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Engineered red blood cells carrying PCSK9 inhibitors persistently lower LDL and prevent obesity.
Deshycka R, Sudaryo V, Huang NJ, Xie Y, Smeding LY, Choi MK, Ploegh HL, Lodish HF, Pishesha N. Deshycka R, et al. Among authors: ploegh hl. PLoS One. 2021 Nov 3;16(11):e0259353. doi: 10.1371/journal.pone.0259353. eCollection 2021. PLoS One. 2021. PMID: 34731223 Free PMC article.
Antibody and RNAi-based PCSK9 inhibitor treatments lower cholesterol and prevent cardiovascular incidents in patients, but their high-cost hampers market penetration. We sought to develop a safe, long-term and one-time solution to treat hyperlipidemia. We created a cDNA en …
Antibody and RNAi-based PCSK9 inhibitor treatments lower cholesterol and prevent cardiovascular incidents in patients, but their high-cost h …
Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity.
Fang T, Van Elssen CHMJ, Duarte JN, Guzman JS, Chahal JS, Ling J, Ploegh HL. Fang T, et al. Among authors: ploegh hl. Chem Sci. 2017 Aug 1;8(8):5591-5597. doi: 10.1039/c7sc00446j. Epub 2017 May 26. Chem Sci. 2017. PMID: 28970938 Free PMC article.
A single boost 12 months after primary immunization triggered a recall response of the same quality, suggesting that long-term alphaMUC1(Tn) memory had been achieved....
A single boost 12 months after primary immunization triggered a recall response of the same quality, suggesting that long-term alphaM …
A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.
Walters BJ, Hallengren JJ, Theile CS, Ploegh HL, Wilson SM, Dobrunz LE. Walters BJ, et al. Among authors: ploegh hl. J Physiol. 2014 Feb 15;592(4):571-86. doi: 10.1113/jphysiol.2013.266015. Epub 2013 Nov 11. J Physiol. 2014. PMID: 24218545 Free PMC article.
USP14 is a proteasome-bound deubiquitinating enzyme that recycles ubiquitin and regulates synaptic short-term synaptic plasticity. We previously reported that loss of USP14 in ax(J) mice causes a deficit in paired pulse facilitation (PPF) at hippocampal synapses. ...
USP14 is a proteasome-bound deubiquitinating enzyme that recycles ubiquitin and regulates synaptic short-term synaptic plasticity. We …
Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.
Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL. Kirak O, et al. Among authors: ploegh hl. J Vis Exp. 2010 Sep 30;(43):2168. doi: 10.3791/2168. J Vis Exp. 2010. PMID: 20972401 Free PMC article.
However, such TCRs are usually isolated from the relevant T cells after long-term culture often following repeated antigen stimulation, which unavoidably selects for T cells with high affinity. ...
However, such TCRs are usually isolated from the relevant T cells after long-term culture often following repeated antigen stimulatio …
Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT.
Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL. Kirak O, et al. Among authors: ploegh hl. Science. 2010 Apr 9;328(5975):243-8. doi: 10.1126/science.1178590. Science. 2010. PMID: 20378817 Free PMC article.
Such TCRs are usually isolated from the relevant T cells after long-term culture, often after repeated antigen stimulation, which unavoidably skews the T cell population used. ...
Such TCRs are usually isolated from the relevant T cells after long-term culture, often after repeated antigen stimulation, which una …
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
Wilson DC, Grotenbreg GM, Liu K, Zhao Y, Frickel EM, Gubbels MJ, Ploegh HL, Yap GS. Wilson DC, et al. Among authors: ploegh hl. PLoS Pathog. 2010 Mar 19;6(3):e1000815. doi: 10.1371/journal.ppat.1000815. PLoS Pathog. 2010. PMID: 20333242 Free PMC article.
Thus, despite the beneficial role of IL-12 in promoting effector differentiation, excessive exposure to IL-12 during CTL priming may limit the development of long-term protective immunity through the decreased fitness of central memory CTL responses....
Thus, despite the beneficial role of IL-12 in promoting effector differentiation, excessive exposure to IL-12 during CTL priming may limit t …
Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines.
Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Koch KS, et al. Among authors: ploegh hl. Immunology. 2006 Sep;119(1):98-115. doi: 10.1111/j.1365-2567.2006.02412.x. Epub 2006 Jul 10. Immunology. 2006. PMID: 16836618 Free PMC article.
Embryonic mouse STO (S, SIM; T, 6-thioguanine resistant; O, ouabain resistant) and 3(8)21-enhanced green fluorescent protein (EGFP) cell lines exhibit long-term survival and hepatic progenitor cell behaviour after xenogeneic engraftment in non-immunosuppressed inbred rats, …
Embryonic mouse STO (S, SIM; T, 6-thioguanine resistant; O, ouabain resistant) and 3(8)21-enhanced green fluorescent protein (EGFP) cell lin …
Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond.
Lilley BN, Ploegh HL. Lilley BN, et al. Among authors: ploegh hl. Immunol Rev. 2005 Oct;207:126-44. doi: 10.1111/j.0105-2896.2005.00318.x. Immunol Rev. 2005. PMID: 16181332 Review.
Viruses that establish long-term infections in their hosts have evolved a number of methods to interfere with the activities of the innate and adaptive immune systems. ...
Viruses that establish long-term infections in their hosts have evolved a number of methods to interfere with the activities of the i …