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Anti-inflammatory Therapy Protects Spiral Ganglion Neurons After Aminoglycoside Antibiotic-Induced Hair Cell Loss.
Rahman MT, Bailey EM, Gansemer BM, Pieper AA, Manak JR, Green SH. Rahman MT, et al. Among authors: pieper aa. Neurotherapeutics. 2023 Mar;20(2):578-601. doi: 10.1007/s13311-022-01336-2. Epub 2023 Jan 25. Neurotherapeutics. 2023. PMID: 36697994 Free PMC article.
Treatment with the anti-inflammatory medications dexamethasone and ibuprofen diminished long-term SGN degeneration. Ibuprofen and dexamethasone also diminished macrophage activation. ...
Treatment with the anti-inflammatory medications dexamethasone and ibuprofen diminished long-term SGN degeneration. Ibuprofen and dex …
A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatment.
Pak TK, Carter CS, Zhang Q, Huang SC, Searby C, Hsu Y, Taugher RJ, Vogel T, Cychosz CC, Genova R, Moreira NN, Stevens H, Wemmie JA, Pieper AA, Wang K, Sheffield VC. Pak TK, et al. Among authors: pieper aa. PLoS Genet. 2021 Apr 22;17(4):e1009484. doi: 10.1371/journal.pgen.1009484. eCollection 2021 Apr. PLoS Genet. 2021. PMID: 33886537 Free PMC article.
Analyses indicated that these behavioral impairments are not the result of impaired hippocampal long-term potentiation. However, our results indicate that these behavioral impairments are the result of impaired hippocampal neurogenesis. ...Overall, our results identify a n …
Analyses indicated that these behavioral impairments are not the result of impaired hippocampal long-term potentiation. However, our …
Different forms of traumatic brain injuries cause different tactile hypersensitivity profiles.
Wattiez AS, Castonguay WC, Gaul OJ, Waite JS, Schmidt CM, Reis AS, Rea BJ, Sowers LP, Cintrón-Pérez CJ, Vázquez-Rosa E, Pieper AA, Russo AF. Wattiez AS, et al. Among authors: pieper aa. Pain. 2021 Apr 1;162(4):1163-1175. doi: 10.1097/j.pain.0000000000002103. Pain. 2021. PMID: 33027220 Free PMC article.
We show that multimodal traumatic brain injury, administered by a jet-flow overpressure chamber that delivers a severe compressive impulse accompanied by a variable shock front and acceleration-deceleration insult, produces long-term tactile hypersensitivity and widespread …
We show that multimodal traumatic brain injury, administered by a jet-flow overpressure chamber that delivers a severe compressive impulse a …
Loss of Cav1.2 channels impairs hippocampal theta burst stimulation-induced long-term potentiation.
Sridharan PS, Lu Y, Rice RC, Pieper AA, Rajadhyaksha AM. Sridharan PS, et al. Among authors: pieper aa. Channels (Austin). 2020 Dec;14(1):287-293. doi: 10.1080/19336950.2020.1807851. Channels (Austin). 2020. PMID: 32799605 Free PMC article.
A role forLTCCs, and Ca(v)1.2 in particular, in transcription-dependent late long-term potentiation (LTP) has long been known. Here, we report that elimination of Ca(v)1.2 channels in glutamatergic neurons also impairs theta burst stimulation (TBS)-induced LTP in the hippo …
A role forLTCCs, and Ca(v)1.2 in particular, in transcription-dependent late long-term potentiation (LTP) has long been known. Here, …
Dopamine D1R-neuron cacna1c deficiency: a new model of extinction therapy-resistant post-traumatic stress.
Bavley CC, Kabir ZD, Walsh AP, Kosovsky M, Hackett J, Sun H, Vázquez-Rosa E, Cintrón-Pérez CJ, Miller E, Koh Y, Pieper AA, Rajadhyaksha AM. Bavley CC, et al. Among authors: pieper aa. Mol Psychiatry. 2021 Jun;26(6):2286-2298. doi: 10.1038/s41380-020-0730-8. Epub 2020 Apr 24. Mol Psychiatry. 2021. PMID: 32332995 Free PMC article.
Post-traumatic stress disorder (PTSD) is characterized by persistent fear memory of remote traumatic events, mental re-experiencing of the trauma, long-term cognitive deficits, and PTSD-associated hippocampal dysfunction. ...
Post-traumatic stress disorder (PTSD) is characterized by persistent fear memory of remote traumatic events, mental re-experiencing of the t …
Ca2+-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity.
Yang T, Britt JK, Cintrón-Pérez CJ, Vázquez-Rosa E, Tobin KV, Stalker G, Hardie J, Taugher RJ, Wemmie J, Pieper AA, Lee A. Yang T, et al. Among authors: pieper aa. Neuroscience. 2018 Jun 1;380:90-102. doi: 10.1016/j.neuroscience.2018.04.004. Epub 2018 Apr 14. Neuroscience. 2018. PMID: 29660444 Free PMC article.
In addition, the number of adult-born neurons in the hippocampus of C-KO mice was 40% of that in WT mice, as measured by bromodeoxyuridine labeling. Moreover, hippocampal long-term potentiation was significantly reduced in C-KO mice. We conclude that CaBP1 is required for …
In addition, the number of adult-born neurons in the hippocampus of C-KO mice was 40% of that in WT mice, as measured by bromodeoxyuridine l …
D-cycloserine improves synaptic transmission in an animal model of Rett syndrome.
Na ES, De Jesús-Cortés H, Martinez-Rivera A, Kabir ZD, Wang J, Ramesh V, Onder Y, Rajadhyaksha AM, Monteggia LM, Pieper AA. Na ES, et al. Among authors: pieper aa. PLoS One. 2017 Aug 16;12(8):e0183026. doi: 10.1371/journal.pone.0183026. eCollection 2017. PLoS One. 2017. PMID: 28813484 Free PMC article.
Here, we show that Mecp2tm1.1Jae/y mice display lower presynaptic function as assessed by paired pulse ratio, as well as decreased long term potentiation (LTP) at hippocampal Schaffer-collateral-CA1 synapses. ...
Here, we show that Mecp2tm1.1Jae/y mice display lower presynaptic function as assessed by paired pulse ratio, as well as decreased long t …
Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury.
Blaya MO, Bramlett HM, Naidoo J, Pieper AA, Dietrich WD. Blaya MO, et al. Among authors: pieper aa. J Neurotrauma. 2014 Mar 1;31(5):476-86. doi: 10.1089/neu.2013.3135. Epub 2013 Dec 19. J Neurotrauma. 2014. PMID: 24070637 Free PMC article.
Traumatic brain injury (TBI) is characterized by histopathological damage and long-term sensorimotor and cognitive dysfunction. Recent studies have reported the discovery of the P7C3 class of aminopropyl carbazole agents with potent neuroprotective properties for both newb …
Traumatic brain injury (TBI) is characterized by histopathological damage and long-term sensorimotor and cognitive dysfunction. Recen …