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Asymptomatic neonatal herpes simplex virus infection in mice leads to long-term cognitive impairment.
Dutton A, Patel CD, Taylor SA, Garland CR, Turnbaugh EM, Alers-Velazquez R, Mehrbach J, Nautiyal KM, Leib DA. Dutton A, et al. Among authors: patel cd. bioRxiv [Preprint]. 2024 Apr 22:2024.04.22.590596. doi: 10.1101/2024.04.22.590596. bioRxiv. 2024. PMID: 38712140 Free PMC article. Preprint.
Given the ubiquitous nature of HSV infection and frequency of asymptomatic shedding in adults, subclinical infections are underreported, yet could contribute to long-term neurological damage. To assess potential neurological morbidity associated with subclinical nHSV infec …
Given the ubiquitous nature of HSV infection and frequency of asymptomatic shedding in adults, subclinical infections are underreported, yet …
GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes.
Uenishi GI, Repic M, Yam JY, Landuyt A, Saikumar-Lakshmi P, Guo T, Zarin P, Sassone-Corsi M, Chicoine A, Kellogg H, Hunt M, Drow T, Tewari R, Cook PJ, Yang SJ, Cerosaletti K, Schweinoch D, Guiastrennec B, James E, Patel C, Chen TF, Buckner JH, Rawlings DJ, Wickham TJ, Mueller KT. Uenishi GI, et al. Among authors: patel c. JCI Insight. 2024 Feb 8;9(6):e171844. doi: 10.1172/jci.insight.171844. JCI Insight. 2024. PMID: 38516892 Free PMC article.
Tregs have the potential to establish long-term immune tolerance in patients recently diagnosed with type 1 diabetes (T1D) by preserving beta cell function. ...
Tregs have the potential to establish long-term immune tolerance in patients recently diagnosed with type 1 diabetes (T1D) by preserv …
Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).
Chung MK, House JS, Akhtari FS, Makris KC, Langston MA, Islam KT, Holmes P, Chadeau-Hyam M, Smirnov AI, Du X, Thessen AE, Cui Y, Zhang K, Manrai AK, Motsinger-Reif A, Patel CJ; Members of the Exposomics Consortium. Chung MK, et al. Among authors: patel cj. Exposome. 2024 Jan 17;4(1):osae001. doi: 10.1093/exposome/osae001. eCollection 2024. Exposome. 2024. PMID: 38344436 Free PMC article.
Here, we introduce the exposome-wide association study (ExWAS), an approach designed for systematic discovery of relationships between phenotypes and various exposures, identifying significant associations while controlling for multiple comparisons. We advocate for the standardiz …
Here, we introduce the exposome-wide association study (ExWAS), an approach designed for systematic discovery of relationships between pheno …
Pulmonary vein narrowing after pulsed field versus thermal ablation.
Mansour M, Gerstenfeld EP, Patel C, Natale A, Whang W, Cuoco FA, Mountantonakis SE, Gibson DN, Harding JD, Holland SK, Achyutha AB, Schneider CW, Mugglin AS, Albrecht EM, Stein KM, Lehmann JW, Reddy VY. Mansour M, et al. Among authors: patel c. Europace. 2024 Feb 1;26(2):euae038. doi: 10.1093/europace/euae038. Europace. 2024. PMID: 38305503 Free PMC article. Clinical Trial.
AIMS: When it occurs, pulmonary vein (PV) stenosis after atrial fibrillation (AF) ablation is associated with significant morbidity. Even mild-to-moderate PV narrowing may have long-term implications. Unlike thermal ablation energies, such as radiofrequency (RF) or cryothe …
AIMS: When it occurs, pulmonary vein (PV) stenosis after atrial fibrillation (AF) ablation is associated with significant morbidity. Even mi …
Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE; GRADE Research Group. Rasouli N, et al. Diabetes Care. 2024 Apr 1;47(4):580-588. doi: 10.2337/dc23-1070. Diabetes Care. 2024. PMID: 38211595 Clinical Trial.
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity and beta-cell function. ...After adjustment for HOMA2-%S to obtain an estimate of …
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and si …
Impact of Insulin Sensitivity and β-Cell Function Over Time on Glycemic Outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): Differential Treatment Effects of Dual Therapy.
