Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

14 results

Filters applied: . Clear all
Page 1
Dynamic full-field optical coherence tomography module adapted to commercial microscopes allows longitudinal in vitro cell culture study.
Monfort T, Azzollini S, Brogard J, Clémençon M, Slembrouck-Brec A, Forster V, Picaud S, Goureau O, Reichman S, Thouvenin O, Grieve K. Monfort T, et al. Among authors: picaud s. Commun Biol. 2023 Sep 28;6(1):992. doi: 10.1038/s42003-023-05378-w. Commun Biol. 2023. PMID: 37770552 Free PMC article.
Here, a D-FFOCT module design is presented which can be coupled to a commercial microscope with a stage top incubator, allowing non-invasive label-free longitudinal imaging over periods of minutes to weeks on the same sample. Long term volumetric imaging on human induced p …
Here, a D-FFOCT module design is presented which can be coupled to a commercial microscope with a stage top incubator, allowing non-invasive …
Adaptive Optics Flood Illumination Ophthalmoscopy in Nonhuman Primates: Findings in Normal and Short-term Induced Detached Retinae.
Dentel A, Brazhnikova E, Norberg N, Jaillard C, Grieve K, Paques M, Sahel JA, Bertin S, Forster V, Picaud S. Dentel A, et al. Among authors: picaud s. Ophthalmol Sci. 2023 Apr 20;3(4):100316. doi: 10.1016/j.xops.2023.100316. eCollection 2023 Dec. Ophthalmol Sci. 2023. PMID: 37274010 Free PMC article.
OBJECTIVE: To describe adaptive optics flood illumination ophthalmoscopy (AO-FIO) of the photoreceptor layer in normal nonhuman primates (NHPs) and in the case of a short-term induced retinal detachment (RD). DESIGN: Longitudinal fundamental research study. ...
OBJECTIVE: To describe adaptive optics flood illumination ophthalmoscopy (AO-FIO) of the photoreceptor layer in normal nonhuman primates (NH …
Failed remyelination of the nonhuman primate optic nerve leads to axon degeneration, retinal damages, and visual dysfunction.
Sarrazin N, Chavret-Reculon E, Bachelin C, Felfli M, Arab R, Gilardeau S, Brazhnikova E, Dubus E, Yaha-Cherif L, Lorenceau J, Picaud S, Rosolen S, Moissonnier P, Pouget P, Baron-Van Evercooren A. Sarrazin N, et al. Among authors: picaud s. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2115973119. doi: 10.1073/pnas.2115973119. Epub 2022 Mar 2. Proc Natl Acad Sci U S A. 2022. PMID: 35235463 Free PMC article.
Thus, well-defined nonhuman primate models are required to efficiently advance therapeutic approaches for patients. Here, we followed the consequence of long-term toxin-induced demyelination of the macaque optic nerve on remyelination and axon preservation, as well as its …
Thus, well-defined nonhuman primate models are required to efficiently advance therapeutic approaches for patients. Here, we followed the co …
In vivo optogenetic stimulation of the primate retina activates the visual cortex after long-term transduction.
Chaffiol A, Provansal M, Joffrois C, Blaize K, Labernede G, Goulet R, Burban E, Brazhnikova E, Duebel J, Pouget P, Sahel JA, Picaud S, Arcizet F, Gauvain G. Chaffiol A, et al. Among authors: picaud s. Mol Ther Methods Clin Dev. 2021 Nov 22;24:1-10. doi: 10.1016/j.omtm.2021.11.009. eCollection 2022 Mar 10. Mol Ther Methods Clin Dev. 2021. PMID: 34977267 Free PMC article.
But applications to human patients suffering from retinal diseases leading to blindness raise important concerns on the long-term functional expression of optogenes and the efficient signal transmission to higher visual centers. ...Using synaptic blockers, we isolated the …
But applications to human patients suffering from retinal diseases leading to blindness raise important concerns on the long-term fun …
Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation.
Losada PG, Rousseau L, Grzeskowiak M, Valet M, Nguyen D, Dégardin J, Dubus E, Picaud S, Lissorgues G. Losada PG, et al. Among authors: picaud s. Front Neurosci. 2019 Aug 27;13:885. doi: 10.3389/fnins.2019.00885. eCollection 2019. Front Neurosci. 2019. PMID: 31507363 Free PMC article.
