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Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury.
Lan S, Yang B, Migneault F, Turgeon J, Bourgault M, Dieudé M, Cardinal H, Hickey MJ, Patey N, Hébert MJ. Lan S, et al. Among authors: patey n. Am J Physiol Renal Physiol. 2021 Sep 1;321(3):F335-F351. doi: 10.1152/ajprenal.00690.2020. Epub 2021 Aug 2. Am J Physiol Renal Physiol. 2021. PMID: 34338031 Free article.
Caspase-3(-/-) mice with severe IRI also showed better preservation of long-term renal function. Intravital imaging and microcomputed tomography revealed preserved PTC permeability and better terminal capillary density in caspase-3(-/-) mice. Collectively, these results de …
Caspase-3(-/-) mice with severe IRI also showed better preservation of long-term renal function. Intravital imaging and microcomputed …
Acute Kidney Injury, Microvascular Rarefaction, and Estimated Glomerular Filtration Rate in Kidney Transplant Recipients.
Doreille A, Azzi F, Larivière-Beaudoin S, Karakeussian-Rimbaud A, Trudel D, Hébert MJ, Dieudé M, Patey N, Cardinal H. Doreille A, et al. Among authors: patey n. Clin J Am Soc Nephrol. 2021 Mar 8;16(3):415-426. doi: 10.2215/CJN.07270520. Clin J Am Soc Nephrol. 2021. PMID: 33648972 Free PMC article.
Here, we assessed whether delayed graft function is associated with peritubular capillary loss and evaluated the association between this loss and long-term kidney graft function. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This observational, retrospective cohort s …
Here, we assessed whether delayed graft function is associated with peritubular capillary loss and evaluated the association between this lo …
Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury.
Yang B, Lan S, Dieudé M, Sabo-Vatasescu JP, Karakeussian-Rimbaud A, Turgeon J, Qi S, Gunaratnam L, Patey N, Hébert MJ. Yang B, et al. Among authors: patey n. J Am Soc Nephrol. 2018 Jul;29(7):1900-1916. doi: 10.1681/ASN.2017050581. Epub 2018 Jun 20. J Am Soc Nephrol. 2018. PMID: 29925521 Free PMC article.
In contrast, caspase-3(-/-) mice had less microvascular congestion and activation in the early and extension phases of AKI. In the long term (3 weeks after IRI), caspase-3(-/-) mice had reduced microvascular rarefaction and renal fibrosis, as well as decreased expression o …
In contrast, caspase-3(-/-) mice had less microvascular congestion and activation in the early and extension phases of AKI. In the long t …
Apple peel polyphenols reduce mitochondrial dysfunction in mice with DSS-induced ulcerative colitis.
Yeganeh PR, Leahy J, Spahis S, Patey N, Desjardins Y, Roy D, Delvin E, Garofalo C, Leduc-Gaudet JP, St-Pierre D, Beaulieu JF, Marette A, Gouspillou G, Levy E. Yeganeh PR, et al. Among authors: patey n. J Nutr Biochem. 2018 Jul;57:56-66. doi: 10.1016/j.jnutbio.2018.03.008. Epub 2018 Mar 21. J Nutr Biochem. 2018. PMID: 29674247
Inflammatory bowel diseases (IBDs) are multifaceted and relapsing immune disorders, which necessitate long-term dependence on powerful drugs. As the use of natural product-based therapies has emerged as a promising intervention, the present study aimed to further character …
Inflammatory bowel diseases (IBDs) are multifaceted and relapsing immune disorders, which necessitate long-term dependence on powerfu …
Anti-LG3 Antibodies Aggravate Renal Ischemia-Reperfusion Injury and Long-Term Renal Allograft Dysfunction.
Yang B, Dieudé M, Hamelin K, Hénault-Rondeau M, Patey N, Turgeon J, Lan S, Pomerleau L, Quesnel M, Peng J, Tremblay J, Shi Y, Chan JS, Hébert MJ, Cardinal H. Yang B, et al. Among authors: patey n. Am J Transplant. 2016 Dec;16(12):3416-3429. doi: 10.1111/ajt.13866. Epub 2016 Jun 23. Am J Transplant. 2016. PMID: 27172087 Free article.
These results provide novel insights into the pathways that modulate the severity of renal injury at the time of transplantation and their impact on long-term outcomes....
These results provide novel insights into the pathways that modulate the severity of renal injury at the time of transplantation and their i …
Can Monitoring Fetal Intestinal Inflammation Using Heart Rate Variability Analysis Signal Incipient Necrotizing Enterocolitis of the Neonate?
