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Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort.
Wong K, Pitcher D, Braddon F, Downward L, Steenkamp R, Annear N, Barratt J, Bingham C, Chrysochou C, Coward RJ, Game D, Griffin S, Hall M, Johnson S, Kanigicherla D, Karet Frankl F, Kavanagh D, Kerecuk L, Maher ER, Moochhala S, Pinney J, Sayer JA, Simms R, Sinha S, Srivastava S, Tam FWK, Turner AN, Walsh SB, Waters A, Wilson P, Wong E, Taylor CM, Nitsch D, Saleem M, Bockenhauer D, Bramham K, Gale DP; RaDaR consortium. Wong K, et al. Lancet. 2024 Mar 30;403(10433):1279-1289. doi: 10.1016/S0140-6736(23)02843-X. Epub 2024 Mar 13. Lancet. 2024. PMID: 38492578 Free article.
Addressing unmet therapeutic need for patients with rare kidney diseases could have a large beneficial effect on long-term kidney replacement therapy demand. FUNDING: RaDaR is funded by the Medical Research Council, Kidney Research UK, Kidney Care UK, and the Polycystic Ki …
Addressing unmet therapeutic need for patients with rare kidney diseases could have a large beneficial effect on long-term kidney rep …
Glucocorticoid trajectories over 2 years in patients with rheumatoid arthritis in a real-life setting.
Delteil A, Lambert C, Pereira B, Couderc M, Malochet-Guinamand S, Pickering ME, Villedon M, Mathieu S, Soubrier M, Tournadre A. Delteil A, et al. Among authors: pickering me. RMD Open. 2023 Oct;9(4):e003366. doi: 10.1136/rmdopen-2023-003366. RMD Open. 2023. PMID: 37880179 Free PMC article.
CONCLUSION: GCs were used in almost half of patients with established RA in real-world practice. For the majority of GC users, a long-term low dose of GCs is maintained over 2 years. These results highlight the difficulties with stopping GCs, the lack of consensus for the …
CONCLUSION: GCs were used in almost half of patients with established RA in real-world practice. For the majority of GC users, a long-ter …
Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice.
Kamala O, Malik TH, Hallam TM, Cox TE, Yang Y, Vyas F, Luli S, Connelly C, Gibson B, Smith-Jackson K, Denton H, Pappworth IY, Huang L, Kavanagh D, Pickering MC, Marchbank KJ. Kamala O, et al. Among authors: pickering mc. Front Immunol. 2021 Dec 9;12:752916. doi: 10.3389/fimmu.2021.752916. eCollection 2021. Front Immunol. 2021. PMID: 34956184 Free PMC article.
Herein, we describe the production of a murine version of homodimeric mini-FH [mHDM-FH (mFH(1-5^18-20^R1-2))], developed to reduce the risk of anti-drug antibody formation during long-term experiments in murine models of C3G and other complement-driven pathologies. ...
Herein, we describe the production of a murine version of homodimeric mini-FH [mHDM-FH (mFH(1-5^18-20^R1-2))], developed to reduce the risk …
C3 Glomerulopathy and Related Disorders in Children: Etiology-Phenotype Correlation and Outcomes.
Wong EKS, Marchbank KJ, Lomax-Browne H, Pappworth IY, Denton H, Cooke K, Ward S, McLoughlin AC, Richardson G, Wilson V, Harris CL, Morgan BP, Hakobyan S, McAlinden P, Gale DP, Maxwell H, Christian M, Malcomson R, Goodship THJ, Marks SD, Pickering MC, Kavanagh D, Cook HT, Johnson SA; MPGN/DDD/C3 Glomerulopathy Rare Disease Group and National Study of MPGN/DDD/C3 Glomerulopathy Investigators. Wong EKS, et al. Among authors: pickering mc. Clin J Am Soc Nephrol. 2021 Nov;16(11):1639-1651. doi: 10.2215/CJN.00320121. Epub 2021 Sep 22. Clin J Am Soc Nephrol. 2021. PMID: 34551983 Free PMC article.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A total of 80 prevalent pediatric patients with membranoproliferative GN/C3 glomerulopathy underwent detailed phenotyping and long-term follow-up within the National Registry of Rare Kidney Diseases (RaDaR). ...
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A total of 80 prevalent pediatric patients with membranoproliferative GN/C3 glomerulopath …
Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.
