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Circulating HBV RNA and hepatitis B core-related antigen trajectories in persons with HIV/HBV coinfection and HBsAg loss on tenofovir therapy.
Begré L, Boyd A, Plissonnier ML, Testoni B, Salazar-Vizcaya L, Suter-Riniker F, Scholtès C, Béguelin C, Rockstroh JK, Günthard HF, Calmy A, Cavassini M, Hirsch HH, Schmid P, Bernasconi E, Levrero M, Wandeler G, Zoulim F, Rauch A; Swiss HIV Cohort Study. Begré L, et al. J Infect Dis. 2024 Apr 16:jiae189. doi: 10.1093/infdis/jiae189. Online ahead of print. J Infect Dis. 2024. PMID: 38626170
BACKGROUND: We evaluated long-term trajectories of circulating hepatitis B virus (HBV)-RNA and hepatitis B core-related antigen (HBcrAg) in persons with and without hepatitis B surface antigen (HBsAg) loss during tenofovir therapy in the Swiss HIV Cohort Study. ...
BACKGROUND: We evaluated long-term trajectories of circulating hepatitis B virus (HBV)-RNA and hepatitis B core-related antigen (HBcr …
Impact of Integrase Inhibitors on Cardiovascular Disease Events in People With Human Immunodeficiency Virus Starting Antiretroviral Therapy.
Surial B, Chammartin F, Damas J, Calmy A, Haerry D, Stöckle M, Schmid P, Bernasconi E, Fux CA, Tarr PE, Günthard HF, Wandeler G, Rauch A; Swiss HIV Cohort Study. Surial B, et al. Clin Infect Dis. 2023 Sep 11;77(5):729-737. doi: 10.1093/cid/ciad286. Clin Infect Dis. 2023. PMID: 37157869 Free PMC article. Clinical Trial.
CONCLUSIONS: In this target trial emulation, we found no difference in short- or long-term risk for CVD events between treatment-naive people with human immunodeficiency virus who started INSTI-based ART and those on other ART....
CONCLUSIONS: In this target trial emulation, we found no difference in short- or long-term risk for CVD events between treatment-naiv …
Sustained Effect on Hepatitis C Elimination Among Men Who Have Sex With Men in the Swiss HIV Cohort Study: A Systematic Re-Screening for Hepatitis C RNA Two Years Following a Nation-Wide Elimination Program.
Kusejko K, Salazar-Vizcaya L, Shah C, Stöckle M, Béguelin C, Schmid P, Ongaro M, Darling K, Bernasconi E, Rauch A, Kouyos RD, Günthard HF, Böni J, Fehr JS, Braun DL; Swiss HIV Cohort Study. Kusejko K, et al. Clin Infect Dis. 2022 Nov 14;75(10):1723-1731. doi: 10.1093/cid/ciac273. Clin Infect Dis. 2022. PMID: 35404384 Free article.
The trial led to a 91% and 77% decline of HCV prevalence and incidence, respectively. The long-term effect of this HCV micro-elimination program is yet to be explored. ...
The trial led to a 91% and 77% decline of HCV prevalence and incidence, respectively. The long-term effect of this HCV micro-eliminat …
Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link.
Nguyen H, Thorball CW, Fellay J, Böni J, Yerly S, Perreau M, Hirsch HH, Kusejko K, Thurnheer MC, Battegay M, Cavassini M, Kahlert CR, Bernasconi E, Günthard HF, Kouyos RD; Swiss HIV Cohort Study. Nguyen H, et al. Among authors: perreau m. Elife. 2021 Jun 1;10:e67388. doi: 10.7554/eLife.67388. Elife. 2021. PMID: 34061023 Free PMC article.
RT-E138:HLA-B18 exhibited the greatest significance in both analyses (interaction term odds ratio [OR] 1.169 [95% confidence interval (CI) 1.075-1.273]; p-value<0.001; survival hazard ratio 12.211 [95% CI 3.523-42.318]; p-value<0.001). ...
RT-E138:HLA-B18 exhibited the greatest significance in both analyses (interaction term odds ratio [OR] 1.169 [95% confidence interval …
Data linkage to evaluate the long-term risk of HIV infection in individuals seeking post-exposure prophylaxis.
Hovaguimian F, Günthard HF, Hauser C, Conen A, Bernasconi E, Calmy A, Cavassini M, Seneghini M, Marzel A, Heinrich H, Scherrer A, Riou J, Spoerri A, Schmidlin K, Balakrishna S, Braun DL, Rampini SK, Fehr JS, Kouyos RD; Swiss HIV Cohort Study. Hovaguimian F, et al. Nat Commun. 2021 Feb 22;12(1):1219. doi: 10.1038/s41467-021-21485-w. Nat Commun. 2021. PMID: 33619268 Free PMC article.
