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Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets.
Tran DT, Pottekat A, Lee K, Raghunathan M, Loguercio S, Mir SA, Paton AW, Paton JC, Arvan P, Kaufman RJ, Itkin-Ansari P. Tran DT, et al. Among authors: paton jc. J Clin Endocrinol Metab. 2022 Nov 23;107(11):3100-3110. doi: 10.1210/clinem/dgac493. J Clin Endocrinol Metab. 2022. PMID: 36017587 Free PMC article.
CONCLUSION: Together, the data shed new light on mechanisms by which diabetes-associated cytokines dysregulate beta-cell function. For the first time, we show that even short-term exposure to an inflammatory environment reshapes proinsulin interactions with critical chaper …
CONCLUSION: Together, the data shed new light on mechanisms by which diabetes-associated cytokines dysregulate beta-cell function. For the f …
A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid.
Shearer HL, Pace PE, Paton JC, Hampton MB, Dickerhof N. Shearer HL, et al. Among authors: paton jc. J Biol Chem. 2022 Sep;298(9):102359. doi: 10.1016/j.jbc.2022.102359. Epub 2022 Aug 9. J Biol Chem. 2022. PMID: 35952759 Free PMC article.
Here, we report the discovery of a previously uncharacterized flavoprotein disulfide reductase with HOSCN reductase activity, which we term Har (hypothiocyanous acid reductase), in Streptococcus pneumoniae, a bacterium previously found to be tolerant of HOSCN. ...
Here, we report the discovery of a previously uncharacterized flavoprotein disulfide reductase with HOSCN reductase activity, which we te …
Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain.
Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin AF, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A. Naito-Matsui Y, et al. Among authors: paton jc. J Biol Chem. 2017 Feb 17;292(7):2557-2570. doi: 10.1074/jbc.M116.768531. Epub 2017 Jan 3. J Biol Chem. 2017. PMID: 28049733 Free PMC article.
However, physiological exploration of the reasons for this long term evolutionary selection has been lacking. To explore the consequences of forced expression of Neu5Gc in the brain, we have established brain-specific Cmah transgenic mice. ...
However, physiological exploration of the reasons for this long term evolutionary selection has been lacking. To explore the conseque …
EcxAB is a founding member of a new family of metalloprotease AB5 toxins with a hybrid cholera-like B subunit.
Ng NM, Littler DR, Paton AW, Le Nours J, Rossjohn J, Paton JC, Beddoe T. Ng NM, et al. Among authors: paton jc. Structure. 2013 Nov 5;21(11):2003-13. doi: 10.1016/j.str.2013.08.024. Epub 2013 Oct 3. Structure. 2013. PMID: 24095060 Free article.
Furthermore, EcxA is distinct from previously characterized proteases and thus founds an AB5-associated metzincin family that we term the toxilysins. EcxAB provides the first observation of conserved B subunit usage across different AB5 toxin families and provides evidence …
Furthermore, EcxA is distinct from previously characterized proteases and thus founds an AB5-associated metzincin family that we term …
c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection.
Ogunniyi AD, Paton JC, Kirby AC, McCullers JA, Cook J, Hyodo M, Hayakawa Y, Karaolis DK. Ogunniyi AD, et al. Among authors: paton jc. Vaccine. 2008 Aug 26;26(36):4676-85. doi: 10.1016/j.vaccine.2008.06.099. Epub 2008 Jul 18. Vaccine. 2008. PMID: 18640167 Free PMC article.
The effects of intranasal pretreatment with c-di-GMP, or intraperitoneal coadministration of c-di-GMP with the pneumolysin toxoid (PdB) or pneumococcal surface protein A (PspA) before pneumococcal challenge, were investigated in mice. We found that c-di-GMP had no significant dir …
The effects of intranasal pretreatment with c-di-GMP, or intraperitoneal coadministration of c-di-GMP with the pneumolysin toxoid (PdB) or p …
Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae.
Coffey TJ, Enright MC, Daniels M, Morona JK, Morona R, Hryniewicz W, Paton JC, Spratt BG. Coffey TJ, et al. Among authors: paton jc. Mol Microbiol. 1998 Jan;27(1):73-83. doi: 10.1046/j.1365-2958.1998.00658.x. Mol Microbiol. 1998. PMID: 9466257 Free article.
Changes in capsular type by recombination may therefore be relatively frequent in pneumococci and this has implications for the long-term efficacy of conjugate pneumococcal vaccines that will protect against only a limited number of serotypes....
Changes in capsular type by recombination may therefore be relatively frequent in pneumococci and this has implications for the long-term …