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Exposure to PCB126 during the nursing period reversibly impacts early-life glucose tolerance.
Rice BB, Sammons KW, Ngo Tenlep SY, Weltzer MT, Reynolds LJ, Rashid CS, Swanson HI, Pearson KJ. Rice BB, et al. Among authors: pearson kj. Front Endocrinol (Lausanne). 2023 Mar 22;14:1085958. doi: 10.3389/fendo.2023.1085958. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37033268 Free PMC article.
Our current study demonstrates that exposure to PCB126 through the mother's milk does not affect short- or long-term body composition but impairs glucose tolerance in the short-term....
Our current study demonstrates that exposure to PCB126 through the mother's milk does not affect short- or long-term body composition …
Lack of Offspring Nrf2 Does Not Exacerbate the Detrimental Metabolic Outcomes Caused by In Utero PCB126 Exposure.
Rice BB, Ngo Tenlep SY, Tolaymat O, Alvi AT, Slone FR, Crosby CL, Howard SS, Hermanns CL, Montessorie NP, Swanson HI, Pearson KJ. Rice BB, et al. Among authors: pearson kj. Front Endocrinol (Lausanne). 2021 Dec 16;12:777831. doi: 10.3389/fendo.2021.777831. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34975753 Free PMC article.
We hypothesized that offspring lacking Nrf2 expression would be more susceptible to the long-term health detriments associated with perinatal PCB exposure. During gestation, whole-body Nrf2 heterozygous (Het) and whole-body Nrf2 knockout (KO) mice were exposed to vehicle o …
We hypothesized that offspring lacking Nrf2 expression would be more susceptible to the long-term health detriments associated with p …
Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.
Bernier M, Wahl D, Ali A, Allard J, Faulkner S, Wnorowski A, Sanghvi M, Moaddel R, Alfaras I, Mattison JA, Tarantini S, Tucsek Z, Ungvari Z, Csiszar A, Pearson KJ, de Cabo R. Bernier M, et al. Among authors: pearson kj. Aging (Albany NY). 2016 May;8(5):899-916. doi: 10.18632/aging.100942. Aging (Albany NY). 2016. PMID: 27070252 Free PMC article.
Previous studies have shown positive effects of long-term resveratrol (RSV) supplementation in preventing pancreatic beta cell dysfunction, arterial stiffening and metabolic decline induced by high-fat/high-sugar (HFS) diet in nonhuman primates. ...The decreased expression …
Previous studies have shown positive effects of long-term resveratrol (RSV) supplementation in preventing pancreatic beta cell dysfun …
Exercise Improves Glucose Disposal and Insulin Signaling in Pregnant Mice Fed a High Fat Diet.
Carter LG, Ngo Tenlep SY, Woollett LA, Pearson KJ. Carter LG, et al. Among authors: pearson kj. J Diabetes Metab. 2015 Dec;6(12):634. doi: 10.4172/2155-156.1000634. Epub 2015 Dec 30. J Diabetes Metab. 2015. PMID: 26966635 Free PMC article.
CONCLUSION: The use of voluntary exercise improves glucose homeostasis and body composition in pregnant female mice. Thus, future studies could investigate potential long-term health benefits in offspring born to obese exercising dams....
CONCLUSION: The use of voluntary exercise improves glucose homeostasis and body composition in pregnant female mice. Thus, future studies co …
Adult offspring of high-fat diet-fed dams can have normal glucose tolerance and body composition.
Platt KM, Charnigo RJ, Pearson KJ. Platt KM, et al. Among authors: pearson kj. J Dev Orig Health Dis. 2014 Jun;5(3):229-39. doi: 10.1017/S2040174414000154. J Dev Orig Health Dis. 2014. PMID: 24901663 Free PMC article.
Maternal high-fat diet consumption and obesity have been shown to program long-term obesity and lead to impaired glucose tolerance in offspring. ...The body weight of pups born to 45% lard-fed dams was significantly increased before weaning, but only female offspring born …
Maternal high-fat diet consumption and obesity have been shown to program long-term obesity and lead to impaired glucose tolerance in …
Maternal exercise improves insulin sensitivity in mature rat offspring.
Carter LG, Qi NR, De Cabo R, Pearson KJ. Carter LG, et al. Among authors: pearson kj. Med Sci Sports Exerc. 2013 May;45(5):832-40. doi: 10.1249/MSS.0b013e31827de953. Med Sci Sports Exerc. 2013. PMID: 23247711 Free PMC article.
PURPOSE: Recent findings have shown that the intrauterine environment can negatively influence long-term insulin sensitivity in the offspring. Here we look at maternal voluntary exercise as an intervention to improve offspring insulin sensitivity and glucose homeostasis. . …
PURPOSE: Recent findings have shown that the intrauterine environment can negatively influence long-term insulin sensitivity in the o …
Perinatal exercise improves glucose homeostasis in adult offspring.
Carter LG, Lewis KN, Wilkerson DC, Tobia CM, Ngo Tenlep SY, Shridas P, Garcia-Cazarin ML, Wolff G, Andrade FH, Charnigo RJ, Esser KA, Egan JM, de Cabo R, Pearson KJ. Carter LG, et al. Among authors: pearson kj. Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1061-8. doi: 10.1152/ajpendo.00213.2012. Epub 2012 Aug 28. Am J Physiol Endocrinol Metab. 2012. PMID: 22932781 Free PMC article.
Emerging research has shown that subtle factors during pregnancy and gestation can influence long-term health in offspring. In an attempt to be proactive, we set out to explore whether a nonpharmacological intervention, perinatal exercise, might improve offspring health. . …
Emerging research has shown that subtle factors during pregnancy and gestation can influence long-term health in offspring. In an att …
SRT1720 improves survival and healthspan of obese mice.
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. Minor RK, et al. Among authors: pearson kj. Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Sci Rep. 2011. PMID: 22355589 Free PMC article.
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1alpha-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibili …
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC- …