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Phosphodiesterase inhibition facilitates cognitive restoration in rodent models of age-related memory decline.
Devan BD, Pistell PJ, Duffy KB, Kelley-Bell B, Spangler EL, Ingram DK. Devan BD, et al. Among authors: pistell pj. NeuroRehabilitation. 2014;34(1):101-11. doi: 10.3233/NRE-131022. NeuroRehabilitation. 2014. PMID: 24284467
Despite these limitations, PDE5 inhibition may produce beneficial effects via several mechanisms that target predisposing risk factors leading to increased incidence of memory impairment in aged individuals and influence memory consolidation mechanisms that preserve long-term …
Despite these limitations, PDE5 inhibition may produce beneficial effects via several mechanisms that target predisposing risk factors leadi …
Roux-en-Y gastric bypass surgery changes food reward in rats.
Shin AC, Zheng H, Pistell PJ, Berthoud HR. Shin AC, et al. Among authors: pistell pj. Int J Obes (Lond). 2011 May;35(5):642-51. doi: 10.1038/ijo.2010.174. Epub 2010 Aug 31. Int J Obes (Lond). 2011. PMID: 20805826 Free PMC article.
The changes in hedonic evaluation also resulted in lower long-term preference/acceptance of high-fat diets compared with sham-operated (obese) rats. ...
The changes in hedonic evaluation also resulted in lower long-term preference/acceptance of high-fat diets compared with sham-operate …
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling.
Morrison CD, Pistell PJ, Ingram DK, Johnson WD, Liu Y, Fernandez-Kim SO, White CL, Purpera MN, Uranga RM, Bruce-Keller AJ, Keller JN. Morrison CD, et al. Among authors: pistell pj. J Neurochem. 2010 Sep;114(6):1581-9. doi: 10.1111/j.1471-4159.2010.06865.x. Epub 2010 Jul 27. J Neurochem. 2010. PMID: 20557430 Free PMC article.
Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. ...
Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. ...
Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels.
Stranahan AM, Lee K, Pistell PJ, Nelson CM, Readal N, Miller MG, Spangler EL, Ingram DK, Mattson MP. Stranahan AM, et al. Among authors: pistell pj. Neurobiol Learn Mem. 2008 Sep;90(2):479-83. doi: 10.1016/j.nlm.2008.05.005. Epub 2008 Jun 24. Neurobiol Learn Mem. 2008. PMID: 18579418 Free PMC article.
Diabetes and normal aging are both characterized by increases in levels of glucocorticoids. Because long-term exposure to elevated glucocorticoids can be detrimental to hippocampal function, we evaluated the performance of young diabetic rats in the 14-unit T-maze, a task …
Diabetes and normal aging are both characterized by increases in levels of glucocorticoids. Because long-term exposure to elevated gl …
Apoptotic and behavioral sequelae of mild brain trauma in mice.
Tweedie D, Milman A, Holloway HW, Li Y, Harvey BK, Shen H, Pistell PJ, Lahiri DK, Hoffer BJ, Wang Y, Pick CG, Greig NH. Tweedie D, et al. Among authors: pistell pj. J Neurosci Res. 2007 Mar;85(4):805-15. doi: 10.1002/jnr.21160. J Neurosci Res. 2007. PMID: 17243171
Although it does not result in clear morphological brain defects, it is associated with long-term cognitive, emotional, and behavioral problems. Herein, we characterized the biochemical and behavioral changes associated with experimental mTBI in mice that may act as either …
Although it does not result in clear morphological brain defects, it is associated with long-term cognitive, emotional, and behaviora …