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Neutral effect of SGLT2 inhibitors on lipoprotein metabolism: From clinical evidence to molecular mechanisms.
Osto E, Bonacina F, Pirillo A, Norata GD. Osto E, et al. Among authors: pirillo a. Pharmacol Res. 2023 Feb;188:106667. doi: 10.1016/j.phrs.2023.106667. Epub 2023 Jan 16. Pharmacol Res. 2023. PMID: 36657502 Free article.
This, however, may also fuel hepatic cholesterol synthesis, thus inhibiting atherogenic lipoprotein uptake from the liver. Long-term studies collecting detailed information on lipid-lowering therapies at baseline and during the trials with SGLT2i, as well as regularly moni …
This, however, may also fuel hepatic cholesterol synthesis, thus inhibiting atherogenic lipoprotein uptake from the liver. Long-term …
Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors.
Baragetti A, Bonacina F, Da Dalt L, Moregola A, Zampoleri V, Pellegatta F, Grigore L, Pirillo A, Spina R, Cefalù AB, Averna M, Norata GD, Catapano AL. Baragetti A, et al. Among authors: pirillo a. Eur J Prev Cardiol. 2022 May 5;29(5):721-729. doi: 10.1093/eurjpc/zwaa115. Eur J Prev Cardiol. 2022. PMID: 33624064
Shorter LTL was confirmed in leucocytes of LDLR-KO vs. wild-type mice and associated with lower abundance of long-term haematopoietic stem and progenitor cells (LT-HSPCs) in the bone marrow. ...
Shorter LTL was confirmed in leucocytes of LDLR-KO vs. wild-type mice and associated with lower abundance of long-term haematopoietic …
Dietary linoleic acid and human health: Focus on cardiovascular and cardiometabolic effects.
Marangoni F, Agostoni C, Borghi C, Catapano AL, Cena H, Ghiselli A, La Vecchia C, Lercker G, Manzato E, Pirillo A, Riccardi G, Risé P, Visioli F, Poli A. Marangoni F, et al. Among authors: pirillo a. Atherosclerosis. 2020 Jan;292:90-98. doi: 10.1016/j.atherosclerosis.2019.11.018. Epub 2019 Nov 15. Atherosclerosis. 2020. PMID: 31785494 Review.
Overall, data from clinical studies and meta-analyses suggest an association between high dietary intakes or tissue levels of n-6 PUFA, and specifically LA, and the improvement of cardiovascular risk (mainly of the plasma lipid profile), as well as long-term glycaemic cont …
Overall, data from clinical studies and meta-analyses suggest an association between high dietary intakes or tissue levels of n-6 PUFA, and …
Cholesterol metabolism, pancreatic β-cell function and diabetes.
Perego C, Da Dalt L, Pirillo A, Galli A, Catapano AL, Norata GD. Perego C, et al. Among authors: pirillo a. Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2149-2156. doi: 10.1016/j.bbadis.2019.04.012. Epub 2019 Apr 26. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31029825 Free article. Review.
Available data exclude that this could be the case for other hypocholesterolemic approaches, but long-term studies are warranted to explore this critical aspect....
Available data exclude that this could be the case for other hypocholesterolemic approaches, but long-term studies are warranted to e …
Cardiovascular events with PCSK9 inhibitors: an updated meta-analysis of randomised controlled trials.
Casula M, Olmastroni E, Boccalari MT, Tragni E, Pirillo A, Catapano AL. Casula M, et al. Among authors: pirillo a. Pharmacol Res. 2019 May;143:143-150. doi: 10.1016/j.phrs.2019.03.021. Epub 2019 Mar 26. Pharmacol Res. 2019. PMID: 30926528
Despite that, the pooled analysis failed to show a significant cardiovascular mortality benefit with anti-PCSK9 mAb treatment, suggesting that specific longer-term studies are warranted to address this issue. We suggest that the observed delay between the rapid effect on p …
Despite that, the pooled analysis failed to show a significant cardiovascular mortality benefit with anti-PCSK9 mAb treatment, suggesting th …