While designing such a neural interface, several aspects must be taken into account, like the stimulation efficiency related to the current distribution within the tissue, the bio-interface optimization to improve resolution and tissue integration, and the material biocompatibili …
While designing such a neural interface, several aspects must be taken into account, like the stimulation efficiency related to the current …
Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina.
Ameline B, Tshilenge KT, Weber M, Biget M, Libeau L, Caplette R, Mendes-Madeira A, Provost N, Guihal C, Picaud S, Moullier P, Pichard V, Cronin T, Isiegas C. Ameline B, et al. Among authors: picaud s. Gene Ther. 2017 Nov;24(11):735-741. doi: 10.1038/gt.2017.63. Epub 2017 Sep 7. Gene Ther. 2017. PMID: 28880021
In the present study, we assessed the potentially deleterious effects of long-term expression of these optogenes on the diseased retina in a large animal model of retinal degeneration, the RPE65-deficient Briard dog model of Leber congenital amaurosis. ...
In the present study, we assessed the potentially deleterious effects of long-term expression of these optogenes on the diseased reti …
3D-nanostructured boron-doped diamond for microelectrode array neural interfacing.
Piret G, Hébert C, Mazellier JP, Rousseau L, Scorsone E, Cottance M, Lissorgues G, Heuschkel MO, Picaud S, Bergonzo P, Yvert B. Piret G, et al. Among authors: picaud s. Biomaterials. 2015 Jun;53:173-83. doi: 10.1016/j.biomaterials.2015.02.021. Epub 2015 Mar 13. Biomaterials. 2015. PMID: 25890717 Free article.
The electrode material is a key element in the design of long-term neural implants and neuroprostheses. To date, the ideal electrode material offering high longevity, biocompatibility, low-noise recording and high stimulation capabilities remains to be found. ...In particu …
The electrode material is a key element in the design of long-term neural implants and neuroprostheses. To date, the ideal electrode …
Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV Restores ON and OFF visual responses in blind mice.
Macé E, Caplette R, Marre O, Sengupta A, Chaffiol A, Barbe P, Desrosiers M, Bamberg E, Sahel JA, Picaud S, Duebel J, Dalkara D. Macé E, et al. Among authors: picaud s. Mol Ther. 2015 Jan;23(1):7-16. doi: 10.1038/mt.2014.154. Epub 2014 Aug 6. Mol Ther. 2015. PMID: 25095892 Free PMC article.
We show that AAV encoding channelrhodopsin under the ON bipolar cell-specific promoter mediates long-term gene delivery restricted to ON-bipolar cells after intravitreal administration. ...
We show that AAV encoding channelrhodopsin under the ON bipolar cell-specific promoter mediates long-term gene delivery restricted to …
Long-term in vivo impedance changes of subretinal microelectrodes implanted in dystrophic P23H rats.
Linderholm P, Guyomard JL, Djilas M, Salzmann J, Simonutti M, Sahel JA, Safran AB, Renaud P, Picaud S. Linderholm P, et al. Among authors: picaud s. Int J Artif Organs. 2013 Oct 3;36(9):612-9. doi: 10.5301/ijao.5000213. Epub 2013 May 31. Int J Artif Organs. 2013. PMID: 23918262
Electrodes arrays were subretinally implanted in transgenic P23H rats with their photoreceptors degenerated. Electrical stability of the implants was evaluated by long-term monitoring of their impedance changes. Electrode impedances were found to increase by two log units …
Electrodes arrays were subretinally implanted in transgenic P23H rats with their photoreceptors degenerated. Electrical stability of the imp …
A review of in vivo animal studies in retinal prosthesis research.
Bertschinger DR, Beknazar E, Simonutti M, Safran AB, Sahel JA, Rosolen SG, Picaud S, Salzmann J. Bertschinger DR, et al. Among authors: picaud s. Graefes Arch Clin Exp Ophthalmol. 2008 Nov;246(11):1505-17. doi: 10.1007/s00417-008-0891-7. Epub 2008 Aug 16. Graefes Arch Clin Exp Ophthalmol. 2008. PMID: 18709385 Review.
CONCLUSION: The contribution of animal models to the development of retinal prosthetic devices has been enormous, and has led to human feasibility studies. Grey areas remain regarding long-term tissue-implant interactions, biomaterials, prosthesis design and neural adaptat …
CONCLUSION: The contribution of animal models to the development of retinal prosthetic devices has been enormous, and has led to human feasi …
14 results