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Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study.
McClung MR, O'Donoghue ML, Papapoulos SE, Bone H, Langdahl B, Saag KG, Reid IR, Kiel DP, Cavallari I, Bonaca MP, Wiviott SD, de Villiers T, Ling X, Lippuner K, Nakamura T, Reginster JY, Rodriguez-Portales JA, Roux C, Zanchetta J, Zerbini CAF, Park JG, Im K, Cange A, Grip LT, Heyden N, DaSilva C, Cohn D, Massaad R, Scott BB, Verbruggen N, Gurner D, Miller DL, Blair ML, Polis AB, Stoch SA, Santora A, Lombardi A, Leung AT, Kaufman KD, Sabatine MS; LOFT Investigators. McClung MR, et al. Lancet Diabetes Endocrinol. 2019 Dec;7(12):899-911. doi: 10.1016/S2213-8587(19)30346-8. Epub 2019 Oct 31. Lancet Diabetes Endocrinol. 2019. PMID: 31676222 Clinical Trial.
We aimed to investigate the efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis. METHODS: The Long-term Odanacatib Fracture Trial (LOFT) was a multicentre, randomised, double-blind, placebo-controlled, event-driven study at 3 …
We aimed to investigate the efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis. METHODS: Th …
Skeletal status assessment by quantitative ultrasound and bone densitometry in children with different renal conditions.
Adamczyk P, Szczepanska M, Pluskiewicz W. Adamczyk P, et al. Among authors: pluskiewicz w. Osteoporos Int. 2018 Dec;29(12):2667-2675. doi: 10.1007/s00198-018-4659-6. Epub 2018 Aug 20. Osteoporos Int. 2018. PMID: 30128765 Free PMC article.
DXA scanning, performed at lumbar spine, is potentially more appropriate to reveal disturbances secondary to long-term GC therapy, whereas TB-DXA is highly effective in the identification of skeletal disturbances related to decreased kidney function. ...
DXA scanning, performed at lumbar spine, is potentially more appropriate to reveal disturbances secondary to long-term GC therapy, wh …
Bone mineral density and body composition after laparoscopic sleeve gastrectomy in men: A short-term longitudinal study.
Adamczyk P, Bužga M, Holéczy P, Švagera Z, Šmajstrla V, Zonča P, Pluskiewicz W. Adamczyk P, et al. Among authors: pluskiewicz w. Int J Surg. 2015 Nov;23(Pt A):101-7. doi: 10.1016/j.ijsu.2015.09.048. Epub 2015 Sep 25. Int J Surg. 2015. PMID: 26408948 Free article.
INTRODUCTION: Longitudinal changes in bone and body composition occurring in obese men after laparoscopic sleeve gastrectomy (LSG) has been evaluated. METHODS: In short-term longitudinal study, 25 obese men in mean baseline age 44.8 10.9 years and mean body mass index (BMI …
INTRODUCTION: Longitudinal changes in bone and body composition occurring in obese men after laparoscopic sleeve gastrectomy (LSG) has been …
Assessment of skeletal status by quantitative ultrasound at the hand phalanges in children with bronchial asthma--a pilot study.
Adamczyk P, Pluskiewicz W, Halaba Z, Nowakowski M, Madaj A, Drozdzowska B. Adamczyk P, et al. Among authors: pluskiewicz w. Ultrasound Med Biol. 2011 Nov;37(11):1802-7. doi: 10.1016/j.ultrasmedbio.2011.07.013. Epub 2011 Sep 15. Ultrasound Med Biol. 2011. PMID: 21924820
In conclusion, the skeletal status in asthmatic children, assessed by quantitative ultrasound, shows no difference in comparison with healthy children. Nonetheless, special caution is necessary in case of long-term corticosteroid therapy, in which a slightly negative influ …
In conclusion, the skeletal status in asthmatic children, assessed by quantitative ultrasound, shows no difference in comparison with health …
Official Positions for FRAX® clinical regarding falls and frailty: can falls and frailty be used in FRAX®? From Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®.
Masud T, Binkley N, Boonen S, Hannan MT; FRAX(®) Position Development Conference Members. Masud T, et al. J Clin Densitom. 2011 Jul-Sep;14(3):194-204. doi: 10.1016/j.jocd.2011.05.010. J Clin Densitom. 2011. PMID: 21810525
However, quantitative adjustment of the FRAX estimated risk based on falls history is not currently possible. In the long term, incorporation of falls as a risk factor in the FRAX model would be ideal....
However, quantitative adjustment of the FRAX estimated risk based on falls history is not currently possible. In the long term, incor …
Bone status in adolescents with type 1 diabetes.
Chobot AP, Haffke A, Polanska J, Halaba ZP, Deja G, Jarosz-Chobot P, Pluskiewicz W. Chobot AP, et al. Among authors: pluskiewicz w. Diabetologia. 2010 Aug;53(8):1754-60. doi: 10.1007/s00125-010-1782-0. Epub 2010 May 9. Diabetologia. 2010. PMID: 20454951
CONCLUSIONS: Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent on long-term metabolic control....
CONCLUSIONS: Bone status of adolescents with type 1 diabetes mellitus assessed with QUS differs from that of healthy peers and is dependent …
The efficacy of alendronate in wheelchair-bound patients: a 1-year prospective study.
Pluskiewicz W, Adamczyk P, Sawaryn P, Boroń A, Misiołek M, Sosada K, Drozdzowska B. Pluskiewicz W, et al. J Pediatr Orthop B. 2009 May;18(3):157-62. doi: 10.1097/BPB.0b013e32832b0790. J Pediatr Orthop B. 2009. PMID: 19384106
No patient treated revealed the increase in three bone densitometric variables and only one showed a decrease in ICTP exceeding 40% of baseline value. Concluding, in wheelchair-bound participants short-term alendronate therapy does not reduce bone resorption and does not i …
No patient treated revealed the increase in three bone densitometric variables and only one showed a decrease in ICTP exceeding 40% of basel …
Quantitative ultrasound and densitometric measurements and laboratory variables in patients on long-term acenocoumarol therapy.
Pluskiewicz W, Zurek J. Pluskiewicz W, et al. Int J Clin Pract. 2007 Aug;61(8):1328-32. doi: 10.1111/j.1742-1241.2006.00906.x. Epub 2007 May 30. Int J Clin Pract. 2007. PMID: 17537183
In conclusion, despite of the lack of changes in skeletal status, male subjects on long-term acenocumarol therapy may be at high risk for fracture due to disturbances in bone turnover....
In conclusion, despite of the lack of changes in skeletal status, male subjects on long-term acenocumarol therapy may be at high risk …
Phalangeal quantitative ultrasound measurements in former pre-term children aged 9-11 years.
Halaba ZP, Bursa J, Kaplon UK, Pluskiewicz W, Marciniak S, Drzewiecka U. Halaba ZP, et al. Among authors: pluskiewicz w. Br J Radiol. 2007 Jun;80(954):401-5. doi: 10.1259/bjr/55460700. Epub 2006 Oct 26. Br J Radiol. 2007. PMID: 17068013
The objective of this study was to compare phalangeal ultrasound values in 38 former pre-term children, aged 9-11 years, with 50 age-matched term controls. ...There were no significant differences in values of Ad-SoS, weight and height between patients and controls …
The objective of this study was to compare phalangeal ultrasound values in 38 former pre-term children, aged 9-11 years, with 50 age- …
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