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Fetal and neonatal iron deficiency but not copper deficiency increases vascular complexity in the developing rat brain.
Bastian TW, Santarriaga S, Nguyen TA, Prohaska JR, Georgieff MK, Anderson GW. Bastian TW, et al. Among authors: prohaska jr. Nutr Neurosci. 2015;18(8):365-75. doi: 10.1179/1476830515Y.0000000037. Epub 2015 Jul 15. Nutr Neurosci. 2015. PMID: 26177275 Free PMC article.
At least initially, this is probably an adaptive response to maintain metabolic substrate homeostasis in the developing iron-deficient brain. However, this may also contribute to long-term neurodevelopmental deficits....
At least initially, this is probably an adaptive response to maintain metabolic substrate homeostasis in the developing iron-deficient brain …
Maternofetal and neonatal copper requirements revealed by enterocyte-specific deletion of the Menkes disease protein.
Wang Y, Zhu S, Hodgkinson V, Prohaska JR, Weisman GA, Gitlin JD, Petris MJ. Wang Y, et al. Among authors: prohaska jr. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1236-44. doi: 10.1152/ajpgi.00339.2012. Epub 2012 Oct 11. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 23064757 Free PMC article.
Although mice lacking Atp7a protein within intestinal enterocytes appeared normal at birth, they exhibited profound growth impairment and neurological deterioration as a consequence of copper deficiency, resulting in excessive mortality prior to weaning. ...Enterocyte-spec …
Although mice lacking Atp7a protein within intestinal enterocytes appeared normal at birth, they exhibited profound growth impairment …
Abnormal motor function persists following recovery from perinatal copper deficiency in rats.
Penland JG, Prohaska JR. Penland JG, et al. Among authors: prohaska jr. J Nutr. 2004 Aug;134(8):1984-8. doi: 10.1093/jn/134.8.1984. J Nutr. 2004. PMID: 15284387 Free article.
These results suggest that permanent impairment to motor function can persist after long-term recovery from perinatal copper deficiency....
These results suggest that permanent impairment to motor function can persist after long-term recovery from perinatal copper deficien …
Auditory startle response is diminished in rats after recovery from perinatal copper deficiency.
Prohaska JR, Hoffman RG. Prohaska JR, et al. J Nutr. 1996 Mar;126(3):618-27. doi: 10.1093/jn/126.3.618. J Nutr. 1996. PMID: 8598546
In a separate study, postweaning male rats deprived of dietary copper for 5 wk exhibited clear signs of copper deficiency but normal acoustic startle responses and foot splay. Long-term neurochemical and behavioral abnormalities persist in rats after perinatal copper defic …
In a separate study, postweaning male rats deprived of dietary copper for 5 wk exhibited clear signs of copper deficiency but normal acousti …
Development of the stable isotope tracer approach for studies of copper turnover in the rat and mouse.
Ting BT, Lee CC, Janghorbani M, Prohaska JR. Ting BT, et al. Among authors: prohaska jr. J Nutr Biochem. 1990 May;1(5):249-55. doi: 10.1016/0955-2863(90)90074-u. J Nutr Biochem. 1990. PMID: 15539212
The stable isotope tracer approach was explored for long-term investigations of copper turnover in the adult rat and mouse, with inductively coupled plasma mass spectrometry for isotope measurements. ...
The stable isotope tracer approach was explored for long-term investigations of copper turnover in the adult rat and mouse, with indu …