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Mapping cell-to-tissue graphs across human placenta histology whole slide images using deep learning with HAPPY.
Vanea C, Džigurski J, Rukins V, Dodi O, Siigur S, Salumäe L, Meir K, Parks WT, Hochner-Celnikier D, Fraser A, Hochner H, Laisk T, Ernst LM, Lindgren CM, Nellåker C. Vanea C, et al. Among authors: parks wt. Nat Commun. 2024 Mar 28;15(1):2710. doi: 10.1038/s41467-024-46986-2. Nat Commun. 2024. PMID: 38548713 Free PMC article.
HAPPY differs from patch-based features or segmentation approaches by following an interpretable biological hierarchy, representing cells and cellular communities within tissues at a single-cell resolution across whole slide images. We present a set of quantitative metrics from h …
HAPPY differs from patch-based features or segmentation approaches by following an interpretable biological hierarchy, representing cells an …
Integrated unbiased multiomics defines disease-independent placental clusters in common obstetrical syndromes.
Barak O, Lovelace T, Piekos S, Chu T, Cao Z, Sadovsky E, Mouillet JF, Ouyang Y, Parks WT, Hood L, Price ND, Benos PV, Sadovsky Y. Barak O, et al. Among authors: parks wt. BMC Med. 2023 Sep 8;21(1):349. doi: 10.1186/s12916-023-03054-8. BMC Med. 2023. PMID: 37679695 Free PMC article.
METHODS: Using our extensive biobank, we identified women with severe PE (n = 75), FGR (n = 40), FGR with a hypertensive disorder (FGR + HDP; n = 33), sPTD (n = 72), and two uncomplicated control groups, term (n = 113), and preterm without PE, FGR, or sPTD (n = 16). We use …
METHODS: Using our extensive biobank, we identified women with severe PE (n = 75), FGR (n = 40), FGR with a hypertensive disorder (FGR + HDP …
Prepregnancy obesity and risk of placental inflammation at term: a selection bias analysis.
Layden AJ, Bertolet M, Parks WT, Adibi JJ, Roberts JM, Catov JM. Layden AJ, et al. Among authors: parks wt. Ann Epidemiol. 2023 Oct;86:25-33.e7. doi: 10.1016/j.annepidem.2023.06.003. Epub 2023 Jun 10. Ann Epidemiol. 2023. PMID: 37302673
We examine the association between prepregnancy obesity (risk factor for inflammation) and histologic placental inflammation (correlated with impaired infant neurodevelopment) and how selection bias may influence the association. METHODS: Singleton term deliveries between …
We examine the association between prepregnancy obesity (risk factor for inflammation) and histologic placental inflammation (correlated wit …
Association of Hypertensive Disorders of Pregnancy With Left Ventricular Remodeling Later in Life.
Countouris ME, Villanueva FS, Berlacher KL, Cavalcante JL, Parks WT, Catov JM. Countouris ME, et al. Among authors: parks wt. J Am Coll Cardiol. 2021 Mar 2;77(8):1057-1068. doi: 10.1016/j.jacc.2020.12.051. J Am Coll Cardiol. 2021. PMID: 33632480 Free PMC article.
BACKGROUND: Hypertensive disorders of pregnancy (HDP) are associated with short-term cardiac structure and function abnormalities, but later life changes are not well studied. ...
BACKGROUND: Hypertensive disorders of pregnancy (HDP) are associated with short-term cardiac structure and function abnormalities, bu …
Early pregnancy immune profile and preterm birth classified according to uteroplacental lesions.
Sun B, Parks WT, Simhan HN, Bertolet M, Catov JM. Sun B, et al. Among authors: parks wt. Placenta. 2020 Jan 1;89:99-106. doi: 10.1016/j.placenta.2019.12.007. Epub 2019 Dec 10. Placenta. 2020. PMID: 32056560 Free article.
METHODS: Women from a hospital-based cohort (2008-2012, n = 397) were randomly selected within 6 strata of term and preterm birth with and without placental decidual vasculopathy (arteriopathy), intrauterine inflammation/infection (acute chorioamnionitis), or no les …
METHODS: Women from a hospital-based cohort (2008-2012, n = 397) were randomly selected within 6 strata of term and preterm birth …
Unique microRNA Signals in Plasma Exosomes from Pregnancies Complicated by Preeclampsia.
