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Fatty acid amide hydrolase inhibition alleviates anxiety-like symptoms in a rat model used to study post-traumatic stress disorder.
Fotio Y, Mabou Tagne A, Jung KM, Piomelli D. Fotio Y, et al. Among authors: piomelli d. Psychopharmacology (Berl). 2023 Apr 5. doi: 10.1007/s00213-023-06358-y. Online ahead of print. Psychopharmacology (Berl). 2023. PMID: 37017699
In the present study, we investigated the effects of two novel brain-permeable FAAH inhibitors - the compounds ARN14633 and ARN14280 - in a rat model of predator stress-induced long-term anxiety used to study PTSD. METHODS: We exposed male Sprague-Dawley rats to 2,5-dihydr …
In the present study, we investigated the effects of two novel brain-permeable FAAH inhibitors - the compounds ARN14633 and ARN14280 - in a …
Diet-Induced Obesity Disrupts Histamine-Dependent Oleoylethanolamide Signaling in the Mouse Liver.
Lin L, Mabou Tagne A, Squire EN, Lee HL, Fotio Y, Ramirez J, Zheng M, Torrens A, Ahmed F, Ramos R, Plikus MV, Piomelli D. Lin L, et al. Among authors: piomelli d. Pharmacology. 2022;107(7-8):423-432. doi: 10.1159/000524753. Epub 2022 Jun 10. Pharmacology. 2022. PMID: 35691287 Free article.
We measured histamine, OEA, and other fatty-acid ethanolamides by liquid-chromatography/mass spectrometry, gene transcription by RT-PCR, protein expression by ELISA, neutral lipid accumulation in the liver using Red Oil O and BODIPY staining, and collagen levels using picrosirius …
We measured histamine, OEA, and other fatty-acid ethanolamides by liquid-chromatography/mass spectrometry, gene transcription by RT-PCR, pro …
Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents.
Le AA, Quintanilla J, Amani M, Piomelli D, Lynch G, Gall CM. Le AA, et al. Among authors: piomelli d. Neurobiol Dis. 2022 Jan;162:105565. doi: 10.1016/j.nbd.2021.105565. Epub 2021 Nov 25. Neurobiol Dis. 2022. PMID: 34838664 Free PMC article.
Nevertheless, aTHC severely impaired the endocannabinoid-dependent long-term potentiation in the lateral perforant path in females of both species, and in male mice; this was reliably associated with impaired acquisition of a component of episodic memory that depends on la …
Nevertheless, aTHC severely impaired the endocannabinoid-dependent long-term potentiation in the lateral perforant path in females of …
Pharmacokinetic and pharmacodynamic properties of aerosolized ("vaped") THC in adolescent male and female rats.
Ruiz CM, Torrens A, Lallai V, Castillo E, Manca L, Martinez MX, Justeson DN, Fowler CD, Piomelli D, Mahler SV. Ruiz CM, et al. Among authors: piomelli d. Psychopharmacology (Berl). 2021 Dec;238(12):3595-3605. doi: 10.1007/s00213-021-05976-8. Epub 2021 Sep 8. Psychopharmacology (Berl). 2021. PMID: 34495367 Free PMC article.
RATIONALE: Adolescent exposure to (9)-tetrahydrocannabinol (THC), the psychotropic constituent of cannabis, might affect brain development, and in rodent models leads to long-term behavioral and physiological alterations. Yet, the basic pharmacology of this drug in adolesc …
RATIONALE: Adolescent exposure to (9)-tetrahydrocannabinol (THC), the psychotropic constituent of cannabis, might affect brain development, …
Pharmacokinetic, behavioral, and brain activity effects of Δ9-tetrahydrocannabinol in adolescent male and female rats.
Ruiz CM, Torrens A, Castillo E, Perrone CR, Cevallos J, Inshishian VC, Harder EV, Justeson DN, Huestis MA, Swarup V, Piomelli D, Mahler SV. Ruiz CM, et al. Among authors: piomelli d. Neuropsychopharmacology. 2021 Apr;46(5):959-969. doi: 10.1038/s41386-020-00839-w. Epub 2020 Sep 14. Neuropsychopharmacology. 2021. PMID: 32927465 Free PMC article.
Retrospective human studies suggest that cannabis use during adolescence is linked to long-term negative psychological outcomes, but in such studies it is difficult to distinguish the effects of THC from those of coexisting factors. ...
Retrospective human studies suggest that cannabis use during adolescence is linked to long-term negative psychological outcomes, but …
Effects of fatty acid amide hydrolase inhibitor URB597 in a rat model of trauma-induced long-term anxiety.
Danandeh A, Vozella V, Lim J, Oveisi F, Ramirez GL, Mears D, Wynn G, Piomelli D. Danandeh A, et al. Among authors: piomelli d. Psychopharmacology (Berl). 2018 Nov;235(11):3211-3221. doi: 10.1007/s00213-018-5020-7. Epub 2018 Sep 24. Psychopharmacology (Berl). 2018. PMID: 30251159
OBJECTIVES: Here, we investigated the effects of the globally active FAAH inhibitor URB597 in a rat model of predator stress-induced long-term anxiety. RESULTS: Rats exposed to 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), a chemical constituent of fox feces, developed a pe …
OBJECTIVES: Here, we investigated the effects of the globally active FAAH inhibitor URB597 in a rat model of predator stress-induced long- …
Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats.
Schoch H, Huerta MY, Ruiz CM, Farrell MR, Jung KM, Huang JJ, Campbell RR, Piomelli D, Mahler SV. Schoch H, et al. Among authors: piomelli d. Psychopharmacology (Berl). 2018 Jan;235(1):121-134. doi: 10.1007/s00213-017-4749-8. Epub 2017 Oct 11. Psychopharmacology (Berl). 2018. PMID: 29022083 Free PMC article.
CONCLUSIONS: These results demonstrate that ACRS causes long-term increases in natural reward-seeking behaviors and ECB system function that persist into adulthood, potentially increasing liability to excessive natural reward seeking later in life....
CONCLUSIONS: These results demonstrate that ACRS causes long-term increases in natural reward-seeking behaviors and ECB system functi …
Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus.
Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G. Wang W, et al. Among authors: piomelli d. Cereb Cortex. 2018 Jul 1;28(7):2253-2266. doi: 10.1093/cercor/bhx126. Cereb Cortex. 2018. PMID: 28520937 Free PMC article.
Here, we describe another form of ECB signaling that triggers a novel form of long-term potentiation (LTP) localized to the lateral perforant path (LPP) which conveys semantic information from cortex to hippocampus. ...
Here, we describe another form of ECB signaling that triggers a novel form of long-term potentiation (LTP) localized to the lateral p …
25 results