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Depressive symptoms improve over 2 years of type 2 diabetes treatment via a digital continuous remote care intervention focused on carbohydrate restriction.
Adams RN, Athinarayanan SJ, McKenzie AL, Hallberg SJ, McCarter JP, Phinney SD, Gonzalez JS. Adams RN, et al. Among authors: phinney sd. J Behav Med. 2022 Jun;45(3):416-427. doi: 10.1007/s10865-021-00272-4. Epub 2022 Jan 27. J Behav Med. 2022. PMID: 35084637 Free PMC article.
Carbohydrate restriction is an effective treatment for T2D but its long-term impacts on depressive symptoms are unclear. In the current study we explored changes in depressive symptoms over 2 years among 262 primarily non-depressed T2D patients participating in a continuou …
Carbohydrate restriction is an effective treatment for T2D but its long-term impacts on depressive symptoms are unclear. In the curre …
Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial.
Athinarayanan SJ, Adams RN, Hallberg SJ, McKenzie AL, Bhanpuri NH, Campbell WW, Volek JS, Phinney SD, McCarter JP. Athinarayanan SJ, et al. Among authors: phinney sd. Front Endocrinol (Lausanne). 2019 Jun 5;10:348. doi: 10.3389/fendo.2019.00348. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 31231311 Free PMC article.

Purpose: Studies on long-term sustainability of low-carbohydrate approaches to treat diabetes are limited. ...All the reported improvements had p < 0.00012. Conclusion: The CCI group sustained long-term beneficial effects on multiple clinical markers of diabetes

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Purpose: Studies on long-term sustainability of low-carbohydrate approaches to treat diabetes are limited. ...All the reported improv …
Metabolic characteristics of keto-adapted ultra-endurance runners.
Volek JS, Freidenreich DJ, Saenz C, Kunces LJ, Creighton BC, Bartley JM, Davitt PM, Munoz CX, Anderson JM, Maresh CM, Lee EC, Schuenke MD, Aerni G, Kraemer WJ, Phinney SD. Volek JS, et al. Among authors: phinney sd. Metabolism. 2016 Mar;65(3):100-10. doi: 10.1016/j.metabol.2015.10.028. Epub 2015 Nov 2. Metabolism. 2016. PMID: 26892521 Free article.
CONCLUSION: Compared to highly trained ultra-endurance athletes consuming an HC diet, long-term keto-adaptation results in extraordinarily high rates of fat oxidation, whereas muscle glycogen utilization and repletion patterns during and after a 3 hour run are similar....
CONCLUSION: Compared to highly trained ultra-endurance athletes consuming an HC diet, long-term keto-adaptation results in extraordin …
Weight loss with self-help compared with a structured commercial program: a randomized trial.
Heshka S, Anderson JW, Atkinson RL, Greenway FL, Hill JO, Phinney SD, Kolotkin RL, Miller-Kovach K, Pi-Sunyer FX. Heshka S, et al. Among authors: phinney sd. JAMA. 2003 Apr 9;289(14):1792-8. doi: 10.1001/jama.289.14.1792. JAMA. 2003. PMID: 12684357 Clinical Trial.
CONTEXT: Although commercial weight loss programs provide treatment to millions of clients, their efficacy has not been evaluated in rigorous long-term trials. OBJECTIVE: To compare weight loss and health benefits achieved and maintained through self-help weight loss vs wi …
CONTEXT: Although commercial weight loss programs provide treatment to millions of clients, their efficacy has not been evaluated in rigorou …
Increased hepatic delta 6-desaturase activity with growth hormone expression in the MG101 transgenic mouse.
Nakamura MT, Phinney SD, Tang AB, Oberbauer AM, German JB, Murray JD. Nakamura MT, et al. Among authors: phinney sd. Lipids. 1996 Feb;31(2):139-43. doi: 10.1007/BF02522612. Lipids. 1996. PMID: 8835400
Growth hormone (GH) has many metabolic effects, but its mechanism(s) of action are not fully understood. We studied the short-term effects of endogenously produced GH on liver delta 6-desaturase activity and adipose and liver lipid fraction fatty acid composition in transg …
Growth hormone (GH) has many metabolic effects, but its mechanism(s) of action are not fully understood. We studied the short-term ef …
Is there a role for parenteral feeding in clinical medicine?
Phinney SD, Siepler J, Bach HT. Phinney SD, et al. West J Med. 1996 Feb;164(2):130-6. West J Med. 1996. PMID: 8775726 Free PMC article. Review.
Total parenteral nutrition was developed to halt or reverse this disorder, but its ability to improve the short- to intermediate-term outcome in patients with impaired nutrient intake has been highly inconsistent. ...
Total parenteral nutrition was developed to halt or reverse this disorder, but its ability to improve the short- to intermediate-term …
The body composition and lipid metabolic effects of long-term ethanol feeding during a high omega 6 polyunsaturated fatty acid diet in micropigs.
Nakamura MT, Tang AB, Villanueva J, Halsted CH, Phinney SD. Nakamura MT, et al. Among authors: phinney sd. Metabolism. 1993 Oct;42(10):1340-50. doi: 10.1016/0026-0495(93)90136-c. Metabolism. 1993. PMID: 8412749
Our previous research with miniature pigs has shown that long-term ethanol feeding with a low-fat diet decreases arachidonic acid (20:4 omega 6) levels in multiple tissues, but we did not find significant liver pathology. ...
Our previous research with miniature pigs has shown that long-term ethanol feeding with a low-fat diet decreases arachidonic acid (20 …
Exercise during and after very-low-calorie dieting.
Phinney SD. Phinney SD. Am J Clin Nutr. 1992 Jul;56(1 Suppl):190S-194S. doi: 10.1093/ajcn/56.1.190S. Am J Clin Nutr. 1992. PMID: 1615882 Review.
Although it is logical that they be combined in the context of multidisciplinary treatment, restrictions in calorie or protein intakes while dieting may impair short-term or long-term function. The limited evidence available indicates that properly constituted very- …
Although it is logical that they be combined in the context of multidisciplinary treatment, restrictions in calorie or protein intakes while …
Plasma and urinary carnitine of obese subjects on very-low-calorie diets.
Davis AT, Davis PG, Phinney SD. Davis AT, et al. Among authors: phinney sd. J Am Coll Nutr. 1990 Jun;9(3):261-4. doi: 10.1080/07315724.1990.10720378. J Am Coll Nutr. 1990. PMID: 2358621
Subjects receiving D1 excreted significantly less urinary carnitine than those receiving D2. We conclude that long-term ingestion of very-low-calorie diets causes alterations in plasma carnitine metabolism....
Subjects receiving D1 excreted significantly less urinary carnitine than those receiving D2. We conclude that long-term ingestion of …
The management of hypertension associated with obesity.
Sims EA, Phinney SD, Vaswani A. Sims EA, et al. Among authors: phinney sd. Int J Obes. 1978;2(2):215-23. Int J Obes. 1978. PMID: 711366
Controlled studies are needed to determine whether there may be particular subtypes of obesity which respond more favorably to such management and to evaluate the long-term benefits of the dietary approach....
Controlled studies are needed to determine whether there may be particular subtypes of obesity which respond more favorably to such manageme …