Utzschneider KM, Younes N, Butera NM, Balasubramanyam A, Bergenstal RM, Barzilay J, DeSouza C, DeFronzo RA, Elasy T, Krakoff J, Kahn SE, Rasouli N, Valencia WM, Sivitz WI; GRADE Research Group. Utzschneider KM, et al. Diabetes Care. 2024 Apr 1;47(4):571-579. doi: 10.2337/dc23-1059. Diabetes Care. 2024. PMID: 38190619 Clinical Trial.
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in the sitagliptin group on initial (short-term) HbA1c response in comparison with the glimepiride and liraglutide groups....
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in …
TSC2 S1365A mutation potently regulates CD8+ T cell function and differentiation and improves adoptive cellular cancer therapy.
Patel CH, Dong Y, Koleini N, Wang X, Dunkerly-Eyring BL, Wen J, Ranek MJ, Bartle LM, Henderson DB, Sagert J, Kass DA, Powell JD. Patel CH, et al. JCI Insight. 2023 Nov 8;8(21):e167829. doi: 10.1172/jci.insight.167829. JCI Insight. 2023. PMID: 37788104 Free PMC article.
The TSC2-SA mutation enhanced both T cell effector function and long-term persistence/memory formation, supporting an approach to engineer better CAR-T cells for treating cancer....
The TSC2-SA mutation enhanced both T cell effector function and long-term persistence/memory formation, supporting an approach to eng …
Validation of a Deep Learning Algorithm for Continuous, Real-Time Detection of Atrial Fibrillation Using a Wrist-Worn Device in an Ambulatory Environment.
Poh MZ, Battisti AJ, Cheng LF, Lin J, Patwardhan A, Venkataraman GS, Athill CA, Patel NS, Patel CP, Machado CE, Ellis JT, Crosson LA, Tamura Y, Plowman RS, Turakhia MP, Ghanbari H. Poh MZ, et al. Among authors: patel cp. J Am Heart Assoc. 2023 Oct 3;12(19):e030543. doi: 10.1161/JAHA.123.030543. Epub 2023 Sep 26. J Am Heart Assoc. 2023. PMID: 37750558 Free PMC article.
There is an unmet need for medical-grade diagnostic wrist-worn devices that provide long-term, continuous AF monitoring. METHODS AND RESULTS: We evaluated the performance of a wrist-worn device with lead-I ECG and continuous photoplethysmography (Verily Study Watch) and ph …
There is an unmet need for medical-grade diagnostic wrist-worn devices that provide long-term, continuous AF monitoring. METHODS AND …
Multimodality hemodynamic evaluation for optimizing management of anomalous origin of the right pulmonary artery from the aorta in an adolescent.
Gupta SK, Choubey M, Kumar S, Patel C, Airan B. Gupta SK, et al. Among authors: patel c. Ann Pediatr Cardiol. 2023 Jan-Feb;16(1):65-70. doi: 10.4103/apc.apc_98_22. Epub 2023 Apr 4. Ann Pediatr Cardiol. 2023. PMID: 37287841 Free PMC article.
We also report 5-year hemodynamic data confirming sustained benefit over the long term, thus providing much-needed clinical validation of often cited Poiseuille's and Ohm's laws....
We also report 5-year hemodynamic data confirming sustained benefit over the long term, thus providing much-needed clinical validatio …
PHOTORECEPTOR DAMAGE IN TERSON SYNDROME.
Szeligowski T, Fu DJ, Fernandez-Ledo N, Birtel J, Aslam SA, Patel CK, Xue K, Charbel Issa P. Szeligowski T, et al. Among authors: patel ck. Retina. 2023 Sep 1;43(9):1557-1562. doi: 10.1097/IAE.0000000000003842. Retina. 2023. PMID: 37253246
The observed retinal abnormalities demonstrated incomplete recovery over long-term follow-up 3.5 to 8 years posthemorrhage, irrespective of surgical or conservative treatment strategy, and had variable impact on the patients' visual function. ...
The observed retinal abnormalities demonstrated incomplete recovery over long-term follow-up 3.5 to 8 years posthemorrhage, irrespect …
148 results