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In vivo effects of the association of the psychoactive phenotiazine thioridazine on antitumor activity and hind limb paralysis induced by the native polypeptide crotamine.
Porta LC, Campeiro JD, Papa GB, Oliveira EB, Godinho RO, Rodrigues T, Hayashi MAF. Porta LC, et al. Toxicon. 2020 Oct 15;185:64-71. doi: 10.1016/j.toxicon.2020.06.017. Epub 2020 Jul 2. Toxicon. 2020. PMID: 32621838 Free article.
In spite of the clear efficacy of these both compounds as anticancer agents in long-term in vivo treatment of animal model bearing implanted xenograph melanoma tumor, the expected mutual potentiation of the antitumor effects was not observed here. ...
In spite of the clear efficacy of these both compounds as anticancer agents in long-term in vivo treatment of animal model bearing im …
Long term safety of targeted internalization of cell penetrating peptide crotamine into renal proximal tubular epithelial cells in vivo.
Campeiro JD, Dam W, Monte GG, Porta LC, Oliveira LCG, Nering MB, Viana GM, Carapeto FC, Oliveira EB, van den Born J, Hayashi MAF. Campeiro JD, et al. Among authors: porta lc. Sci Rep. 2019 Mar 1;9(1):3312. doi: 10.1038/s41598-019-39842-7. Sci Rep. 2019. PMID: 30824773 Free PMC article.
Herein we demonstrate for the first time, the overall safety of acute or long-term treatment with daily ip administrated crotamine for kidneys functions. ...Taken together, our present data show the safety of in vivo long-term treatment with crotamine, and its prefe …
Herein we demonstrate for the first time, the overall safety of acute or long-term treatment with daily ip administrated crotamine fo …
A Population-Based Cohort Study on the Drug-Specific Effect of Statins on Sepsis Outcome.
Lee CC, Lee MG, Hsu TC, Porta L, Chang SS, Yo CH, Tsai KC, Lee M. Lee CC, et al. Among authors: porta l. Chest. 2018 Apr;153(4):805-815. doi: 10.1016/j.chest.2017.09.024. Epub 2017 Sep 27. Chest. 2018. PMID: 28962887
BACKGROUND: Whether statin treatment, proved by recent experimental studies to have an antimicrobial activity, exerts a drug- or a class-specific effect in sepsis remains unknown. METHODS: Short-term mortality in patients with sepsis was analyzed using data from the Nation …
BACKGROUND: Whether statin treatment, proved by recent experimental studies to have an antimicrobial activity, exerts a drug- or a class-spe …
[Quality of life, depression and cognitive functions 6. Cognitive functions].
Rete Infermieri GISSI-HF. Rete Infermieri GISSI-HF. Assist Inferm Ric. 2009 Jan-Mar;28(1):34-8. Assist Inferm Ric. 2009. PMID: 19462699 Italian.
AIM: To describe the prevalence of CI and to assess its prognostic value on the increased risk of hospitalizations and death over the medium term (3 years). RESULTS: MMSE was administered to 620/745 heart failure patients >70 years. ...
AIM: To describe the prevalence of CI and to assess its prognostic value on the increased risk of hospitalizations and death over the medium …