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Proteinase-activated receptor-2 blockade inhibits changes seen in a chronic murine asthma model.
Asaduzzaman M, Davidson C, Nahirney D, Fiteih Y, Puttagunta L, Vliagoftis H. Asaduzzaman M, et al. Among authors: puttagunta l. Allergy. 2018 Feb;73(2):416-420. doi: 10.1111/all.13313. Epub 2017 Oct 11. Allergy. 2018. PMID: 28940559
CONCLUSIONS: Our data demonstrate that PAR(2) signaling plays a key role in CE-induced AHR and airway inflammation/remodeling in long term models of allergic airway inflammation. Targeting PAR(2) activation may be a successful therapeutic strategy for allergic asthma....
CONCLUSIONS: Our data demonstrate that PAR(2) signaling plays a key role in CE-induced AHR and airway inflammation/remodeling in long ter …
A case report of living-donor lobar lung transplantation for scleroderma-associated usual interstitial pneumonia: eight years and counting.
Laratta C, Lien D, Puttagunta L, Jackson K, Mullen J, Kapasi A, Weinkauf J. Laratta C, et al. Among authors: puttagunta l. Transplant Proc. 2015 Jan-Feb;47(1):190-3. doi: 10.1016/j.transproceed.2014.10.038. Transplant Proc. 2015. PMID: 25645801
RELEVANCE: This is the second reported case of LDLLT in scleroderma, and the first reporting long-term pulmonary, renal, and esophageal function post-transplantation....
RELEVANCE: This is the second reported case of LDLLT in scleroderma, and the first reporting long-term pulmonary, renal, and esophage …
Long-term outcome of lung transplantation in previous intravenous drug users with talc lung granulomatosis.
Weinkauf JG, Puttagunta L, Nador R, Jackson K, LaBranche K, Kapasi A, Mullen J, Modry DL, Stewart KC, Thakrar M, Doucette K, Lien DC. Weinkauf JG, et al. Among authors: puttagunta l. Transplant Proc. 2013 Jul-Aug;45(6):2375-7. doi: 10.1016/j.transproceed.2012.11.004. Epub 2013 Mar 7. Transplant Proc. 2013. PMID: 23473657
After a careful selection process, 19 patients with talc lung granulomatosis have received lung allografts in our program. Long-term survival for these patients is excellent and our results suggest the previous use of intravenous drugs should not necessarily preclude lung …
After a careful selection process, 19 patients with talc lung granulomatosis have received lung allografts in our program. Long-term …
Mucosal exposure to cockroach extract induces allergic sensitization and allergic airway inflammation.
Arizmendi NG, Abel M, Puttagunta L, Asaduzzaman M, Davidson C, Karimi K, Forsythe P, Vliagoftis H. Arizmendi NG, et al. Among authors: puttagunta l. Allergy Asthma Clin Immunol. 2011 Dec 14;7(1):22. doi: 10.1186/1710-1492-7-22. Allergy Asthma Clin Immunol. 2011. PMID: 22168152 Free PMC article.
RESULTS: Mucosal exposure of Balb/c mice to cockroach extract induced airway eosinophilic inflammation, AHR and cockroach-specific IgG1; however, AHR to methacholine was absent in the long term group. Lung histology showed patchy, multicentric damage with inflammatory infi …
RESULTS: Mucosal exposure of Balb/c mice to cockroach extract induced airway eosinophilic inflammation, AHR and cockroach-specific IgG1; how …
The efficacy of tiotropium as a steroid-sparing agent in severe asthma.
Kapoor AS, Olsen SR, O'Hara C, Puttagunta L, Vethanayagam D. Kapoor AS, et al. Among authors: puttagunta l. Can Respir J. 2009 May-Jun;16(3):99-101. doi: 10.1155/2009/206506. Can Respir J. 2009. PMID: 19557217 Free PMC article.
The role of tiotropium as a potential 'steroid-sparing agent' in severe refractory asthma is discussed, noting that if patients who are on OGS are not monitored for active inflammation, they may overuse the amount of prescribed systemic steroids, which can result in long-term …
The role of tiotropium as a potential 'steroid-sparing agent' in severe refractory asthma is discussed, noting that if patients who are on O …
Do catheter washouts extend patency time in long-term indwelling urethral catheters? A randomized controlled trial of acidic washout solution, normal saline washout, or standard care.
Moore KN, Hunter KF, McGinnis R, Bacsu C, Fader M, Gray M, Getliffe K, Chobanuk J, Puttagunta L, Voaklander DC. Moore KN, et al. Among authors: puttagunta l. J Wound Ostomy Continence Nurs. 2009 Jan-Feb;36(1):82-90. doi: 10.1097/01.WON.0000345181.37656.de. J Wound Ostomy Continence Nurs. 2009. PMID: 19155827 Clinical Trial.
PURPOSE: Blockage of long-term indwelling catheters with mineral deposit is an ongoing management issue, but evidence on optimal management is lacking. ...DESIGN: A multisite randomized controlled trial. SUBJECTS AND SETTING: Adults with long-term indwelling cathete …
PURPOSE: Blockage of long-term indwelling catheters with mineral deposit is an ongoing management issue, but evidence on optimal mana …
Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels.
Michelakis ED, McMurtry MS, Wu XC, Dyck JR, Moudgil R, Hopkins TA, Lopaschuk GD, Puttagunta L, Waite R, Archer SL. Michelakis ED, et al. Among authors: puttagunta l. Circulation. 2002 Jan 15;105(2):244-50. doi: 10.1161/hc0202.101974. Circulation. 2002. PMID: 11790708
CH inhibited I(K), eliminated the acute hypoxia-sensitive I(K), and decreased Kv2.1 channel expression. In the short term, low-dose DCA (1 micromol/L) increased I(K) in CH-PASMCs. In a mammalian expression system, DCA activated Kv2.1 by a tyrosine kinase-dependent mechanis …
CH inhibited I(K), eliminated the acute hypoxia-sensitive I(K), and decreased Kv2.1 channel expression. In the short term, low-dose D …