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1981 1
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2005 2
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Page 1
Optimizing the ongoing search for new treatments for Parkinson disease: using futility designs.
Tilley BC, Palesch YY, Kieburtz K, Ravina B, Huang P, Elm JJ, Shannon K, Wooten GF, Tanner CM, Goetz GC; NET-PD Investigators. Tilley BC, et al. Among authors: palesch yy. Neurology. 2006 Mar 14;66(5):628-33. doi: 10.1212/01.wnl.0000201251.33253.fb. Neurology. 2006. PMID: 16534099 Review.
Given the large number of agents and the limited resources to evaluate new agents, it is essential to reduce the likelihood of advancing ineffective agents into large, long-term Phase III trials. Futility design methodology addresses this goal. The authors describe how a s …
Given the large number of agents and the limited resources to evaluate new agents, it is essential to reduce the likelihood of advancing ine …
Long-term follow-up of absence seizures.
Sato S, Dreifuss FE, Penry JK, Kirby DD, Palesch Y. Sato S, et al. Among authors: palesch y. Neurology. 1983 Dec;33(12):1590-5. doi: 10.1212/wnl.33.12.1590. Neurology. 1983. PMID: 6417557
National Institutes of Health Stroke Scale: An Alternative Primary Outcome Measure for Trials of Acute Treatment for Ischemic Stroke.
Chalos V, van der Ende NAM, Lingsma HF, Mulder MJHL, Venema E, Dijkland SA, Berkhemer OA, Yoo AJ, Broderick JP, Palesch YY, Yeatts SD, Roos YBWEM, van Oostenbrugge RJ, van Zwam WH, Majoie CBLM, van der Lugt A, Roozenbeek B, Dippel DWJ; MR CLEAN Investigators. Chalos V, et al. Among authors: palesch yy. Stroke. 2020 Jan;51(1):282-290. doi: 10.1161/STROKEAHA.119.026791. Epub 2019 Dec 4. Stroke. 2020. PMID: 31795895 Free PMC article. Clinical Trial.
Background and Purpose- The modified Rankin Scale (mRS) at 3 months is the most commonly used primary outcome measure in stroke treatment trials, but it lacks specificity and requires long-term follow-up interviews, which consume time and resources. An alternative may be t …
Background and Purpose- The modified Rankin Scale (mRS) at 3 months is the most commonly used primary outcome measure in stroke treatment tr …
Using global statistical tests in long-term Parkinson's disease clinical trials.
Huang P, Goetz CG, Woolson RF, Tilley B, Kerr D, Palesch Y, Elm J, Ravina B, Bergmann KJ, Kieburtz K; Parkinson Study Group. Huang P, et al. Among authors: palesch y. Mov Disord. 2009 Sep 15;24(12):1732-9. doi: 10.1002/mds.22645. Mov Disord. 2009. PMID: 19514076 Free PMC article.
Parkinson's disease (PD) impairments are multidimensional, making it difficult to choose a single primary outcome when evaluating treatments to stop or lessen the long-term decline in PD. We review commonly used multivariate statistical methods for assessing a treatment's …
Parkinson's disease (PD) impairments are multidimensional, making it difficult to choose a single primary outcome when evaluating treatments …
Risk for Major Hemorrhages in Patients Receiving Clopidogrel and Aspirin Compared With Aspirin Alone After Transient Ischemic Attack or Minor Ischemic Stroke: A Secondary Analysis of the POINT Randomized Clinical Trial.
Tillman H, Johnston SC, Farrant M, Barsan W, Elm JJ, Kim AS, Lindblad AS, Palesch YY, Easton JD. Tillman H, et al. Among authors: palesch yy. JAMA Neurol. 2019 Jul 1;76(7):774-782. doi: 10.1001/jamaneurol.2019.0932. JAMA Neurol. 2019. PMID: 31034032 Free PMC article. Clinical Trial.
IMPORTANCE: Results show the short-term risk of hemorrhage in treating patients with acute transient ischemic attack (TIA) or minor acute ischemic stroke (AIS) with clopidogrel plus aspirin or aspirin alone. ...
