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Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity.
Bryce DK, Ware CM, Woodhouse JD, Ciaccio PJ, Ellis JM, Hegde LG, Kuruvilla S, Maddess ML, Markgraf CG, Otte KM, Poulet FM, Timmins LM, Kennedy ME, Fell MJ. Bryce DK, et al. Among authors: poulet fm. J Pharmacol Exp Ther. 2021 Apr;377(1):11-19. doi: 10.1124/jpet.120.000217. Epub 2021 Jan 28. J Pharmacol Exp Ther. 2021. PMID: 33509901
SIGNIFICANCE STATEMENT: We have defined a mouse model by which the on-target lung effects of leucine-rich kinase 2 (LRRK2) kinase inhibition can be monitored, whereas previous in vivo testing relied solely on nonhuman primates. Data serve to derisk long-term treatment with …
SIGNIFICANCE STATEMENT: We have defined a mouse model by which the on-target lung effects of leucine-rich kinase 2 (LRRK2) kinase inhibition …
Clinical and microbiological features of Clostridium difficile infections in France: the ICD-RAISIN 2009 national survey.
Eckert C, Coignard B, Hebert M, Tarnaud C, Tessier C, Lemire A, Burghoffer B, Noel D, Barbut F; ICD-Raisin Working Group. Eckert C, et al. Med Mal Infect. 2013 Feb;43(2):67-74. doi: 10.1016/j.medmal.2013.01.004. Epub 2013 Mar 14. Med Mal Infect. 2013. PMID: 23498135
RESULTS: One hundred and five HCF with acute care wards and 95 with rehabilitation/long-term care (RLTC) wards participated in the 6-month epidemiological study. ...
RESULTS: One hundred and five HCF with acute care wards and 95 with rehabilitation/long-term care (RLTC) wards participated in the 6- …
Phyllosilicates on Mars and implications for early martian climate.
Poulet F, Bibring JP, Mustard JF, Gendrin A, Mangold N, Langevin Y, Arvidson RE, Gondet B, Gomez C, Berthé M, Erard S, Forni O, Manaud N, Poulleau G, Soufflot A, Combes M, Drossart P, Encrenaz T, Fouchet T, Melchiorri R, Bellucci G, Altieri F, Formisano V, Fonti S, Capaccioni F, Cerroni P, Coradini A, Korablev O, Kottsov V, Ignatiev N, Titov D, Zasova L, Pinet P, Schmitt B, Sotin C, Hauber E, Hoffmann H, Jaumann R, Keller U, Forget F; Omega Team. Poulet F, et al. Nature. 2005 Dec 1;438(7068):623-7. doi: 10.1038/nature04274. Nature. 2005. PMID: 16319882
These minerals are mainly associated with Noachian outcrops, which is consistent with an early active hydrological system, sustaining the long-term contact of igneous minerals with liquid water. We infer that the two main families of hydrated alteration products detected-p …
These minerals are mainly associated with Noachian outcrops, which is consistent with an early active hydrological system, sustaining the lo …