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Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.
Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Pan Y, et al. Among authors: puigserver p. Nature. 2017 Mar 9;543(7644):252-256. doi: 10.1038/nature21379. Epub 2017 Feb 20. Nature. 2017. PMID: 28219080 Free PMC article.
Tissue-resident memory T (T(RM)) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological pathways that enable the long-term survival of T(RM) cells are obscure. Here we show that mouse CD8(+) T(RM) cells gene …
Tissue-resident memory T (T(RM)) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, t …