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Maternal recognition of pregnancy in the pig: A servomechanism involving sex steroids, cytokines and prostaglandins.
Geisert RD, Bazer FW, Lucas CG, Pfeiffer CA, Meyer AE, Sullivan R, Johns DN, Sponchiado M, Prather RS. Geisert RD, et al. Among authors: prather rs. Anim Reprod Sci. 2024 May;264:107452. doi: 10.1016/j.anireprosci.2024.107452. Epub 2024 Mar 12. Anim Reprod Sci. 2024. PMID: 38522133 Review.
Maternal recognition of pregnancy (MRP) is a term utilized in mammals to describe pathways in which the conceptus alters the endometrial environment to prevent regression of corpora lutea to ensure continued production of progesterone (P4) required for establishment and ma …
Maternal recognition of pregnancy (MRP) is a term utilized in mammals to describe pathways in which the conceptus alters the endometr …
Profiling development of abdominal organs in the pig.
Gabriel GC, Devine WA, Redel BK, Whitworth KM, Samuel M, Spate LD, Cecil RF, Prather RS, Wu YL, Wells KD, Lo CW. Gabriel GC, et al. Among authors: prather rs. Sci Rep. 2022 Sep 28;12(1):16245. doi: 10.1038/s41598-022-19960-5. Sci Rep. 2022. PMID: 36171243 Free PMC article.
Normal pigs at different gestational ages from day 20 (D20) to term were examined and the configuration of the abdominal organs was studied using 3D histological reconstructions with episcopic confocal microscopy, magnetic resonance imaging (MRI) and necropsy. ...
Normal pigs at different gestational ages from day 20 (D20) to term were examined and the configuration of the abdominal organs was s …
Effects of RAD51-stimulatory compound 1 (RS-1) and its vehicle, DMSO, on pig embryo culture.
Lucas CG, Redel BK, Chen PR, Spate LD, Prather RS, Wells KD. Lucas CG, et al. Among authors: prather rs. Reprod Toxicol. 2021 Oct;105:44-52. doi: 10.1016/j.reprotox.2021.08.002. Epub 2021 Aug 15. Reprod Toxicol. 2021. PMID: 34407461 Free PMC article.
Transient exposure to 7.5 muM of RS-1 did not adversely affect early embryo development and was compatible with subsequent development to term. Additionally, low concentrations of its vehicle, DMSO, did not show any toxicity to in vitro produced embryos. ...
Transient exposure to 7.5 muM of RS-1 did not adversely affect early embryo development and was compatible with subsequent development to …
Cardiovascular Development and Congenital Heart Disease Modeling in the Pig.
Gabriel GC, Devine W, Redel BK, Whitworth KM, Samuel M, Spate LD, Cecil RF, Prather RS, Wu Y, Wells KD, Lo CW. Gabriel GC, et al. Among authors: prather rs. J Am Heart Assoc. 2021 Jul 20;10(14):e021631. doi: 10.1161/JAHA.121.021631. Epub 2021 Jul 3. J Am Heart Assoc. 2021. PMID: 34219463 Free PMC article.
Methods and Results Pig conceptuses and fetuses were collected spanning 7 stages (day 20 to birth at day 115), with at least 3 embryos analyzed per stage. A combination of magnetic resonance imaging and 3-dimensional histological reconstructions with episcopic confocal mic …
Methods and Results Pig conceptuses and fetuses were collected spanning 7 stages (day 20 to birth at day 115), with at least 3 embryo …
Gene editing to investigate the role of conceptus factors in the establishment of pregnancy in the pig.
Geisert RD, Meyer AE, Pfeiffer CA, Johns DN, Lee K, Wells KD, Spencer TE, Prather RS. Geisert RD, et al. Among authors: prather rs. Reproduction. 2021 Apr;161(4):R79-R88. doi: 10.1530/REP-20-0604. Reproduction. 2021. PMID: 33560267 Review.
In addition to the retention of the fetus and secretion of nutrients to support growth and development to term, it is essential that viviparous species modify or inhibit the maternal immune system from recognizing the semi-allogeneic fetus. ...
