Pulmonary delivery of intratracheally instilled and aerosolized cyclosporine A to young and adult rats.
Taljanski W, Pierzynowski SG, Lundin PD, Westrom BR, Eirefelt S, Podlesny J, Dahlback M, Siwinska-Golebiowska H, Karlsson BW.
Taljanski W, et al. Among authors: pierzynowski sg.
Drug Metab Dispos. 1997 Aug;25(8):917-20.
Drug Metab Dispos. 1997.
PMID: 9280398
Thus, CyA is absorbed by the lungs into the systemic circulation of the rat in high amounts, independent of age and type of delivery system. Long-term treatment with i.t. instillations did not affect body weight gain in young and adult rats, and no histopathological change …
Thus, CyA is absorbed by the lungs into the systemic circulation of the rat in high amounts, independent of age and type of delivery system. …