Evidence on the long-term risk of HIV infection in individuals taking HIV post-exposure prophylaxis remains limited. ...This enables us to identify 22 HIV infections and to obtain long-term follow-up data, which reveal a median of 4.1 years between consultation for …
Evidence on the long-term risk of HIV infection in individuals taking HIV post-exposure prophylaxis remains limited. ...This enables …
Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART.
Wan C, Bachmann N, Mitov V, Blanquart F, Céspedes SP, Turk T, Neumann K, Beerenwinkel N, Bogojeska J, Fellay J, Roth V, Böni J, Perreau M, Klimkait T, Yerly S, Battegay M, Walti L, Calmy A, Vernazza P, Bernasconi E, Cavassini M, Metzner KJ, Günthard HF, Kouyos RD; Swiss HIV Cohort Study. Wan C, et al. Among authors: perreau m. Nat Commun. 2020 Nov 2;11(1):5542. doi: 10.1038/s41467-020-19198-7. Nat Commun. 2020. PMID: 33139735 Free PMC article.
We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzing the distribution of those traits on viral phylogenies from both partial-pol and viral near full-length genome sequences. ...At the same time, we find more tentative evidence fo …
We investigate the heritability of the HIV-1 reservoir size and its long-term decay by analyzing the distribution of those traits on …
Host Genomics of the HIV-1 Reservoir Size and Its Decay Rate During Suppressive Antiretroviral Treatment.
Thorball CW, Borghesi A, Bachmann N, Von Siebenthal C, Vongrad V, Turk T, Neumann K, Beerenwinkel N, Bogojeska J, Roth V, Kok YL, Parbhoo S, Wieser M, Böni J, Perreau M, Klimkait T, Yerly S, Battegay M, Rauch A, Schmid P, Bernasconi E, Cavassini M, Kouyos RD, Günthard HF, Metzner KJ, Fellay J; Swiss HIV Cohort Study. Thorball CW, et al. Among authors: perreau m. J Acquir Immune Defic Syndr. 2020 Dec 1;85(4):517-524. doi: 10.1097/QAI.0000000000002473. J Acquir Immune Defic Syndr. 2020. PMID: 33136754 Free article.
CONCLUSIONS: Our results point to a limited influence of human genetics on the size of the HIV-1 reservoir and its long-term dynamics in successfully treated individuals....
CONCLUSIONS: Our results point to a limited influence of human genetics on the size of the HIV-1 reservoir and its long-term dynamics …
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure.
Vigano S, Bobisse S, Coukos G, Perreau M, Harari A. Vigano S, et al. Among authors: perreau m. Front Immunol. 2020 Jun 30;11:1350. doi: 10.3389/fimmu.2020.01350. eCollection 2020. Front Immunol. 2020. PMID: 32714330 Free PMC article. Review.
In both conditions, the immune system is persistently exposed to antigens leading to systemic inflammation, lack of generation of long-term memory and exhaustion of effector cells. This triggers a negative feedback loop where effector cells are unable to resolve the pathol …
In both conditions, the immune system is persistently exposed to antigens leading to systemic inflammation, lack of generation of long-te …
Differences in social and mental well-being of long-term survivors among people who inject drugs and other participants in the Swiss HIV Cohort Study: 1980-2018.
Kusejko K, Marzel A, Nguyen H, Chaudron SE, Bachmann N, Weber R, Bruggmann P, Roth JA, Bernasconi E, Calmy A, Cavassini M, Bregenzer A, Böni J, Yerly S, Klimkait T, Perreau M, Walti LN, Günthard HF, Kouyos RD; Swiss HIV Cohort Study. Kusejko K, et al. Among authors: perreau m. Antivir Ther. 2020;25(1):43-54. doi: 10.3851/IMP3347. Antivir Ther. 2020. PMID: 32235037
BACKGROUND: People living with HIV who were diagnosed before highly active antiretroviral therapy became available in 1996 and who survived at least 15 years after HIV diagnosis, termed long-term survivors (LTS), form a particularly vulnerable population. ...
BACKGROUND: People living with HIV who were diagnosed before highly active antiretroviral therapy became available in 1996 and who survived …
T-cell exhaustion in HIV infection.
Fenwick C, Joo V, Jacquier P, Noto A, Banga R, Perreau M, Pantaleo G. Fenwick C, et al. Among authors: perreau m. Immunol Rev. 2019 Nov;292(1):149-163. doi: 10.1111/imr.12823. Immunol Rev. 2019. PMID: 31883174 Free PMC article. Review.
In this review, we will discuss the role of T-cell exhaustion in HIV disease progression, the long-term defect of T-cell function even in aviremic patients on antiretroviral therapy (ART), the role of exhaustion-specific markers in maintaining a reservoir of latently infec …
In this review, we will discuss the role of T-cell exhaustion in HIV disease progression, the long-term defect of T-cell function eve …
17 results