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Cross-species analysis of SHH medulloblastoma models reveals significant inhibitory effects of trametinib on tumor progression.
Borlase S, DeCarlo A, Coudière-Morrison L, Liang L, Porter CJ, Ramaswamy V, Werbowetski-Ogilvie TE. Borlase S, et al. Among authors: porter cj. Cell Death Discov. 2023 Sep 19;9(1):347. doi: 10.1038/s41420-023-01646-0. Cell Death Discov. 2023. PMID: 37726268 Free PMC article.
However, IL6/JAK STAT3 and TNFalpha/NFkappaB signaling gene sets are specifically upregulated following trametinib treatment in vivo indicative of compensatory molecular changes following long-term MEK inhibition. Our study reveals a novel role for trametinib in effectivel …
However, IL6/JAK STAT3 and TNFalpha/NFkappaB signaling gene sets are specifically upregulated following trametinib treatment in vivo indicat …
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.
Mai QN, Shenoy P, Quach T, Retamal JS, Gondin AB, Yeatman HR, Aurelio L, Conner JW, Poole DP, Canals M, Nowell CJ, Graham B, Davis TP, Briddon SJ, Hill SJ, Porter CJH, Bunnett NW, Halls ML, Veldhuis NA. Mai QN, et al. Among authors: porter cjh. J Biol Chem. 2021 Jan-Jun;296:100345. doi: 10.1016/j.jbc.2021.100345. Epub 2021 Jan 28. J Biol Chem. 2021. PMID: 33515548 Free PMC article.
However, the extent to which the Chol-anchor influences long-term location and activity is poorly understood. Herein, we used fluorescent correlation spectroscopy and targeted biosensors to characterize Span-Chol over time. ...
However, the extent to which the Chol-anchor influences long-term location and activity is poorly understood. Herein, we used fluores …
Engineering Biocoatings To Prolong Drug Release from Supraparticles.
Ma Y, Cortez-Jugo C, Li J, Lin Z, Richardson RT, Han Y, Zhou J, Björnmalm M, Feeney OM, Zhong QZ, Porter CJH, Wise AK, Caruso F. Ma Y, et al. Among authors: porter cjh. Biomacromolecules. 2019 Sep 9;20(9):3425-3434. doi: 10.1021/acs.biomac.9b00710. Epub 2019 Aug 14. Biomacromolecules. 2019. PMID: 31411865 Free article.
Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of interest for long-term, sustained drug release in biomedical applications. However, a key challenge to achieving temporal control of drug release fro …
Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of interest for lon …
Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery.
Ma Y, Björnmalm M, Wise AK, Cortez-Jugo C, Revalor E, Ju Y, Feeney OM, Richardson RT, Hanssen E, Shepherd RK, Porter CJH, Caruso F. Ma Y, et al. Among authors: porter cjh. ACS Appl Mater Interfaces. 2018 Sep 19;10(37):31019-31031. doi: 10.1021/acsami.8b10415. Epub 2018 Sep 7. ACS Appl Mater Interfaces. 2018. PMID: 30192499 Free article.
Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeutics in biomedical applications. ...Drug loading kinetics and loading capacity for six different types of Si-SPs, using a model protein drug (fl …
Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeutics …
Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets.
Pan Y, Choy KHC, Marriott PJ, Chai SY, Scanlon MJ, Porter CJH, Short JL, Nicolazzo JA. Pan Y, et al. Among authors: porter cjh. J Neurochem. 2018 Jan;144(1):81-92. doi: 10.1111/jnc.14249. J Neurochem. 2018. PMID: 29105065 Free article.
This study reports a 42.1 12.6% decrease in the BBB transport of (14) C-DHA in 8-month-old AD transgenic mice (APPswe,PSEN1E9) relative to wild-type mice, associated with a 34.5 6.7% reduction in FABP5 expression in isolated brain capillaries of AD mice. Furthermore, short-ter …
This study reports a 42.1 12.6% decrease in the BBB transport of (14) C-DHA in 8-month-old AD transgenic mice (APPswe,PSEN1E9) relative to w …
Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function.
