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Chemical activation of SAT1 corrects diet-induced metabolic syndrome.
Castoldi F, Hyvönen MT, Durand S, Aprahamian F, Sauvat A, Malik SA, Baracco EE, Vacchelli E, Opolon P, Signolle N, Lefevre D, Bossut N, Eisenberg T, Dammbrueck C, Pendl T, Kremer M, Lachkar S, Einer C, Michalke B, Zischka H, Madeo F, Keinänen TA, Maiuri MC, Pietrocola F, Kroemer G. Castoldi F, et al. Among authors: pietrocola f. Cell Death Differ. 2020 Oct;27(10):2904-2920. doi: 10.1038/s41418-020-0550-z. Epub 2020 May 6. Cell Death Differ. 2020. PMID: 32376874 Free PMC article.
Here, we report the finding that triethylenetetramine dihydrochloride (TETA), a copper-chelator agent that can be safely administered to patients for the long-term treatment of Wilson disease, exerts therapeutic benefits in animals challenged with hypercaloric dietary regi …
Here, we report the finding that triethylenetetramine dihydrochloride (TETA), a copper-chelator agent that can be safely administered to pat …
Lysosomal trapping of palbociclib and its functional implications.
Llanos S, Megias D, Blanco-Aparicio C, Hernández-Encinas E, Rovira M, Pietrocola F, Serrano M. Llanos S, et al. Among authors: pietrocola f. Oncogene. 2019 May;38(20):3886-3902. doi: 10.1038/s41388-019-0695-8. Epub 2019 Jan 28. Oncogene. 2019. PMID: 30692638 Free PMC article.
In particular, a short exposure of cells to palbociclib is sufficient to produce a stable cell-cycle arrest and long-term senescence. Moreover, after washing out the drug, palbociclib-treated cells release the drug to the medium and this conditioned medium is active on sus …
In particular, a short exposure of cells to palbociclib is sufficient to produce a stable cell-cycle arrest and long-term senescence. …
Systemic autophagy in the therapeutic response to anthracycline-based chemotherapy.
Castoldi F, Vacchelli E, Zitvogel L, Maiuri MC, Pietrocola F, Kroemer G. Castoldi F, et al. Among authors: pietrocola f. Oncoimmunology. 2018 Oct 1;8(1):e1498285. doi: 10.1080/2162402X.2018.1498285. eCollection 2019. Oncoimmunology. 2018. PMID: 30546941 Free PMC article.
Here, we show that the immune response induced by inoculation of cancer cells undergoing ICD in response to the anthracycline mitoxantrone (MTX) can be improved by a short-term fasting regimen (48 hours of starvation) and that this effect is reversed by systemic administra …
Here, we show that the immune response induced by inoculation of cancer cells undergoing ICD in response to the anthracycline mitoxantrone ( …
Inhibition of formyl peptide receptor 1 reduces the efficacy of anticancer chemotherapy against carcinogen-induced breast cancer.
Baracco EE, Pietrocola F, Buqué A, Bloy N, Senovilla L, Zitvogel L, Vacchelli E, Kroemer G. Baracco EE, et al. Among authors: pietrocola f. Oncoimmunology. 2016 Feb 18;5(6):e1139275. doi: 10.1080/2162402X.2016.1139275. eCollection 2016 Jun. Oncoimmunology. 2016. PMID: 27471610 Free PMC article.
This effect may be attributed to the fact that chemotherapy-induced antitumor immunity requires FPR1 and that such anticancer immune responses are responsible for the long-term effects of chemotherapy. Here, we investigated the possible contribution of FPR1 to the efficacy …
This effect may be attributed to the fact that chemotherapy-induced antitumor immunity requires FPR1 and that such anticancer immune respons …
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Pietrocola F, Pol J, Vacchelli E, Rao S, Enot DP, Baracco EE, Levesque S, Castoldi F, Jacquelot N, Yamazaki T, Senovilla L, Marino G, Aranda F, Durand S, Sica V, Chery A, Lachkar S, Sigl V, Bloy N, Buque A, Falzoni S, Ryffel B, Apetoh L, Di Virgilio F, Madeo F, Maiuri MC, Zitvogel L, Levine B, Penninger JM, Kroemer G. Pietrocola F, et al. Cancer Cell. 2016 Jul 11;30(1):147-160. doi: 10.1016/j.ccell.2016.05.016. Cancer Cell. 2016. PMID: 27411589 Free PMC article.
Treatment with the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cells (which dampen anticancer immunity) from autophagy-competent, but not autophagy-deficient, mutant KRAS-induced lung cancers in mice, thereby improving anticancer i …
Treatment with the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cells (which dampen anticanc …
Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers.
Mariño G, Pietrocola F, Madeo F, Kroemer G. Mariño G, et al. Among authors: pietrocola f. Autophagy. 2014;10(11):1879-82. doi: 10.4161/auto.36413. Autophagy. 2014. PMID: 25484097 Free PMC article.
Here, we speculate that CRM may mediate their broad health-improving effects by triggering the same molecular pathways that usually are elicited by long-term caloric restriction or short-term starvation and that imply the induction of autophagy as an obligatory even …
Here, we speculate that CRM may mediate their broad health-improving effects by triggering the same molecular pathways that usually are elic …