Liu HL, Garzoni L, Herry C, Durosier LD, Cao M, Burns P, Fecteau G, Desrochers A, Patey N, Seely AJ, Faure C, Frasch MG. Liu HL, et al. Among authors: patey n. Pediatr Crit Care Med. 2016 Apr;17(4):e165-76. doi: 10.1097/PCC.0000000000000643. Pediatr Crit Care Med. 2016. PMID: 26914621
SETTING: University research laboratory. SUBJECTS: Chronically instrumented near-term fetal sheep (n = 21). MEASUREMENTS AND MAIN RESULTS: Animals were surgically instrumented with vascular catheters and electrocardiogram to allow manipulation and recording from nonanesthe …
SETTING: University research laboratory. SUBJECTS: Chronically instrumented near-term fetal sheep (n = 21). MEASUREMENTS AND MAIN RES …
Anti-CD20 treatment of giant cell hepatitis with autoimmune hemolytic anemia.
Paganelli M, Patey N, Bass LM, Alvarez F. Paganelli M, et al. Among authors: patey n. Pediatrics. 2014 Oct;134(4):e1206-10. doi: 10.1542/peds.2014-0032. Epub 2014 Sep 8. Pediatrics. 2014. PMID: 25201797
Early treatment could reduce the use of corticosteroids. Nevertheless, short-term steroids should be initially associated with rituximab to account for autoantibodies' half-life. ...
Early treatment could reduce the use of corticosteroids. Nevertheless, short-term steroids should be initially associated with rituxi …
Exome sequencing identifies mutations in the gene TTC7A in French-Canadian cases with hereditary multiple intestinal atresia.
Samuels ME, Majewski J, Alirezaie N, Fernandez I, Casals F, Patey N, Decaluwe H, Gosselin I, Haddad E, Hodgkinson A, Idaghdour Y, Marchand V, Michaud JL, Rodrigue MA, Desjardins S, Dubois S, Le Deist F, Awadalla P, Raymond V, Maranda B. Samuels ME, et al. Among authors: patey n. J Med Genet. 2013 May;50(5):324-9. doi: 10.1136/jmedgenet-2012-101483. Epub 2013 Feb 19. J Med Genet. 2013. PMID: 23423984 Free PMC article.
Surgical interventions are palliative but do not provide long-term survival. Severe immunodeficiency may be associated with the phenotype. ...
Surgical interventions are palliative but do not provide long-term survival. Severe immunodeficiency may be associated with the pheno …
Tissue accumulation of lanthanum as compared to aluminum in rats with chronic renal failure--possible harmful effects after long-term exposure.
Nikolov IG, Joki N, Vicca S, Patey N, Auchère D, Benchitrit J, Flinois JP, Ziol M, Beaune P, Drüeke TB, Lacour B. Nikolov IG, et al. Among authors: patey n. Nephron Exp Nephrol. 2010;115(4):e112-21. doi: 10.1159/000313492. Epub 2010 Apr 28. Nephron Exp Nephrol. 2010. PMID: 20424489
Hepatic total cytochrome p450 content was reduced in CRF La, but not in CRF Al rats. CONCLUSION: Long-term oral La overload in rats with CRF was associated with a decrease in liver (and total body) weight and mild alterations of liver function, as was Al overload, possibly …
Hepatic total cytochrome p450 content was reduced in CRF La, but not in CRF Al rats. CONCLUSION: Long-term oral La overload in rats w …
High-dosage intravenous immunoglobulin-associated macrovacuoles are associated with chronic tubulointerstitial lesion worsening in renal transplant recipients.
Bollée G, Anglicheau D, Loupy A, Zuber J, Patey N, Mac Gregor D, Martinez F, Mamzer-Bruneel MF, Snanoudj R, Thervet E, Legendre C, Noël LH. Bollée G, et al. Among authors: patey n. Clin J Am Soc Nephrol. 2008 Sep;3(5):1461-8. doi: 10.2215/CJN.00500108. Epub 2008 Jun 4. Clin J Am Soc Nephrol. 2008. PMID: 18525007 Free PMC article.
These data suggest a deleterious impact of IVIg-induced macrovacuoles on chronic tubulointerstitial changes and long-term renal function....
These data suggest a deleterious impact of IVIg-induced macrovacuoles on chronic tubulointerstitial changes and long-term renal funct …
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