Merle NS, Leon J, Poillerat V, Grunenwald A, Boudhabhay I, Knockaert S, Robe-Rybkine T, Torset C, Pickering MC, Chauvet S, Fremeaux-Bacchi V, Roumenina LT. Merle NS, et al. Among authors: pickering mc. Front Immunol. 2020 Aug 7;11:1772. doi: 10.3389/fimmu.2020.01772. eCollection 2020. Front Immunol. 2020. PMID: 32849636 Free PMC article.
Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.
Smith-Jackson K, Yang Y, Denton H, Pappworth IY, Cooke K, Barlow PN, Atkinson JP, Liszewski MK, Pickering MC, Kavanagh D, Cook HT, Marchbank KJ. Smith-Jackson K, et al. Among authors: pickering mc. J Clin Invest. 2019 Mar 1;129(3):1061-1075. doi: 10.1172/JCI99296. Epub 2019 Feb 4. J Clin Invest. 2019. PMID: 30714990 Free PMC article.
Thus, our data provide in vivo modeling evidence that gain-of-function changes in complement C3 drive aHUS. They also show that long-term C5 deficiency is not accompanied by development of other renal complications (such as C3 glomerulopathy) despite sustained dysregulatio …
Thus, our data provide in vivo modeling evidence that gain-of-function changes in complement C3 drive aHUS. They also show that long-term …
Non-rigid registration of cervical spine MRI volumes.
Aktar MN, Alam MJ, Pickering M, Webb A, Perriman D. Aktar MN, et al. Among authors: pickering m. Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:1997-2000. doi: 10.1109/EMBC.2015.7318777. Annu Int Conf IEEE Eng Med Biol Soc. 2015. PMID: 26736677
Whiplash is the colloquial term for neck injuries caused by sudden extension of the cervical spine. ...
Whiplash is the colloquial term for neck injuries caused by sudden extension of the cervical spine. ...
Luminosity determination in pp collisions at [Formula: see text] = 8 TeV using the ATLAS detector at the LHC.
Aaboud M, Aad G, Abbott B, Abdallah J, Abdinov O, Abeloos B, Aben R, AbouZeid OS, Abraham NL, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, Adelman J, Adomeit S, Adye T, Affolder AA, Agatonovic-Jovin T, Agricola J, Aguilar-Saavedra JA, Ahlen SP, Ahmadov F, Aielli G, Akerstedt H, Åkesson TPA, Akimov AV, Alberghi GL, Albert J, Albrand S, Verzini MJA, Aleksa M, Aleksandrov IN, Alexa C, Alexander G, Alexopoulos T, Alhroob M, Aliev M, Alimonti G, Alison J, Alkire SP, Allbrooke BMM, Allen BW, Allport PP, Aloisio A, Alonso A, Alonso F, Alpigiani C, Alstaty M, Gonzalez BA, Piqueras DÁ, Alviggi MG, Amadio BT, Amako K, Coutinho YA, Amelung C, Amidei D, Santos SPAD, Amorim A, Amoroso S, Amundsen G, Anastopoulos C, Ancu LS, Andari N, Andeen T, Anders CF, Anders G, Anders JK, Anderson KJ, Andreazza A, Andrei V, Angelidakis S, Angelozzi I, Anger P, Angerami A, Anghinolfi F, Anisenkov AV, Anjos N, Annovi A, Antonelli M, Antonov A, Anulli F, Aoki M, Bella LA, Arabidze G, Arai Y, Araque JP, Arce ATH, Arduh FA, Arguin JF, Argyropoulos S, Arik M, Armbruster AJ, Armitage LJ, Arnaez O, Arnold H, Arratia M, Arslan O, Artamonov A, Artoni G, Artz S, Asai S, Asbah N, Ashken… See abstract for full author list ➔ Aaboud M, et al. Among authors: pickering ma. Eur Phys J C Part Fields. 2016;76(12):653. doi: 10.1140/epjc/s10052-016-4466-1. Epub 2016 Nov 28. Eur Phys J C Part Fields. 2016. PMID: 28316496 Free PMC article.
The evaluation of the luminosity scale is performed using several luminometers, and comparisons between these luminosity detectors are made to assess the accuracy, consistency and long-term stability of the results. A luminosity uncertainty of [Formula: see text] is obtain …
The evaluation of the luminosity scale is performed using several luminometers, and comparisons between these luminosity detectors are made …
33 results