IMPORTANCE: Results show the short-term risk of hemorrhage in treating patients with acute transient ischemic attack (TIA) or minor a …
Non-linearity of Parkinson's disease progression: implications for sample size calculations in clinical trials.
Guimaraes P, Kieburtz K, Goetz CG, Elm JJ, Palesch YY, Huang P, Ravina B, Tanner CM, Tilley BC. Guimaraes P, et al. Among authors: palesch yy. Clin Trials. 2005;2(6):509-18. doi: 10.1191/1740774505cn125oa. Clin Trials. 2005. PMID: 16422311
BACKGROUND: Estimation of sample size for long-term studies of neuroprotection in Parkinson's disease requires information on expected clinical decline. Values may be obtained by analyzing existing long-term data sets or by prediction models of clinical decline appl …
BACKGROUND: Estimation of sample size for long-term studies of neuroprotection in Parkinson's disease requires information on expecte …
Observed Cost and Variations in Short Term Cost-Effectiveness of Therapy for Ischemic Stroke in Interventional Management of Stroke (IMS) III.
Simpson KN, Simpson AN, Mauldin PD, Palesch YY, Yeatts SD, Kleindorfer D, Tomsick TA, Foster LD, Demchuk AM, Khatri P, Hill MD, Jauch EC, Jovin TG, Yan B, von Kummer R, Molina CA, Goyal M, Schonewille WJ, Mazighi M, Engelter ST, Anderson C, Spilker J, Carrozzella J, Ryckborst KJ, Janis LS, Broderick JP; Interventional Management of Stroke (IMS) III Investigators. Simpson KN, et al. Among authors: palesch yy. J Am Heart Assoc. 2017 May 8;6(5):e004513. doi: 10.1161/JAHA.116.004513. J Am Heart Assoc. 2017. PMID: 28483774 Free PMC article. Clinical Trial.
The kind of resources used postdischarge also varied between treatment groups. Incremental short-term cost-effectiveness ratios varied greatly when treatments were compared for patient subgroups. ...
The kind of resources used postdischarge also varied between treatment groups. Incremental short-term cost-effectiveness ratios varie …
Effect of combined aspirin and extended-release dipyridamole versus clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PRoFESS subgroup analysis.
Bath PM, Cotton D, Martin RH, Palesch Y, Yusuf S, Sacco R, Diener HC, Estol C, Roberts R; PRoFESS Study Group. Bath PM, et al. Among authors: palesch y. Stroke. 2010 Apr;41(4):732-8. doi: 10.1161/STROKEAHA.109.564906. Epub 2010 Feb 24. Stroke. 2010. PMID: 20181679 Clinical Trial.
BACKGROUND AND PURPOSE: Long-term antiplatelet therapy is effective at reducing recurrence after ischemic stroke. ...
BACKGROUND AND PURPOSE: Long-term antiplatelet therapy is effective at reducing recurrence after ischemic stroke. ...
A responsive outcome for Parkinson's disease neuroprotection futility studies.
Elm JJ, Goetz CG, Ravina B, Shannon K, Wooten GF, Tanner CM, Palesch YY, Huang P, Guimaraes P, Kamp C, Tilley BC, Kieburtz K; NET-PD Investigators. Elm JJ, et al. Among authors: palesch yy. Ann Neurol. 2005 Feb;57(2):197-203. doi: 10.1002/ana.20361. Ann Neurol. 2005. PMID: 15668964
Futility studies are designed to test new treatments over a short period in a small number of subjects to determine if those treatments are worthy of larger and longer term studies, or if they should be abandoned. An appropriate outcome measure for a neuroprotection futili …
Futility studies are designed to test new treatments over a short period in a small number of subjects to determine if those treatments are …
The nursing home population: different perspectives and implications for policy.
Liu K, Palesch Y. Liu K, et al. Among authors: palesch y. Health Care Financ Rev. 1981 Dec;3(2):15-23. Health Care Financ Rev. 1981. PMID: 10309556 Free PMC article.
Long-term care institutions are used by residential patients who stay for many years and patients with specific ailments who stay for relatively short periods. ...
Long-term care institutions are used by residential patients who stay for many years and patients with specific ailments who stay for …