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Impact of insulin receptor substrate-1 genotypes on platelet reactivity and cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.
Angiolillo DJ, Bernardo E, Zanoni M, Vivas D, Capranzano P, Malerba G, Capodanno D, Prandini P, Pasquali A, Trabetti E, Sabaté M, Jimenez-Quevedo P, Ferreiro JL, Ueno M, Bass TA, Pignatti PF, Fernandez-Ortiz A, Macaya C. Angiolillo DJ, et al. Among authors: pignatti pf. J Am Coll Cardiol. 2011 Jun 28;58(1):30-9. doi: 10.1016/j.jacc.2011.02.040. J Am Coll Cardiol. 2011. PMID: 21700086 Free article.
OBJECTIVES: The aim of this study was to assess the association between genetic variants of the insulin receptor substrate (IRS)-1 gene, platelet function, and long-term outcomes in patients with type 2 diabetes mellitus (DM) and stable coronary artery disease while on asp …
OBJECTIVES: The aim of this study was to assess the association between genetic variants of the insulin receptor substrate (IRS)-1 gene, pla …
Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene.
Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramírez C, Cavallari U, Trabetti E, Sabaté M, Jimenez-Quevedo P, Hernández R, Moreno R, Escaned J, Alfonso F, Bañuelos C, Costa MA, Bass TA, Pignatti PF, Macaya C. Angiolillo DJ, et al. Among authors: pignatti pf. Am J Cardiol. 2005 Oct 15;96(8):1095-9. doi: 10.1016/j.amjcard.2005.06.039. Epub 2005 Aug 29. Am J Cardiol. 2005. PMID: 16214444 Clinical Trial.
Thus, platelet aggregation varied significantly in patients on long-term dual antiplatelet treatment and was increased in T allele carriers of the 807C/T polymorphism of the glycoprotein Ia gene. ...
Thus, platelet aggregation varied significantly in patients on long-term dual antiplatelet treatment and was increased in T allele ca …
Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease.
Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramírez C, Cavallari U, Trabetti E, Sabaté M, Jimenez-Quevedo P, Hernández R, Moreno R, Escaned J, Alfonso F, Bañuelos C, Costa MA, Bass TA, Pignatti PF, Macaya C. Angiolillo DJ, et al. Among authors: pignatti pf. Thromb Res. 2005;116(6):491-7. doi: 10.1016/j.thromres.2005.03.001. Epub 2005 Apr 20. Thromb Res. 2005. PMID: 16181985
MATERIALS AND METHODS: The T744C polymorphism of the P2Y(12) receptor gene was assessed in 119 patients: 36 undergoing coronary stenting receiving a 300 mg loading dose (Group A) and 83 on long-term clopidogrel (75 mg/day) treatment (Group B). Patients were divided into 2 …
MATERIALS AND METHODS: The T744C polymorphism of the P2Y(12) receptor gene was assessed in 119 patients: 36 undergoing coronary stenting rec …
Osteogenesis imperfecta and type-I collagen mutations. A lethal variant caused by a Gly910-->Ala substitution in the alpha 1 (I) chain.
Valli M, Sangalli A, Rossi A, Mottes M, Forlino A, Tenni R, Pignatti PF, Cetta G. Valli M, et al. Among authors: pignatti pf. Eur J Biochem. 1993 Feb 1;211(3):415-9. doi: 10.1111/j.1432-1033.1993.tb17565.x. Eur J Biochem. 1993. PMID: 7679635 Free article.
The chains bearing the point mutation were poorly secreted and short-term pulse experiments showed that the extensive intracellular retention of mutant trimers also impaired the secretion of normal chains. ...
The chains bearing the point mutation were poorly secreted and short-term pulse experiments showed that the extensive intracellular r …