Li H, Ouyang Y, Sadovsky E, Parks WT, Chu T, Sadovsky Y. Li H, et al. Among authors: parks wt. Hypertension. 2020 Mar;75(3):762-771. doi: 10.1161/HYPERTENSIONAHA.119.14081. Epub 2020 Jan 27. Hypertension. 2020. PMID: 31983308 Free PMC article.
We tested the hypothesis that preeclampsia may affect the miRNA cargo within circulating maternal blood exosomes. We collected plasma from 60 pregnant women at term, including 20 women with pregnancy complicated by preeclampsia, and 20 women with fetal growth restriction a …
We tested the hypothesis that preeclampsia may affect the miRNA cargo within circulating maternal blood exosomes. We collected plasma from 6 …
Race and risk of maternal vascular malperfusion lesions in the placenta.
Assibey-Mensah V, Parks WT, Gernand AD, Catov JM. Assibey-Mensah V, et al. Among authors: parks wt. Placenta. 2018 Sep;69:102-108. doi: 10.1016/j.placenta.2018.07.017. Epub 2018 Aug 2. Placenta. 2018. PMID: 30213478
RESULTS: After adjusting for covariates, black women had increased risks of MVM (aOR 1.14, 95% CI 1.05-1.23), low placental weight (aOR 1.41, 95% CI 1.28-1.55), and decidual vasculopathy (aOR 1.58, 95% CI 1.36-1.83), also observed in uncomplicated, preterm, and term births …
RESULTS: After adjusting for covariates, black women had increased risks of MVM (aOR 1.14, 95% CI 1.05-1.23), low placental weight (aOR 1.41 …
Preterm birth with placental evidence of malperfusion is associated with cardiovascular risk factors after pregnancy: a prospective cohort study.
Catov JM, Muldoon MF, Reis SE, Ness RB, Nguyen LN, Yamal JM, Hwang H, Parks WT. Catov JM, et al. Among authors: parks wt. BJOG. 2018 Jul;125(8):1009-1017. doi: 10.1111/1471-0528.15040. Epub 2017 Dec 28. BJOG. 2018. PMID: 29193660 Free PMC article.
OBJECTIVE: Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. ...SETTING: Pittsburgh, PA, USA. POPULATION: Women with PTB (n = 115) and term births (n = 210) evaluated 4-12 years after pregnancy. METHODS: Cardiometabolic risk markers …
OBJECTIVE: Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. ...SETTING: Pittsburgh, PA, USA. POPUL …
The Role of Serotonin Transporter in Human Lung Development and in Neonatal Lung Disorders.
Castro EC, Sen P, Parks WT, Langston C, Galambos C. Castro EC, et al. Among authors: parks wt. Can Respir J. 2017;2017:9064046. doi: 10.1155/2017/9064046. Epub 2017 Feb 20. Can Respir J. 2017. PMID: 28316463 Free PMC article.
We found that SERT protein expression begins at 30 weeks of gestation, increases to term, and stays high postnatally. ACD/MPV patients had diminished SERT expression without SERT promoter alteration. ...We concluded that SERT/serotonin pathway is crucial in the process of …
We found that SERT protein expression begins at 30 weeks of gestation, increases to term, and stays high postnatally. ACD/MPV patient …
Neonatal outcomes following preterm birth classified according to placental features.
Catov JM, Scifres CM, Caritis SN, Bertolet M, Larkin J, Parks WT. Catov JM, et al. Among authors: parks wt. Am J Obstet Gynecol. 2017 Apr;216(4):411.e1-411.e14. doi: 10.1016/j.ajog.2016.12.022. Epub 2017 Jan 5. Am J Obstet Gynecol. 2017. PMID: 28065815
BACKGROUND: Preterm birth has staggering health implications, and yet the causes of most cases are still unknown. Placental features have been understudied as an etiology for preterm birth, and the association between placental pathologic lesions and neonatal outcom …
BACKGROUND: Preterm birth has staggering health implications, and yet the causes of most cases are still unknown. Placental features …
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