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Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome.
Sievänen T, Törmäkangas T, Laakkonen EK, Mecklin JP, Pylvänäinen K, Seppälä TT, Peltomäki P, Sipilä S, Sillanpää E. Sievänen T, et al. Among authors: peltomaki p. Cancers (Basel). 2021 Apr 13;13(8):1849. doi: 10.3390/cancers13081849. Cancers (Basel). 2021. PMID: 33924417 Free PMC article.
Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased ris …
Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term …
Mlh1 deficiency in normal mouse colon mucosa associates with chromosomally unstable colon cancer.
Pussila M, Törönen P, Einarsdottir E, Katayama S, Krjutškov K, Holm L, Kere J, Peltomäki P, Mäkinen MJ, Linden J, Nyström M. Pussila M, et al. Among authors: peltomaki p. Carcinogenesis. 2018 May 28;39(6):788-797. doi: 10.1093/carcin/bgy056. Carcinogenesis. 2018. PMID: 29701748 Free PMC article.
Our study was designed to comprehensively follow genome-wide expression changes and their implications during colon tumorigenesis. We conducted a long-term feeding experiment in the mouse to address expression changes arising in histologically normal colonic mucosa as puta …
Our study was designed to comprehensively follow genome-wide expression changes and their implications during colon tumorigenesis. We conduc …
Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice.
Pussila M, Sarantaus L, Dermadi Bebek D, Valo S, Reyhani N, Ollila S, Päivärinta E, Peltomäki P, Mutanen M, Nyström M. Pussila M, et al. Among authors: peltomaki p. PLoS One. 2013 Oct 8;8(10):e76865. doi: 10.1371/journal.pone.0076865. eCollection 2013. PLoS One. 2013. PMID: 24204690 Free PMC article.
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths in the Western world and interactions between genetic and environmental factors, including diet, are suggested to play a critical role in its etiology. We conducted a long-term feeding experim …
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths in the Western world and interactions between genetic and e …
Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study.
Aktan-Collan K, Kääriäinen H, Järvinen H, Peltomäki P, Pylvänäinen K, Mecklin JP, Haukkala A. Aktan-Collan K, et al. Among authors: peltomaki p. Fam Cancer. 2013 Dec;12(4):639-46. doi: 10.1007/s10689-013-9628-9. Fam Cancer. 2013. PMID: 23512527
We evaluated long-term psychosocial consequences of predictive genetic testing, and surveillance behaviour in Lynch syndrome (LS). ...
We evaluated long-term psychosocial consequences of predictive genetic testing, and surveillance behaviour in Lynch syndrome (LS). .. …
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.
Järvinen HJ, Renkonen-Sinisalo L, Aktán-Collán K, Peltomäki P, Aaltonen LA, Mecklin JP. Järvinen HJ, et al. Among authors: peltomaki p. J Clin Oncol. 2009 Oct 1;27(28):4793-7. doi: 10.1200/JCO.2009.23.7784. Epub 2009 Aug 31. J Clin Oncol. 2009. PMID: 19720893
PURPOSE: Colonoscopies with polypectomies and endometrial biopsies with transvaginal ultrasonography, repeated at 2- to 3-year intervals, are performed for prevention or early detection of cancer in patients with DNA mismatch repair gene mutation causing Lynch syndrome. The long- …
PURPOSE: Colonoscopies with polypectomies and endometrial biopsies with transvaginal ultrasonography, repeated at 2- to 3-year intervals, ar …
Lynch syndrome and related familial colorectal cancers.
Abdel-Rahman WM, Peltomäki P. Abdel-Rahman WM, et al. Among authors: peltomaki p. Crit Rev Oncog. 2008;14(1):1-22; discussion 23-31. doi: 10.1615/critrevoncog.v14.i1.10. Crit Rev Oncog. 2008. PMID: 19105568 Review.
Amsterdam I and II criteria for clinical diagnosis and Bethesda guidelines for molecular testing of suspected patients usually point out additional families in which there is no evidence of mismatch repair deficiency even after screening by microsatellite instability analysis and …
Amsterdam I and II criteria for clinical diagnosis and Bethesda guidelines for molecular testing of suspected patients usually point out add …
Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction.
Aktan-Collan K, Mecklin JP, Järvinen H, Nyström-Lahti M, Peltomäki P, Söderling I, Uutela A, de la Chapelle A, Kääriäinen H. Aktan-Collan K, et al. Among authors: peltomaki p. Int J Cancer. 2000 Jan 20;89(1):44-50. Int J Cancer. 2000. PMID: 10719730 Free article.
The aim of this prospective study was to assess the uptake of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC) and its associations with sociodemographic and other factors, and long-term satisfaction with taking the test. The test was offer …
The aim of this prospective study was to assess the uptake of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNP …
Pallister-Killian syndrome: cytogenetic and molecular studies.
Peltomäki P, Knuutila S, Ritvanen A, Kaitila I, de la Chapelle A. Peltomäki P, et al. Clin Genet. 1987 Jun;31(6):399-405. doi: 10.1111/j.1399-0004.1987.tb02832.x. Clin Genet. 1987. PMID: 2887316
A new feature which may be important in understanding the mechanism of origin of the abnormality is described: the proportion of abnormal mitoses falls dramatically during long-term culture of fibroblasts....
A new feature which may be important in understanding the mechanism of origin of the abnormality is described: the proportion of abnormal mi …