Silencing of microRNA families by seed-targeting tiny LNAs.
Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S.
Obad S, et al. Among authors: petri a.
Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786.
Nat Genet. 2011.
PMID: 21423181
Free PMC article.
In addition, systemically delivered, unconjugated tiny LNAs showed uptake in many normal tissues and in breast tumors in mice, coinciding with long-term miRNA silencing. Transcriptional and proteomic profiling suggested that tiny LNAs have negligible off-target effects, no …
In addition, systemically delivered, unconjugated tiny LNAs showed uptake in many normal tissues and in breast tumors in mice, coinciding wi …