In addition to the retention of the fetus and secretion of nutrients to support growth and development to term, it is essential that …
Zygote injection of RNA encoding Cre recombinase results in efficient removal of LoxP flanked neomycin cassettes in pigs.
Whitworth KM, Cecil R, Benne JA, Redel BK, Spate LD, Samuel MS, Prather RS, Wells KD. Whitworth KM, et al. Among authors: prather rs. Transgenic Res. 2018 Apr;27(2):167-178. doi: 10.1007/s11248-018-0064-3. Epub 2018 Mar 7. Transgenic Res. 2018. PMID: 29516259

This method successfully removed the neomycin cassette in 81.9% of injected in vitro derived embryos; which was significantly higher than the control (P < 0.0001). Embryo transfer resulted in the birth of one live piglet with a Cre deleted neomycin cassette. The new met

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This method successfully removed the neomycin cassette in 81.9% of injected in vitro derived embryos; which was significantly higher than th …
Effects of combined treatment of MG132 and scriptaid on early and term development of porcine somatic cell nuclear transfer embryos.
Mao J, Tessanne K, Whitworth KM, Spate LD, Walters EM, Samuel MS, Murphy CN, Tracy L, Zhao J, Prather RS. Mao J, et al. Among authors: prather rs. Cell Reprogram. 2012 Oct;14(5):385-9. doi: 10.1089/cell.2012.0018. Epub 2012 Aug 23. Cell Reprogram. 2012. PMID: 22917492 Free PMC article.
There was no difference in the oocyte-donor cell fusion rate, number of embryos transferred, pregnancy rate at days 28, 60, and at term, pigs delivered per embryo transfer, litter size, body weight at birth, nor cloning efficiency between the Scriptaid-alone control …
There was no difference in the oocyte-donor cell fusion rate, number of embryos transferred, pregnancy rate at days 28, 60, and at term …
Birth of piglets from in vitro-produced, zona-intact porcine embryos vitrified in a closed system.
Men H, Zhao C, Si W, Murphy CN, Spate L, Liu Y, Walters EM, Samuel MS, Prather RS, Critser JK. Men H, et al. Among authors: prather rs. Theriogenology. 2011 Jul 15;76(2):280-9. doi: 10.1016/j.theriogenology.2011.02.004. Epub 2011 Mar 31. Theriogenology. 2011. PMID: 21458047 Free PMC article.
When delipidated embryos were vitrified at the blastocyst stage, there was no difference in survival between embryos vitrified using OPS and 0.25 mL straws. Some embryos vitrified by each method developed to term. These experiments demonstrated that porcine embryos can be …
When delipidated embryos were vitrified at the blastocyst stage, there was no difference in survival between embryos vitrified using OPS and …
Altered gene expression in cloned piglets.
Tian XC, Park J, Bruno R, French R, Jiang L, Prather RS. Tian XC, et al. Among authors: prather rs. Reprod Fertil Dev. 2009;21(1):60-6. doi: 10.1071/rd08214. Reprod Fertil Dev. 2009. PMID: 19152746 Review.
Studies on cloned pigs are scant compared with those in mice and cattle. Expression profiles of cloned pig embryos on full-term cloned pigs are even more limited owing to the limited availability of DNA microarray technology in the pig. We have conducted expression profile …
Studies on cloned pigs are scant compared with those in mice and cattle. Expression profiles of cloned pig embryos on full-term clone …
Production of endothelial nitric oxide synthase (eNOS) over-expressing piglets.
Hao YH, Yong HY, Murphy CN, Wax D, Samuel M, Rieke A, Lai L, Liu Z, Durtschi DC, Welbern VR, Price EM, McAllister RM, Turk JR, Laughlin MH, Prather RS, Rucker EB. Hao YH, et al. Among authors: prather rs. Transgenic Res. 2006 Dec;15(6):739-50. doi: 10.1007/s11248-006-9020-8. Epub 2006 Nov 2. Transgenic Res. 2006. PMID: 17080303
Thus both activation conditions and culture systems are compatible with development to term. These pigs will serve as the founders for a colony of miniature pigs that will help to elucidate the function of eNOS in regulating muscle metabolism and the cardiorespiratory syst …
Thus both activation conditions and culture systems are compatible with development to term. These pigs will serve as the founders fo …
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