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Gfi1 Loss Protects against Two Models of Induced Diabetes.
Napolitano T, Avolio F, Silvano S, Forcisi S, Pfeifer A, Vieira A, Navarro-Sanz S, Friano ME, Ayachi C, Garrido-Utrilla A, Atlija J, Hadzic B, Becam J, Sousa-De-Veiga A, Plaisant MD, Balaji S, Pisani DF, Mondin M, Schmitt-Kopplin P, Amri EZ, Collombat P. Napolitano T, et al. Among authors: pisani df. Cells. 2021 Oct 20;10(11):2805. doi: 10.3390/cells10112805. Cells. 2021. PMID: 34831029 Free PMC article.
To assess the role of Gfi1 in the pathogenesis of diabetes, we challenged Gfi1-deficient mice with two models of induced hyperglycemia: long-term high-fat/high-sugar feeding and streptozotocin injections. Results: Interestingly, mutant mice did not show any obvious deleter …
To assess the role of Gfi1 in the pathogenesis of diabetes, we challenged Gfi1-deficient mice with two models of induced hyperglycemia: long …
Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice.
Raad G, Serra F, Martin L, Derieppe MA, Gilleron J, Costa VL, Pisani DF, Amri EZ, Trabucchi M, Grandjean V. Raad G, et al. Among authors: pisani df. Elife. 2021 Mar 30;10:e61736. doi: 10.7554/eLife.61736. Elife. 2021. PMID: 33783350 Free PMC article.
Mechanistically, sperm RNA microinjection experiments into zygotes suggest that sperm RNAs are sufficient for establishment but not for long-term maintenance of epigenetic inheritance of metabolic pathologies. ...
Mechanistically, sperm RNA microinjection experiments into zygotes suggest that sperm RNAs are sufficient for establishment but not for long …
The adiponectin receptor agonist AdipoRon normalizes glucose metabolism and prevents obesity but not growth retardation induced by glucocorticoids in young mice.
Nicolas S, Rochet N, Gautier N, Chabry J, Pisani DF. Nicolas S, et al. Among authors: pisani df. Metabolism. 2020 Feb;103:154027. doi: 10.1016/j.metabol.2019.154027. Epub 2019 Nov 26. Metabolism. 2020. PMID: 31778708
We have previously demonstrated the efficacy of a treatment with a non-peptidic agonist of adiponectin receptors, AdipoRon, to reverse behaviour disorders and fat mass gain induced by long-term GC treatment. In this work, we have established a relevant model of GC-induced …
We have previously demonstrated the efficacy of a treatment with a non-peptidic agonist of adiponectin receptors, AdipoRon, to reverse behav …
Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome.
Melis N, Rubera I, Cougnon M, Giraud S, Mograbi B, Belaid A, Pisani DF, Huber SM, Lacas-Gervais S, Fragaki K, Blondeau N, Vigne P, Frelin C, Hauet T, Duranton C, Tauc M. Melis N, et al. Among authors: pisani df. J Am Soc Nephrol. 2017 Mar;28(3):811-822. doi: 10.1681/ASN.2016010012. Epub 2016 Sep 9. J Am Soc Nephrol. 2017. PMID: 27612998 Free PMC article.
Notably, eIF5A may be involved in regulating the lifespan of Drosophila during long-term hypoxia. Therefore, we investigated the possibility of a link between eIF5A hypusination and cellular resistance to hypoxia/anoxia. ...
Notably, eIF5A may be involved in regulating the lifespan of Drosophila during long-term hypoxia. Therefore, we investigated the poss …
Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers.
Loft A, Forss I, Siersbæk MS, Schmidt SF, Larsen AS, Madsen JG, Pisani DF, Nielsen R, Aagaard MM, Mathison A, Neville MJ, Urrutia R, Karpe F, Amri EZ, Mandrup S. Loft A, et al. Among authors: pisani df. Genes Dev. 2015 Jan 1;29(1):7-22. doi: 10.1101/gad.250829.114. Epub 2014 Dec 12. Genes Dev. 2015. PMID: 25504365 Free PMC article.
Long-term exposure to peroxisome proliferator-activated receptor gamma (PPARgamma) agonists such as rosiglitazone induces browning of rodent and human adipocytes; however, the transcriptional mechanisms governing this phenotypic switch in adipocytes are largely unknown. .. …
Long-term exposure to peroxisome proliferator-activated receptor gamma (PPARgamma) agonists such as rosiglitazone induces browning of …