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Page 1
Myocardial ischemia and reperfusion leads to transient CD8 immune deficiency and accelerated immunosenescence in CMV-seropositive patients.
Hoffmann J, Shmeleva EV, Boag SE, Fiser K, Bagnall A, Murali S, Dimmick I, Pircher H, Martin-Ruiz C, Egred M, Keavney B, von Zglinicki T, Das R, Todryk S, Spyridopoulos I. Hoffmann J, et al. Among authors: pircher h. Circ Res. 2015 Jan 2;116(1):87-98. doi: 10.1161/CIRCRESAHA.116.304393. Epub 2014 Nov 10. Circ Res. 2015. PMID: 25385851 Free PMC article.
Using high-throughput 13-parameter flow cytometry and human leukocyte antigen class I cytomegalovirus-specific dextramers, we confirmed an acute and persistent depletion of terminally differentiated TEMRA and cytomegalovirus-specific CD8(+) cells in cytomegalovirus-seropositive p …
Using high-throughput 13-parameter flow cytometry and human leukocyte antigen class I cytomegalovirus-specific dextramers, we confirmed an a …
Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells.
Legat A, Speiser DE, Pircher H, Zehn D, Fuertes Marraco SA. Legat A, et al. Among authors: pircher h. Front Immunol. 2013 Dec 19;4:455. doi: 10.3389/fimmu.2013.00455. eCollection 2013. Front Immunol. 2013. PMID: 24391639 Free PMC article.
We show that many iRs are expressed upon activation, and with progressive differentiation to effector cells, even in absence of long-term ("chronic") antigenic stimulation. In particular, we evaluated the direct relationship between iR expression and functionality in CD8 T …
We show that many iRs are expressed upon activation, and with progressive differentiation to effector cells, even in absence of long-term …
Purification and characterization of native human insulin-like growth factor binding protein-6.
Taferner A, Micutkova L, Hermann M, Jansen-Dürr P, Pircher H. Taferner A, et al. Among authors: pircher h. J Cell Commun Signal. 2011 Dec;5(4):277-89. doi: 10.1007/s12079-011-0126-2. Epub 2011 Mar 23. J Cell Commun Signal. 2011. PMID: 21484185 Free PMC article.
Cellular uptake studies were performed to further characterize the purified protein, showing no short-term uptake of IGFBP-6, in contrast to IGFBP-3....
Cellular uptake studies were performed to further characterize the purified protein, showing no short-term uptake of IGFBP-6, in cont …
Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility.
Massoner P, Colleselli D, Matscheski A, Pircher H, Geley S, Jansen Dürr P, Klocker H. Massoner P, et al. Among authors: pircher h. Endocr Relat Cancer. 2009 Sep;16(3):795-808. doi: 10.1677/ERC-08-0175. Epub 2009 Jun 9. Endocr Relat Cancer. 2009. PMID: 19509068
As expected, IGFBP-3 inhibited IGF-stimulated cell proliferation by blocking IGF-mediated proliferation signals, but we observed an IGF-independent inhibitory effect of IGFBP-3 on prostate cancer cell proliferation in long-term cultures. We further investigated the influen …
As expected, IGFBP-3 inhibited IGF-stimulated cell proliferation by blocking IGF-mediated proliferation signals, but we observed an IGF-inde …
Characterization of a subset of antigen-specific human central memory CD4+ T lymphocytes producing effector cytokines.
Stubbe M, Vanderheyde N, Pircher H, Goldman M, Marchant A. Stubbe M, et al. Among authors: pircher h. Eur J Immunol. 2008 Jan;38(1):273-82. doi: 10.1002/eji.200737611. Eur J Immunol. 2008. PMID: 18081039 Free article.
