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Page 1
Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections.
Greenwood EJ, Schmidt F, Kondova I, Niphuis H, Hodara VL, Clissold L, McLay K, