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Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension.
Le Ribeuz H, To L, Ghigna MR, Martin C, Nagaraj C, Dreano E, Rucker-Martin C, Girerd B, Bouligand J, Pechoux C, Lambert M, Boet A, Issard J, Mercier O, Hoetzenecker K, Manoury B, Becq F, Burgel PR, Cottart CH, Olschewski A, Sermet-Gaudelus I, Perros F, Humbert M, Montani D, Antigny F. Le Ribeuz H, et al. Among authors: perros f. Eur Respir J. 2021 Nov 25;58(5):2000653. doi: 10.1183/13993003.00653-2020. Print 2021 Nov. Eur Respir J. 2021. PMID: 33926975 Free article.
CFTR-mediated pulmonary artery relaxation was reduced in pulmonary arteries from iPAH patients and rats with monocrotaline- or chronic hypoxia-induced PH. Long-term in vivo CFTR inhibition in rats significantly increased right ventricular systolic pressure, which was relat …
CFTR-mediated pulmonary artery relaxation was reduced in pulmonary arteries from iPAH patients and rats with monocrotaline- or chronic hypox …
Characteristics and Long-term Outcomes of Pulmonary Venoocclusive Disease Induced by Mitomycin C.
Certain MC, Chaumais MC, Jaïs X, Savale L, Seferian A, Parent F, Georges M, Favrolt N, Bourdin A, Boissin C, Cottin V, Traclet J, Renard S, Noel V, Picard F, Girerd B, Ghigna MR, Perros F, Sitbon O, Bonniaud P, Humbert M, Montani D. Certain MC, et al. Among authors: perros f. Chest. 2021 Mar;159(3):1197-1207. doi: 10.1016/j.chest.2020.09.238. Epub 2020 Sep 24. Chest. 2021. PMID: 32979348 Free article.
Pulmonary hypertension associated with neurofibromatosis type 1.
Jutant EM, Girerd B, Jaïs X, Savale L, O'Connell C, Perros F, Sitbon O, Humbert M, Montani D. Jutant EM, et al. Among authors: perros f. Eur Respir Rev. 2018 Aug 29;27(149):180053. doi: 10.1183/16000617.0053-2018. Print 2018 Sep 30. Eur Respir Rev. 2018. PMID: 30158278 Free PMC article. Review.
PH-NF1 was characterised by a female predominance, an advanced age at diagnosis, an association with parenchymal lung disease in two out of three cases and poor long-term prognosis. NF1 is generally associated with interstitial lung disease but some cases of severe PH with …
PH-NF1 was characterised by a female predominance, an advanced age at diagnosis, an association with parenchymal lung disease in two out of …
Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
Sabourin J, Boet A, Rucker-Martin C, Lambert M, Gomez AM, Benitah JP, Perros F, Humbert M, Antigny F. Sabourin J, et al. Among authors: perros f. J Mol Cell Cardiol. 2018 May;118:208-224. doi: 10.1016/j.yjmcc.2018.04.003. Epub 2018 Apr 7. J Mol Cell Cardiol. 2018. PMID: 29634917
The progressive increase of pulmonary vascular resistance induces RV hypertrophy (RVH) and at term RV failure (RVF). However, the molecular mechanisms of RVH and RVF remain understudied. ...
The progressive increase of pulmonary vascular resistance induces RV hypertrophy (RVH) and at term RV failure (RVF). However, the mol …
Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.
Antigny F, Hautefort A, Meloche J, Belacel-Ouari M, Manoury B, Rucker-Martin C, Péchoux C, Potus F, Nadeau V, Tremblay E, Ruffenach G, Bourgeois A, Dorfmüller P, Breuils-Bonnet S, Fadel E, Ranchoux B, Jourdon P, Girerd B, Montani D, Provencher S, Bonnet S, Simonneau G, Humbert M, Perros F. Antigny F, et al. Among authors: perros f. Circulation. 2016 Apr 5;133(14):1371-85. doi: 10.1161/CIRCULATIONAHA.115.020951. Epub 2016 Feb 24. Circulation. 2016. PMID: 26912814
We demonstrated that KCNK3 modulated pulmonary arterial tone. Long-term inhibition of KCNK3 in rats induced distal neomuscularization and early hemodynamic signs of PH, which were related to exaggerated proliferation of pulmonary artery endothelial cells, pulmonary artery …
We demonstrated that KCNK3 modulated pulmonary arterial tone. Long-term inhibition of KCNK3 in rats induced distal neomuscularization …
Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension.
de Man FS, Tu L, Handoko ML, Rain S, Ruiter G, François C, Schalij I, Dorfmüller P, Simonneau G, Fadel E, Perros F, Boonstra A, Postmus PE, van der Velden J, Vonk-Noordegraaf A, Humbert M, Eddahibi S, Guignabert C. de Man FS, et al. Among authors: perros f. Am J Respir Crit Care Med. 2012 Oct 15;186(8):780-9. doi: 10.1164/rccm.201203-0411OC. Epub 2012 Aug 2. Am J Respir Crit Care Med. 2012. PMID: 22859525 Free PMC article.
To compensate, neurohormonal systems such as the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system are up-regulated, but this may have long-term negative effects on the progression of iPAH. OBJECTIVES: Assess systemic and pulmonary RAAS activit …
To compensate, neurohormonal systems such as the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system are up-regul …