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Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes.
Seggio M, Contino A, Maccarrone G, Parenti C, Merlo S, Pappalardo G, Giuffrida A, Chiechio S. Seggio M, et al. Among authors: pappalardo g. Int J Pharm. 2019 Jul 20;566:391-399. doi: 10.1016/j.ijpharm.2019.05.077. Epub 2019 May 31. Int J Pharm. 2019. PMID: 31158453
Yet, duloxetine is metabolized by the cytochrome P450 system 2D6 and 1A2 (CYP2D6 and CYP1A2) and it exhibits moderate inhibitory activity on CYP2D6, resulting in side effects and metabolic interactions that may occur on a long term therapeutic schedule. Cyclodextrins (CyDs …
Yet, duloxetine is metabolized by the cytochrome P450 system 2D6 and 1A2 (CYP2D6 and CYP1A2) and it exhibits moderate inhibitory activity on …
Tips to facilitate a preoperative diagnosis of adrenal ganglioneuroma. Report of a challenging experience and review of the literature.
Proposito D, De Lucia F, Giannella A, Frangella F, Pappalardo G, Santangelo M, Magagnano D. Proposito D, et al. Among authors: pappalardo g. Ann Ital Chir. 2016 Feb 10;87:S2239253X16024208. Ann Ital Chir. 2016. PMID: 27595615 Review.
Even if AGN has an excellent prognosis and recurrences are rare after surgical resections, long-term follow-up is recommended. KEY WORDS: Adrenal gland, Adrenal ganglioneuroma, Laparoscopic adrenalectomy, Open adrenalectomy....
Even if AGN has an excellent prognosis and recurrences are rare after surgical resections, long-term follow-up is recommended. KEY WO …
A comparison of the outcome using Ligasure™ small jaw and clamp-and-tie technique in thyroidectomy: a randomized single center study.
Coiro S, Frattaroli FM, De Lucia F, Manna E, Fabi F, Frattaroli JM, Pappalardo G. Coiro S, et al. Among authors: pappalardo g. Langenbecks Arch Surg. 2015 Feb;400(2):247-52. doi: 10.1007/s00423-014-1270-y. Epub 2015 Jan 13. Langenbecks Arch Surg. 2015. PMID: 25582310 Clinical Trial.
This study evaluates the effects of employment of a recently introduced device (LigaSure Small Jaw, LSJ), compared to the traditional clamp-and-tie (CT) technique, on the short- and long-term outcome of the patients who underwent thyroidectomy. METHODS: This prospective, r …
This study evaluates the effects of employment of a recently introduced device (LigaSure Small Jaw, LSJ), compared to the traditional clamp- …
Italian cancer figures, report 2012: Cancer in children and adolescents.
AIRTUM Working Group; CCM; AIEOP Working Group. AIRTUM Working Group, et al. Epidemiol Prev. 2013 Jan-Feb;37(1 Suppl 1):1-225. Epidemiol Prev. 2013. PMID: 23585445 Free article. English, Italian.
Health organizational aspects of treatment services for paediatric patients, based on the AIEOP database, are also discussed, along with long-term complications in cured patients. The third section describes the changes in mortality trends due to improving therapies and he …
Health organizational aspects of treatment services for paediatric patients, based on the AIEOP database, are also discussed, along with lon …
Italian cancer figures, report 2010: Cancer prevalence in Italy. Patients living with cancer, long-term survivors and cured patients.
AIRTUM Working Group. AIRTUM Working Group. Epidemiol Prev. 2010 Sep-Dec;34(5-6 Suppl 2):1-188. Epidemiol Prev. 2010. PMID: 21220827 Free article. English, Italian.
OBJECTIVES: the aim of the present monograph is to update the estimation of the number of people living with cancer in Italy, to describe geographic variability, and estimate the number of long-term survivors, i.e., people living five years or more after a cancer diagnosis …
OBJECTIVES: the aim of the present monograph is to update the estimation of the number of people living with cancer in Italy, to describe ge …
Accumulation and interactions of beta-carotene and alpha-tocopherol in patients with adenomatous polyps.
Simone F, Pappalardo G, Maiani G, Guadalaxara A, Bugianesi R, Conte AM, Azzini E, Mobarhan S. Simone F, et al. Among authors: pappalardo g. Eur J Clin Nutr. 2002 Jun;56(6):546-50. doi: 10.1038/sj.ejcn.1601354. Eur J Clin Nutr. 2002. PMID: 12032655 Clinical Trial.
OBJECTIVE: The aims of the present study were: (1) to determine whether short-term supplementation of beta-carotene (BC) or vitamin E (VE; alpha-tocopherol) would result in their respective accumulation in normal colonic mucosa and in adenomatous polyps; (2) to determine w …
OBJECTIVE: The aims of the present study were: (1) to determine whether short-term supplementation of beta-carotene (BC) or vitamin E …
Long-term results of Roux-en-Y hepaticojejunostomy and hepaticojejunoduodenostomy.
Pappalardo G, Correnti S, Mobarhan S, Trentino P, Pietropaolo A, Frattaroli F, Castrini G. Pappalardo G, et al. Ann Surg. 1982 Aug;196(2):149-52. doi: 10.1097/00000658-198208000-00006. Ann Surg. 1982. PMID: 7092365 Free PMC article.
The results of the long-term follow-up of 202 patients with Roux-en-Y hepaticojejunostomy (Roux-en-Y HJ) and 19 with hepaticojejunoduodenostomy (HJD) are reported. ...
The results of the long-term follow-up of 202 patients with Roux-en-Y hepaticojejunostomy (Roux-en-Y HJ) and 19 with hepaticojejunodu …