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Page 1
Heparanase and Type 1 Diabetes.
Simeonovic CJ, Popp SK, Brown DJ, Li FJ, Lafferty ARA, Freeman C, Parish CR. Simeonovic CJ, et al. Among authors: popp sk. Adv Exp Med Biol. 2020;1221:607-630. doi: 10.1007/978-3-030-34521-1_24. Adv Exp Med Biol. 2020. PMID: 32274728 Review.
We have identified dual activity heparanase inhibitors/HS replacers as a novel class of therapeutic for preventing T1D progression and potentially for mitigating secondary vascular disease that develops with long-term T1D....
We have identified dual activity heparanase inhibitors/HS replacers as a novel class of therapeutic for preventing T1D progression and poten …
Alignment with neighbours enables escape from dead ends in flocking models.
Joshi V, Popp S, Werfel J, McCreery HF. Joshi V, et al. Among authors: popp s. J R Soc Interface. 2022 Aug;19(193):20220356. doi: 10.1098/rsif.2022.0356. Epub 2022 Aug 17. J R Soc Interface. 2022. PMID: 35975561 Free PMC article.
We find that groups of such agents heading for a goal can spontaneously escape dead ends without wall-following or other specialized behaviours, in what we term 'flocking escapes'. The mechanism arises when agents align with one another while heading away from the goal, fo …
We find that groups of such agents heading for a goal can spontaneously escape dead ends without wall-following or other specialized behavio …
Serotonin Deficiency Increases Context-Dependent Fear Learning Through Modulation of Hippocampal Activity.
Waider J, Popp S, Mlinar B, Montalbano A, Bonfiglio F, Aboagye B, Thuy E, Kern R, Thiel C, Araragi N, Svirin E, Schmitt-Böhrer AG, Corradetti R, Lowry CA, Lesch KP. Waider J, et al. Among authors: popp s. Front Neurosci. 2019 Apr 24;13:245. doi: 10.3389/fnins.2019.00245. eCollection 2019. Front Neurosci. 2019. PMID: 31068767 Free PMC article.
The behavioral responses were associated with increased c-Fos expression in the dHip and resistance to foot shock-induced impairment of hippocampal long-term potentiation (LTP). In conclusion, increased context-dependent fear memory resulting from brain 5-HT deficiency inv …
The behavioral responses were associated with increased c-Fos expression in the dHip and resistance to foot shock-induced impairment of hipp …
Increased fear learning, spatial learning as well as neophobia in Rgs2-/- mice.
Raab A, Popp S, Lesch KP, Lohse MJ, Fischer M, Deckert J, Hommers L. Raab A, et al. Among authors: popp s. Genes Brain Behav. 2018 Apr;17(4):e12420. doi: 10.1111/gbb.12420. Epub 2017 Sep 22. Genes Brain Behav. 2018. PMID: 28846187 Free article.
In this study, Rgs2(-/-) mice showed increased fear learning, male mice displayed increased contextual and cued fear learning, while females showed selectively enhanced cued fear learning. Male Rgs2(-/-) mice displayed increased long-term-contextual fear memory, but increa …
In this study, Rgs2(-/-) mice showed increased fear learning, male mice displayed increased contextual and cued fear learning, while females …
Influence of pre-analytical conditions on the measurement of components of the GH/IGF axis in rats.
Bielohuby M, Popp S, Bidlingmaier M. Bielohuby M, et al. Among authors: popp s. Growth Horm IGF Res. 2013 Oct;23(5):141-8. doi: 10.1016/j.ghir.2013.05.001. Epub 2013 Jun 15. Growth Horm IGF Res. 2013. PMID: 23773927
We therefore now systematically investigated if and how commonly used sample processing and pre-treatment protocols affect measured hormone concentrations of the GH/IGF system in rats. Furthermore, we explored if short term fasting, age and circadian rhythmicity have an im …
We therefore now systematically investigated if and how commonly used sample processing and pre-treatment protocols affect measured hormone …
Identification of Cholecystokinin by Genome-Wide Profiling as Potential Mediator of Serotonin-Dependent Behavioral Effects of Maternal Separation in the Amygdala.
Weidner MT, Lardenoije R, Eijssen L, Mogavero F, De Groodt LPMT, Popp S, Palme R, Förstner KU, Strekalova T, Steinbusch HWM, Schmitt-Böhrer AG, Glennon JC, Waider J, van den Hove DLA, Lesch KP. Weidner MT, et al. Among authors: popp s. Front Neurosci. 2019 May 10;13:460. doi: 10.3389/fnins.2019.00460. eCollection 2019. Front Neurosci. 2019. PMID: 31133792 Free PMC article.
Converging evidence suggests a role of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme of 5-HT synthesis in the brain, in modulating long-term, neurobiological effects of early-life adversity. Here, we aimed at further el …
Converging evidence suggests a role of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme o …
Prenatal tetrahydrocannabinol (THC) alters cognitive function and amphetamine response from weaning to adulthood in the rat.
Silva L, Zhao N, Popp S, Dow-Edwards D. Silva L, et al. Among authors: popp s. Neurotoxicol Teratol. 2012 Jan-Feb;34(1):63-71. doi: 10.1016/j.ntt.2011.10.006. Epub 2011 Nov 6. Neurotoxicol Teratol. 2012. PMID: 22080840 Free PMC article.
Offspring were exposed to three tests: a passive avoidance test at postnatal day (PND) 22, an active place avoidance test at PND 45, and an attention task at PND 60, which assessed learning and long-term memory, spatial working memory and prediction, and attention, respect …
Offspring were exposed to three tests: a passive avoidance test at postnatal day (PND) 22, an active place avoidance test at PND 45, and an …
Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature.
Boukamp P, Popp S, Bleuel K, Tomakidi E, Bürkle A, Fusenig NE. Boukamp P, et al. Among authors: popp s. Oncogene. 1999 Oct 7;18(41):5638-45. doi: 10.1038/sj.onc.1202934. Oncogene. 1999. PMID: 10523843
Cyclin D1, a candidate gene of that region was overexpressed in all tumor-derived cells but cyclinD1/cdk4/cdk6 kinase activity was not increased. Thus, these data demonstrate that long-term thermal stress is a potential carcinogenic factor in this relevant skin cancer mode …
Cyclin D1, a candidate gene of that region was overexpressed in all tumor-derived cells but cyclinD1/cdk4/cdk6 kinase activity was not incre …
Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT.
Boukamp P, Popp S, Altmeyer S, Hülsen A, Fasching C, Cremer T, Fusenig NE. Boukamp P, et al. Among authors: popp s. Genes Chromosomes Cancer. 1997 Aug;19(4):201-14. doi: 10.1002/(sici)1098-2264(199708)19:4<201::aid-gcc1>3.0.co;2-0. Genes Chromosomes Cancer. 1997. PMID: 9258654
To examine the significance of this functional relationship, we investigated the long-term development of the spontaneously immortalized human skin keratinocyte line HaCaT, carrying UV-specific mutations in both alleles of the TP53 tumor suppressor gene. ...Thus, our data …
To examine the significance of this functional relationship, we investigated the long-term development of the spontaneously immortali …
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