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A high CMV-specific T cell response associates with SARS-CoV-2-specific IL-17 T cell production.
Frozza FTB, Fazolo T, de Souza PO, Lima K, da Fontoura JC, Borba TS, Polese-Bonatto M, Kern LB, Stein RT, Pawelec G, Bonorino C. Frozza FTB, et al. Among authors: pawelec g. Med Microbiol Immunol. 2023 Feb;212(1):75-91. doi: 10.1007/s00430-022-00758-1. Epub 2022 Dec 13. Med Microbiol Immunol. 2023. PMID: 36512097 Free PMC article.
Human cytomegalovirus (CMV) is a widespread persistent herpes virus requiring lifelong immune surveillance to maintain latency. Such long-term interactions with the immune system may be associated with deleterious effects including immune exhaustion and senescence. ...
Human cytomegalovirus (CMV) is a widespread persistent herpes virus requiring lifelong immune surveillance to maintain latency. Such long- …
Human CD4+ T-Cell Clone Expansion Leads to the Expression of the Cysteine Peptidase Inhibitor Cystatin F.
Perišić Nanut M, Pawelec G, Kos J. Perišić Nanut M, et al. Among authors: pawelec g. Int J Mol Sci. 2021 Aug 5;22(16):8408. doi: 10.3390/ijms22168408. Int J Mol Sci. 2021. PMID: 34445118 Free PMC article.
CD4+ CTLs utilize the fundamental cytotoxic effector mechanisms also utilized by CD8+ CTLs and natural killer cells. During long-term cultivation, CD4+ T cells were also shown to acquire cytotoxic functions. ...
CD4+ CTLs utilize the fundamental cytotoxic effector mechanisms also utilized by CD8+ CTLs and natural killer cells. During long-term …
The conundrum of human immune system "senescence".
Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA. Pawelec G, et al. Mech Ageing Dev. 2020 Dec;192:111357. doi: 10.1016/j.mad.2020.111357. Epub 2020 Sep 17. Mech Ageing Dev. 2020. PMID: 32949594 Free PMC article. Review.
Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referred to as "immunosenescence". But what exactly is meant by this term? It has been used loosely in the literature, resulting in a certa …
Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referr …
Influenza Vaccination: Accelerating the Process for New Vaccine Development in Older Adults.
McElhaney JE, Andrew MK, Haynes L, Kuchel GA, McNeil SA, Pawelec G. McElhaney JE, et al. Among authors: pawelec g. Interdiscip Top Gerontol Geriatr. 2020;43:98-112. doi: 10.1159/000504478. Epub 2020 Apr 9. Interdiscip Top Gerontol Geriatr. 2020. PMID: 32305974 Review.
Common chronic conditions not only contribute to the loss of immune protection after vaccination and increase the risk for serious outcomes of influenza, but also increase the long-term consequences following hospitalization. Interactions of T and B cell ageing, chronic el …
Common chronic conditions not only contribute to the loss of immune protection after vaccination and increase the risk for serious outcomes …
Influenza Vaccination in Older Adults: Recent Innovations and Practical Applications.
Andrew MK, Bowles SK, Pawelec G, Haynes L, Kuchel GA, McNeil SA, McElhaney JE. Andrew MK, et al. Among authors: pawelec g. Drugs Aging. 2019 Jan;36(1):29-37. doi: 10.1007/s40266-018-0597-4. Drugs Aging. 2019. PMID: 30411283 Review.
Influenza can lead to serious illness, particularly for older adults. In addition to short-term morbidity and mortality during the acute infection, recovery can be prolonged and often incomplete. ...
Influenza can lead to serious illness, particularly for older adults. In addition to short-term morbidity and mortality during the ac …
Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells.
Janssen N, Speigl L, Pawelec G, Niessner H, Shipp C. Janssen N, et al. Among authors: pawelec g. Cell Immunol. 2018 May;327:68-76. doi: 10.1016/j.cellimm.2018.02.012. Epub 2018 Feb 21. Cell Immunol. 2018. PMID: 29478948
Despite encouraging results with immunotherapeutic approaches, long-term survival is still poor. This is likely partly due to tumour-induced immune suppression mediated by myeloid-derived suppressor cells (MDSCs), which were shown to be associated with response to therapy …
Despite encouraging results with immunotherapeutic approaches, long-term survival is still poor. This is likely partly due to tumour- …
Age and immunity: What is "immunosenescence"?
Pawelec G. Pawelec G. Exp Gerontol. 2018 May;105:4-9. doi: 10.1016/j.exger.2017.10.024. Epub 2017 Oct 27. Exp Gerontol. 2018. PMID: 29111233 Review.
It may therefore be appropriate to reconsider our basic knowledge at this juncture, asking exactly what do we mean by the term "immunosenescence"? This is attempted in this contribution to the Special Issue....
It may therefore be appropriate to reconsider our basic knowledge at this juncture, asking exactly what do we mean by the term "immun …
Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis.
Weide B, Zelba H, Derhovanessian E, Pflugfelder A, Eigentler TK, Di Giacomo AM, Maio M, Aarntzen EH, de Vries IJ, Sucker A, Schadendorf D, Büttner P, Garbe C, Pawelec G. Weide B, et al. Among authors: pawelec g. J Clin Oncol. 2012 May 20;30(15):1835-41. doi: 10.1200/JCO.2011.40.2271. Epub 2012 Apr 23. J Clin Oncol. 2012. PMID: 22529253
PATIENTS AND METHODS: We examined 84 patients with follow-up after analysis (cohort A), 18 long-term survivors with an extraordinarily favorable course of disease before analysis (> 24 months survival after first occurrence of distant metastases; cohort B), and 14 healt …
PATIENTS AND METHODS: We examined 84 patients with follow-up after analysis (cohort A), 18 long-term survivors with an extraordinaril …
Role of CMV in immune senescence.
Pawelec G, Derhovanessian E. Pawelec G, et al. Virus Res. 2011 May;157(2):175-9. doi: 10.1016/j.virusres.2010.09.010. Epub 2010 Oct 1. Virus Res. 2011. PMID: 20869407 Review.
"Immune senescence" is a descriptive term for the deleterious age-associated changes to immunity observed in all mammals studied so far. ...
"Immune senescence" is a descriptive term for the deleterious age-associated changes to immunity observed in all mammals studied so f …
High response rate after intratumoral treatment with interleukin-2: results from a phase 2 study in 51 patients with metastasized melanoma.
Weide B, Derhovanessian E, Pflugfelder A, Eigentler TK, Radny P, Zelba H, Pföhler C, Pawelec G, Garbe C. Weide B, et al. Among authors: pawelec g. Cancer. 2010 Sep 1;116(17):4139-46. doi: 10.1002/cncr.25156. Cancer. 2010. PMID: 20564107 Free article. Clinical Trial.
BACKGROUND: Systemic high-dose interleukin-2 (IL-2) achieved long-term survival in a subset of patients with advanced melanoma. The authors reported previously that intratumorally applied IL-2 induced complete local responses of all metastases in >60% of patients. ...
BACKGROUND: Systemic high-dose interleukin-2 (IL-2) achieved long-term survival in a subset of patients with advanced melanoma. The a …
31 results