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Education, employment, and income among people living with cystic fibrosis across three decades - A matched cohort study using Danish health registries.
Jensen CB, Jensen KJ, Pressler T, Katzenstein TL, Skov M, Qvist T, Olsen MF, Jeppesen M, Jensen-Fangel S, Olesen HV, Reuter SB, Pedersen HKR, Wang JN, Michalopoulos S, McGarry L, Wöhling H, Petersen J, Jimenez-Solem E; TransformCF study group. Jensen CB, et al. Among authors: pressler t. J Cyst Fibros. 2024 Mar 14:S1569-1993(24)00039-0. doi: 10.1016/j.jcf.2024.03.009. Online ahead of print. J Cyst Fibros. 2024. PMID: 38485602
BACKGROUND: Past and ongoing advancements in cystic fibrosis (CF) care warrant long-term analysis of the societal impact of the condition. This study aims to evaluate changes in key socioeconomic factors across three decades among people living with CF (pwCF), compared wit …
BACKGROUND: Past and ongoing advancements in cystic fibrosis (CF) care warrant long-term analysis of the societal impact of the condi …
Antimicrobial Strategies for Cystic Fibrosis.
Møller R, Pressler T, Qvist T. Møller R, et al. Among authors: pressler t. Semin Respir Crit Care Med. 2023 Apr;44(2):297-306. doi: 10.1055/s-0042-1758733. Epub 2022 Dec 19. Semin Respir Crit Care Med. 2023. PMID: 36535665
While many different strategies may be applied, rigorous microbiological surveillance, intensive eradication therapy, and long-term maintenance therapy based on inhaled antibiotics may be considered the main strategy for infection control in individuals with CF. ...
While many different strategies may be applied, rigorous microbiological surveillance, intensive eradication therapy, and long-term m …
Long-term amikacin liposome inhalation suspension in cystic fibrosis patients with chronic P. aeruginosa infection.
Bilton D, Fajac I, Pressler T, Clancy JP, Sands D, Minic P, Cipolli M, Galeva I, Solé A, Quittner AL, Jumadilova Z, Ciesielska M, Konstan MW; CLEAR-110 Study Group. Bilton D, et al. Among authors: pressler t. J Cyst Fibros. 2021 Nov;20(6):1010-1017. doi: 10.1016/j.jcf.2021.05.013. Epub 2021 Jun 16. J Cyst Fibros. 2021. PMID: 34144923 Free PMC article. Clinical Trial.
The CLEAR-110 extension study (ClinicalTrials.gov: NCT01316276; EudraCT: 2011-000443-24) assessed long-term safety, tolerability, and efficacy of ALIS in eligible patients who completed CLEAR-108. ...Mean change from baseline in sputum density of P. aeruginosa at day 672 w …
The CLEAR-110 extension study (ClinicalTrials.gov: NCT01316276; EudraCT: 2011-000443-24) assessed long-term safety, tolerability, and …
Withdrawal of dornase alfa increases ventilation inhomogeneity in children with cystic fibrosis.
Voldby C, Green K, Philipsen L, Sandvik RM, Skov M, Buchvald F, Pressler T, Nielsen KG. Voldby C, et al. Among authors: pressler t. J Cyst Fibros. 2021 Nov;20(6):949-956. doi: 10.1016/j.jcf.2021.02.004. Epub 2021 Feb 19. J Cyst Fibros. 2021. PMID: 33619014 Free article. Clinical Trial.
Hence, adherence to dornase alfa optimally needs to be addressed when using LCI and spirometric parameters as endpoints, even in short-term clinical trials....
Hence, adherence to dornase alfa optimally needs to be addressed when using LCI and spirometric parameters as endpoints, even in short-te …
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability, and efficacy of tezacaftor-ivacaftor in participants aged 12 years or older with cystic fibrosis who were homozygous or heterozygous for t …
Here, we present results of study 661-110 (EXTEND), a 96-week open-label extension study that assessed long-term safety, tolerability …
Bacterial persisters in long-term infection: Emergence and fitness in a complex host environment.
Bartell JA, Cameron DR, Mojsoska B, Haagensen JAJ, Pressler T, Sommer LM, Lewis K, Molin S, Johansen HK. Bartell JA, et al. Among authors: pressler t. PLoS Pathog. 2020 Dec 14;16(12):e1009112. doi: 10.1371/journal.ppat.1009112. eCollection 2020 Dec. PLoS Pathog. 2020. PMID: 33315938 Free PMC article.
In sum, the Hip phenotype appears to substantially contribute to long-term establishment of a lineage in the CF lung environment. Our results argue against the existence of a single dominant molecular mechanism underlying bacterial antibiotic persistence. ...
In sum, the Hip phenotype appears to substantially contribute to long-term establishment of a lineage in the CF lung environment. Our …
Coach to cope: feasibility of a life coaching program for young adults with cystic fibrosis.
Knudsen KB, Pressler T, Mortensen LH, Jarden M, Boisen KA, Skov M, Quittner AL, Katzenstein TL. Knudsen KB, et al. Among authors: pressler t. Patient Prefer Adherence. 2017 Sep 21;11:1613-1623. doi: 10.2147/PPA.S141267. eCollection 2017. Patient Prefer Adherence. 2017. PMID: 29033550 Free PMC article.
However, several studies have demonstrated that many young adults with CF report mental health problems and poor adherence to their prescribed treatments, challenging their long-term physical health. Treatment guidelines recommend interventions to improve adherence and sel …
However, several studies have demonstrated that many young adults with CF report mental health problems and poor adherence to their prescrib …
The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection -- a pilot study.
Skov M, Pressler T, Lykkesfeldt J, Poulsen HE, Jensen PØ, Johansen HK, Qvist T, Kræmer D, Høiby N, Ciofu O. Skov M, et al. Among authors: pressler t. J Cyst Fibros. 2015 Mar;14(2):211-8. doi: 10.1016/j.jcf.2014.09.015. Epub 2014 Oct 23. J Cyst Fibros. 2015. PMID: 25458464 Free article. Clinical Trial.
Achromobacter species in cystic fibrosis: cross-infection caused by indirect patient-to-patient contact.
Hansen CR, Pressler T, Ridderberg W, Johansen HK, Skov M. Hansen CR, et al. Among authors: pressler t. J Cyst Fibros. 2013 Dec;12(6):609-15. doi: 10.1016/j.jcf.2013.05.004. Epub 2013 Jun 12. J Cyst Fibros. 2013. PMID: 23769270 Free article.
Both cases became positive for A. ruhlandii in airway secretions and were colonized with A. ruhlandii in their sinuses. Aggressive, long-term antibiotic treatment led to clinical stability. One of the cases developed chronic A. ruhlandii infection. ...
Both cases became positive for A. ruhlandii in airway secretions and were colonized with A. ruhlandii in their sinuses. Aggressive, long- …
The use of propensity scores and observational data to estimate randomized controlled trial generalizability bias.
Pressler TR, Kaizar EE. Pressler TR, et al. Stat Med. 2013 Sep 10;32(20):3552-68. doi: 10.1002/sim.5802. Epub 2013 Apr 1. Stat Med. 2013. PMID: 23553373 Free PMC article.
We propose to use observational data to estimate the bias due to enrollment restrictions, which we term generalizability bias. In this paper, we introduce a class of estimators for the generalizability bias and use simulation to study its properties in the presence of non- …
We propose to use observational data to estimate the bias due to enrollment restrictions, which we term generalizability bias. In thi …
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