Pan Y, Short JL, Choy KH, Zeng AX, Marriott PJ, Owada Y, Scanlon MJ, Porter CJ, Nicolazzo JA. Pan Y, et al. Among authors: porter cj. J Neurosci. 2016 Nov 16;36(46):11755-11767. doi: 10.1523/JNEUROSCI.1583-16.2016. J Neurosci. 2016. PMID: 27852782 Free PMC article.
Cognitive function was assessed in male and female FABP5(+/+) and FABP5(-/-) mice using a battery of memory paradigms. FABP5(-/-) mice exhibited impaired working memory and short-term memory, and these cognitive deficits were associated with a 14.7 5.7% reduction in endoge …
Cognitive function was assessed in male and female FABP5(+/+) and FABP5(-/-) mice using a battery of memory paradigms. FABP5(-/-) mice exhib …
Vitamin D status in renal transplant recipients.
Stavroulopoulos A, Cassidy MJ, Porter CJ, Hosking DJ, Roe SD. Stavroulopoulos A, et al. Among authors: porter cj. Am J Transplant. 2007 Nov;7(11):2546-52. doi: 10.1111/j.1600-6143.2007.01978.x. Epub 2007 Oct 1. Am J Transplant. 2007. PMID: 17908281 Free article.
We measured serum 25-hydroxyvitamin D levels (25-OHD) in 244 renal transplant recipients, divided into two groups, 104 recently transplanted (less than 1 year) and 140 long-term. Vitamin D status was defined according to NKF/KDOQI guidelines. ...An inverse correlation was …
We measured serum 25-hydroxyvitamin D levels (25-OHD) in 244 renal transplant recipients, divided into two groups, 104 recently transplanted …
Feline calicivirus.
Radford AD, Coyne KP, Dawson S, Porter CJ, Gaskell RM. Radford AD, et al. Among authors: porter cj. Vet Res. 2007 Mar-Apr;38(2):319-35. doi: 10.1051/vetres:2006056. Epub 2007 Feb 13. Vet Res. 2007. PMID: 17296159 Free article. Review.
In such cats, virus evolution is believed to help the virus to evade the host immune response. Such long-term carriers may only represent a minority of the feline population but are likely to be crucial to the epidemiology of the virus. ...
In such cats, virus evolution is believed to help the virus to evade the host immune response. Such long-term carriers may only repre …
Evolutionary mechanisms of persistence and diversification of a calicivirus within endemically infected natural host populations.
Coyne KP, Gaskell RM, Dawson S, Porter CJ, Radford AD. Coyne KP, et al. Among authors: porter cj. J Virol. 2007 Feb;81(4):1961-71. doi: 10.1128/JVI.01981-06. Epub 2006 Dec 6. J Virol. 2007. PMID: 17151126 Free PMC article.
By sequencing immunodominant and variable regions of the capsid gene, we identified the relative contribution of the different evolutionary processes employed by the virus to ensure its long-term survival in the host population. Such strategies included progressive evoluti …
By sequencing immunodominant and variable regions of the capsid gene, we identified the relative contribution of the different evolutionary …
Long-term analysis of feline calicivirus prevalence and viral shedding patterns in naturally infected colonies of domestic cats.
Coyne KP, Dawson S, Radford AD, Cripps PJ, Porter CJ, McCracken CM, Gaskell RM. Coyne KP, et al. Among authors: porter cj. Vet Microbiol. 2006 Nov 26;118(1-2):12-25. doi: 10.1016/j.vetmic.2006.06.026. Epub 2006 Sep 5. Vet Microbiol. 2006. PMID: 16911860 Free PMC article.
In order to assess how FCV circulates in such groups and to assess the contribution that each individual animal makes to the epidemiology of the disease, we have carried out the first detailed analysis of long-term shedding patterns of FCV in individual cats within natural …
In order to assess how FCV circulates in such groups and to assess the contribution that each individual animal makes to the epidemiology of …
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