CCR7(+ )central memory (T(CM)) CD4(+) T cells play a central role in long-term immunological memory. Recent reports indicate that a proportion of CD4(+) T(CM) is able to produce effector cytokines. ...KLRG1(+) T(CM) expressed high levels of CD127, suggesting that they can …
CCR7(+ )central memory (T(CM)) CD4(+) T cells play a central role in long-term immunological memory. Recent reports indicate that a p …
In Vivo Persistence of Codominant Human CD8+ T Cell Clonotypes Is Not Limited by Replicative Senescence or Functional Alteration.
Derré L, Bruyninx M, Baumgaertner P, Devevre E, Corthesy P, Touvrey C, Mahnke YD, Pircher H, Voelter V, Romero P, Speiser DE, Rufer N. Derré L, et al. Among authors: pircher h. J Immunol. 2007 Aug 15;179(4):2368-79. doi: 10.4049/jimmunol.179.4.2368. J Immunol. 2007. PMID: 17675498 Free article. Clinical Trial.
Interestingly, the final prevalence of the different T cell clonotypes in circulation was anticipated in a metastatic lymph node withdrawn 2 years earlier, suggesting in vivo clonotype selection driven by metastases. Together, these data provide novel insight in long term …
Interestingly, the final prevalence of the different T cell clonotypes in circulation was anticipated in a metastatic lymph node withdrawn 2 …
Cutting edge: CCR7+ and CCR7- memory T cells do not differ in immediate effector cell function.
Unsoeld H, Krautwald S, Voehringer D, Kunzendorf U, Pircher H. Unsoeld H, et al. Among authors: pircher h. J Immunol. 2002 Jul 15;169(2):638-41. doi: 10.4049/jimmunol.169.2.638. J Immunol. 2002. PMID: 12097363
Nonetheless, both T cell populations isolated from spleen and liver produced identical amounts of IFN-gamma after short-term Ag stimulation. Furthermore, CCR7(+) and CCR7(-) CD8 TCR-tg cells from LCMV-infected mice exhibited similar lytic activity against LCMV peptide-coat …
Nonetheless, both T cell populations isolated from spleen and liver produced identical amounts of IFN-gamma after short-term Ag stimu …
Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection.
Ehl S, Aichele P, Ramseier H, Barchet W, Hombach J, Pircher H, Hengartner H, Zinkernagel RM. Ehl S, et al. Among authors: pircher h. Nat Med. 1998 Sep;4(9):1015-9. doi: 10.1038/2001. Nat Med. 1998. PMID: 9734393
These findings show that antigen-specific tolerization can induce graft acceptance even when begun after transplantation and that long-term graft survival depends on persistence of the tolerizing antigen....
These findings show that antigen-specific tolerization can induce graft acceptance even when begun after transplantation and that long-te …
Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts.
Zimmerman C, Brduscha-Riem K, Blaser C, Zinkernagel RM, Pircher H. Zimmerman C, et al. Among authors: pircher h. J Exp Med. 1996 Apr 1;183(4):1367-75. doi: 10.1084/jem.183.4.1367. J Exp Med. 1996. PMID: 8666895 Free PMC article.
The cellular basis of T cell memory is a controversial issue and progress has been hampered by the inability to induce and to trace long-term memory T cells specific for a defined antigen in vivo. By using the murine model of lymphocytic choriomeningitis virus (LCMV) infec …
The cellular basis of T cell memory is a controversial issue and progress has been hampered by the inability to induce and to trace long- …
A monoclonal antibody against altered LFA-1 induces proliferation and lymphokine release of cloned T cells.
Pircher H, Groscurth P, Baumhütter S, Aguet M, Zinkernagel RM, Hengartner H. Pircher H, et al. Eur J Immunol. 1986 Feb;16(2):172-81. doi: 10.1002/eji.1830160212. Eur J Immunol. 1986. PMID: 2420606
A murine monoclonal antibody (I-17, IgM) has the following functional effects on murine long-term T cell clones: inhibition of cell-mediated lysis, induction of proliferation, release of lymphokines and change of the cell morphology. The determinant detected by I-17 is exp …
A murine monoclonal antibody (I-17, IgM) has the following functional effects on murine long-term T cell clones: inhibition of cell-m …
12 results