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The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism.
Pesce E, Sondo E, Ferrera L, Tomati V, Caci E, Scudieri P, Musante I, Renda M, Baatallah N, Servel N, Hinzpeter A, di Bernardo D, Pedemonte N, Galietta LJV. Pesce E, et al. Among authors: pedemonte n. Front Pharmacol. 2018 Dec 13;9:1464. doi: 10.3389/fphar.2018.01464. eCollection 2018. Front Pharmacol. 2018. PMID: 30618756 Free PMC article.
We tested the effect of spautin-1 on F508del-CFTR since it is an inhibitor of USP10 deubiquitinase and of autophagy, a target and a biological process that have been associated with cystic fibrosis and mutant CFTR. We found that short-term treatment of cells with spautin-1 …
We tested the effect of spautin-1 on F508del-CFTR since it is an inhibitor of USP10 deubiquitinase and of autophagy, a target and a biologic …
Large expert-curated database for benchmarking document similarity detection in biomedical literature search.
Brown P; RELISH Consortium; Zhou Y. Brown P, et al. Database (Oxford). 2019 Jan 1;2019:baz085. doi: 10.1093/database/baz085. Database (Oxford). 2019. PMID: 33326193 Free PMC article.
We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. ...
We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, …
Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia.
Sondo E, Falchi F, Caci E, Ferrera L, Giacomini E, Pesce E, Tomati V, Mandrup Bertozzi S, Goldoni L, Armirotti A, Ravazzolo R, Cavalli A, Pedemonte N. Sondo E, et al. Among authors: pedemonte n. Cell Chem Biol. 2018 Jul 19;25(7):891-905.e8. doi: 10.1016/j.chembiol.2018.04.010. Epub 2018 May 10. Cell Chem Biol. 2018. PMID: 29754957 Free article.
In immortalized and primary bronchial epithelial cells derived from CF patients homozygous for the F508del mutation, long-term incubation with inh-02 caused significant F508del-CFTR rescue. ...
In immortalized and primary bronchial epithelial cells derived from CF patients homozygous for the F508del mutation, long-term incuba …