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Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis.
Kuppermann N, Ghetti S, Schunk JE, Stoner MJ, Rewers A, McManemy JK, Myers SR, Nigrovic LE, Garro A, Brown KM, Quayle KS, Trainor JL, Tzimenatos L, Bennett JE, DePiero AD, Kwok MY, Perry CS 3rd, Olsen CS, Casper TC, Dean JM, Glaser NS; PECARN DKA FLUID Study Group. Kuppermann N, et al. Among authors: quayle ks. N Engl J Med. 2018 Jun 14;378(24):2275-2287. doi: 10.1056/NEJMoa1716816. N Engl J Med. 2018. PMID: 29897851 Free PMC article. Clinical Trial.
Secondary outcomes included clinically apparent brain injury during treatment for diabetic ketoacidosis, short-term memory during treatment for diabetic ketoacidosis, and memory and IQ 2 to 6 months after recovery from diabetic ketoacidosis. ...No significant differences a …
Secondary outcomes included clinically apparent brain injury during treatment for diabetic ketoacidosis, short-term memory during tre …
Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes.
Myers SR, Glaser NS, Trainor JL, Nigrovic LE, Garro A, Tzimenatos L, Quayle KS, Kwok MY, Rewers A, Stoner MJ, Schunk JE, McManemy JK, Brown KM, DePiero AD, Olsen CS, Casper TC, Ghetti S, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group. Myers SR, et al. Among authors: quayle ks. JAMA Netw Open. 2020 Dec 1;3(12):e2025481. doi: 10.1001/jamanetworkopen.2020.25481. JAMA Netw Open. 2020. PMID: 33275152 Free PMC article.
Children with AKI, compared with those without, had lower scores on tests of short-term memory during DKA (mean [SD] digit span recall: 6.8 [2.4] vs 7.6 [2.2]; P = .02) and lower mean (SD) IQ scores 3 to 6 months after recovery from DKA (100.0 [12.2] vs 103.5 [13.2]; P = . …
Children with AKI, compared with those without, had lower scores on tests of short-term memory during DKA (mean [SD] digit span recal …
Prevalence of Brain Injuries and Recurrence of Seizures in Children With Posttraumatic Seizures.
Badawy MK, Dayan PS, Tunik MG, Nadel FM, Lillis KA, Miskin M, Borgialli DA, Bachman MC, Atabaki SM, Hoyle JD Jr, Holmes JF, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN). Badawy MK, et al. Acad Emerg Med. 2017 May;24(5):595-605. doi: 10.1111/acem.13168. Epub 2017 Apr 10. Acad Emerg Med. 2017. PMID: 28170143 Free article.
OBJECTIVES: Computed tomography (CT) is often used in the emergency department (ED) evaluation of children with posttraumatic seizures (PTS); however, the frequency of traumatic brain injuries (TBIs) and short-term seizure recurrence is lacking. Our main objective was to e …
OBJECTIVES: Computed tomography (CT) is often used in the emergency department (ED) evaluation of children with posttraumatic seizures (PTS) …
Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial.
Glaser NS, Ghetti S, Casper TC, Dean JM, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group. Glaser NS, et al. Pediatr Diabetes. 2013 Sep;14(6):435-46. doi: 10.1111/pedi.12027. Epub 2013 Mar 13. Pediatr Diabetes. 2013. PMID: 23490311 Free PMC article. Clinical Trial.
This 13-center nationwide factorial design study will evaluate the effects of rehydration rate and fluid sodium content on neurological status during DKA treatment, the frequency of clinically overt CE and long-term neurocognitive outcomes following DKA....
This 13-center nationwide factorial design study will evaluate the effects of rehydration rate and fluid sodium content on neurological stat …