisms of aging and longevity. The long-term viability of non-dividing cells, known as chronological longevity, relie …
Understanding how non-dividing cells remain viable over long periods of time, which may be decades in humans, is of central importance in un …
Calorie restriction for optimal cardiovascular aging: the weight of evidence.
Marzetti E, Wohlgemuth SE, Aulisa AG, Bernabei R, Pahor M, Leeuwenburgh C. Marzetti E, et al. Curr Cardiovasc Risk Rep. 2010 Sep 1;4(5):340-346. doi: 10.1007/s12170-010-0114-8. Curr Cardiovasc Risk Rep. 2010. PMID: 26388964 Free PMC article.
Despite the beneficial properties of CR, it is likely that most people will not engage in such a dietary regimen for the long-term. Supplementation with specific compounds mimicking CR may represent a more feasible means to improve health and prolong life. However, evidenc …
Despite the beneficial properties of CR, it is likely that most people will not engage in such a dietary regimen for the long-term. S …
Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats.
Marzetti E, Groban L, Wohlgemuth SE, Lees HA, Lin M, Jobe H, Giovannini S, Leeuwenburgh C, Carter CS. Marzetti E, et al. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R558-67. doi: 10.1152/ajpregu.00620.2007. Epub 2007 Nov 14. Am J Physiol Regul Integr Comp Physiol. 2008. PMID: 18003794 Free article.
On the other hand, resistance training increases muscle mass and strength even when initiated at advanced age. In the present study, we investigated the effects of short-term GH supplementation and exercise training on physical performance and skeletal muscle apoptosis in …
On the other hand, resistance training increases muscle mass and strength even when initiated at advanced age. In the present study, we inve …
Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6.
Kalani R, Judge S, Carter C, Pahor M, Leeuwenburgh C. Kalani R, et al. J Gerontol A Biol Sci Med Sci. 2006 Mar;61(3):211-7. doi: 10.1093/gerona/61.3.211. J Gerontol A Biol Sci Med Sci. 2006. PMID: 16567369
An increase in circulating levels of CRP with age was attenuated with long-term 40% CR; short-term 40% CR in young animals also reduced CRP concentration compared to age-matched controls. ...
An increase in circulating levels of CRP with age was attenuated with long-term 40% CR; short-term 40% CR in young animals als …