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First-in-human study of WT1 recombinant protein vaccination in elderly patients with AML in remission: a single-center experience.
Kreutmair S, Pfeifer D, Waterhouse M, Takács F, Graessel L, Döhner K, Duyster J, Illert AL, Frey AV, Schmitt M, Lübbert M. Kreutmair S, et al. Among authors: pfeifer d. Cancer Immunol Immunother. 2022 Dec;71(12):2913-2928. doi: 10.1007/s00262-022-03202-8. Epub 2022 Apr 27. Cancer Immunol Immunother. 2022. PMID: 35476127 Free PMC article. Clinical Trial.
Clinical benefit was observed in three patients: one patient achieved measurable residual disease clearance during WT1 vaccination therapy, another patient maintained long-term molecular remission over 59 months after the first vaccination cycle. ...
Clinical benefit was observed in three patients: one patient achieved measurable residual disease clearance during WT1 vaccination therapy, …
Kindlin-3 maintains marginal zone B cells but confines follicular B cell activation and differentiation.
Härzschel A, Li L, Krenn PW, Szenes-Nagy E, Andrieux G, Bayer E, Pfeifer D, Polcik L, Denk U, Höpner JP, Karabatak E, Danner DJ, Tangermann S, Kenner L, Jumaa H, Greil R, Börries M, Ruppert R, Maity PC, Hartmann TN. Härzschel A, et al. Among authors: pfeifer d. J Leukoc Biol. 2022 Apr;111(4):745-758. doi: 10.1002/JLB.1HI0621-313R. Epub 2021 Dec 10. J Leukoc Biol. 2022. PMID: 34888947
In Kindlin-3 knockout B cells VLA-4 as well as LFA-1-mediated adhesion was abrogated, and short-term homing of these cells in vivo was redirected to the spleen. ...
In Kindlin-3 knockout B cells VLA-4 as well as LFA-1-mediated adhesion was abrogated, and short-term homing of these cells in vivo wa …
Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model.
Kreutmair S, Klingeberg C, Poggio T, Andrieux G, Keller A, Miething C, Follo M, Pfeifer D, Shoumariyeh K, Lengerke C, Gonzalez-Menendez I, Fend F, Zeiser R, Turner SD, Quintanilla-Martinez L, Boerries M, Duyster J, Illert AL. Kreutmair S, et al. Among authors: pfeifer d. Leukemia. 2020 Dec;34(12):3242-3255. doi: 10.1038/s41375-020-0789-x. Epub 2020 Mar 17. Leukemia. 2020. PMID: 32203142 Free PMC article.
Furthermore, these lymphoma stem cells are characterized by low CD30 expression levels, which might contribute to limited long-term therapeutic success in patients treated with anti-CD30-targeted therapies. ...
Furthermore, these lymphoma stem cells are characterized by low CD30 expression levels, which might contribute to limited long-term t …
Long-term epilepsy-associated tumors: transcriptional signatures reflect clinical course.
Delev D, Daka K, Heynckes S, Gaebelein A, Franco P, Pfeifer D, Prinz M, Schnell O, Urbach H, Mader I, Beck J, Grote A, Becker AJ, Heiland DH. Delev D, et al. Among authors: pfeifer d. Sci Rep. 2020 Jan 9;10(1):96. doi: 10.1038/s41598-019-56146-y. Sci Rep. 2020. PMID: 31919458 Free PMC article.
Long-term epilepsy-associated tumors (LEATs) represent mostly benign brain tumors associated with drug-resistant epilepsy. ...Our analysis suggests distinct oncological pathomechanisms in long-term epilepsy-associated tumors. Transcriptional activation of MAPK-pathw …
Long-term epilepsy-associated tumors (LEATs) represent mostly benign brain tumors associated with drug-resistant epilepsy. ...Our ana …
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.
Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K… See abstract for full author list ➔ Mathew NR, et al. Among authors: pfeifer d. Nat Med. 2018 Mar;24(3):282-291. doi: 10.1038/nm.4484. Epub 2018 Feb 12. Nat Med. 2018. PMID: 29431743 Free PMC article.
This synergized with the allogeneic CD8(+) T cell response, leading to long-term survival in six mouse models of FLT3-ITD(+) AML. Sorafenib-related IL-15 production caused an increase in CD8(+)CD107a(+)IFN-gamma(+) T cells with features of longevity (high levels of Bcl-2 a …
This synergized with the allogeneic CD8(+) T cell response, leading to long-term survival in six mouse models of FLT3-ITD(+) AML. Sor …
Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia.
Müller-Schmah C, Solari L, Weis R, Pfeifer D, Scheibenbogen C, Trepel M, May AM, Engelhardt R, Lübbert M. Müller-Schmah C, et al. Among authors: pfeifer d. Ann Hematol. 2012 Jan;91(1):27-32. doi: 10.1007/s00277-011-1332-y. Epub 2011 Sep 29. Ann Hematol. 2012. PMID: 21959947
When the patient's natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, implying that long-term CR in this patient could be due to NK cell-mediated disease control....
When the patient's natural killer (NK) cells (obtained in 2007) were tested against the K562 cell line, upregulation of CD107 occurred, impl …
Recurrent strokes under anticoagulation therapy: Sticky platelet syndrome combined with a patent foramen ovale.
Gehoff A, Kluge JG, Gehoff P, Jurisch D, Pfeifer D, Hinz J, Popov AF. Gehoff A, et al. Among authors: pfeifer d. J Cardiovasc Dis Res. 2011 Jan;2(1):68-70. doi: 10.4103/0975-3583.78600. J Cardiovasc Dis Res. 2011. PMID: 21716756 Free PMC article.
We report an unusual case of a 56-year-old female patient with a PFO, who suffered from recurrent strokes despite long-term medication with clopidogrel for SPS. The patient underwent successful transcatheter closure of the PFO, and, in addition, she has been placed on low- …
We report an unusual case of a 56-year-old female patient with a PFO, who suffered from recurrent strokes despite long-term medicatio …
The Calibration Kit Spectral Fluorescence Standards--a simple and certified tool for the standardization of the spectral characteristics of fluorescence instruments.
Pfeifer D, Hoffmann K, Hoffmann A, Monte C, Resch-Genger U. Pfeifer D, et al. J Fluoresc. 2006 Jul;16(4):581-7. doi: 10.1007/s10895-006-0086-8. Epub 2006 Jun 22. J Fluoresc. 2006. PMID: 16791494
With the Calibration Kit Spectral Fluorescence Standards BAM-F001-BAM-F005, we developed a simple tool for the characterization of the relative spectral responsivity and the long-term stability of the emission channel of fluorescence instruments under routine measurement c …
With the Calibration Kit Spectral Fluorescence Standards BAM-F001-BAM-F005, we developed a simple tool for the characterization of the relat …
14 results