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Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer: study protocol of a multicentre, open-label, parallel-arms, randomized controlled study (PelvEx II).
PelvEx Collaborative. PelvEx Collaborative. BJS Open. 2021 May 7;5(3):zrab029. doi: 10.1093/bjsopen/zrab029. BJS Open. 2021. PMID: 34089596 Free PMC article.
The primary endpoint of the study is the R0 resection rate. Secondary endpoints are long-term oncological outcomes, radiological and pathological response, toxicity, postoperative complications, costs, and quality of life. ...
The primary endpoint of the study is the R0 resection rate. Secondary endpoints are long-term oncological outcomes, radiological and …
An international multicentre prospective audit of elective rectal cancer surgery; operative approach versus outcome, including transanal total mesorectal excision (TaTME).
2017 European Society of Coloproctology (ESCP) collaborating group. 2017 European Society of Coloproctology (ESCP) collaborating group. Colorectal Dis. 2018 Sep;20 Suppl 6:33-46. doi: 10.1111/codi.14376. Colorectal Dis. 2018. PMID: 30255642
Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term outcomes of TaTME, open, laparoscopic, and robotic TME internationally. ...
Safety profiles are still emerging and more comparative data is urgently needed. This study aimed to compare indications and short-term …
Comparison of the responses of B1 and B2 kinin receptors to agonist stimulation.
Faussner A, Bathon JM, Proud D. Faussner A, et al. Among authors: proud d. Immunopharmacology. 1999 Dec;45(1-3):13-20. doi: 10.1016/s0162-3109(99)00052-1. Immunopharmacology. 1999. PMID: 10614984 Free article.
The response to stimulation of the B2KR comprises a rapid loss of functional responses, receptor sequestration, and ligand dissociation, and, upon long term stimulation, downregulation. By contrast, ligand stimulation of the B1KR, once this receptor is expressed de novo un …
The response to stimulation of the B2KR comprises a rapid loss of functional responses, receptor sequestration, and ligand dissociation, and …
Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge.
Pipkorn U, Proud D, Lichtenstein LM, Schleimer RP, Peters SP, Adkinson NF Jr, Kagey-Sobotka A, Norman PS, Naclerio RM. Pipkorn U, et al. Among authors: proud d. J Clin Invest. 1987 Oct;80(4):957-61. doi: 10.1172/JCI113188. J Clin Invest. 1987. PMID: 2443539 Free PMC article. Clinical Trial.
As this dose of drug is known to be clinically effective in treating hay fever, the present study confirms the earlier findings of others that short-term systemic glucocorticoid treatment inhibits the late phase but not the immediate phase of antigen challenge. ...
As this dose of drug is known to be clinically effective in treating hay fever, the present study confirms the earlier findings of others th …
Human lung macrophage-derived histamine-releasing activity is due to IgE-dependent factors.
Liu MC, Proud D, Lichtenstein LM, MacGlashan DW Jr, Schleimer RP, Adkinson NF Jr, Kagey-Sobotka A, Schulman ES, Plaut M. Liu MC, et al. Among authors: proud d. J Immunol. 1986 Apr 1;136(7):2588-95. J Immunol. 1986. PMID: 2419444
Human lung macrophages obtained from surgical specimens spontaneously secreted a factor(s) (which we term macrophage factor) during 24-hr culture that induced calcium-dependent histamine release from human basophils and lung mast cells. ...
Human lung macrophages obtained from surgical specimens spontaneously secreted a factor(s) (which we term macrophage factor) during 2 …
Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy.
Creticos PS, Adkinson NF Jr, Kagey-Sobotka A, Proud D, Meier HL, Naclerio RM, Lichtenstein LM, Norman PS. Creticos PS, et al. Among authors: proud d. J Clin Invest. 1985 Dec;76(6):2247-53. doi: 10.1172/JCI112233. J Clin Invest. 1985. PMID: 2416777 Free PMC article.
To determine whether specific immunotherapy alters mediator release in vivo, nasal pollen challenge was used to compare 27 untreated highly sensitive ragweed (RW)-allergic subjects with 12 similarly sensitive patients receiving long-term immunotherapy (3-5 yr) with RW extr …
To determine whether specific immunotherapy alters mediator release in vivo, nasal pollen challenge was used to compare 27 untreated highly …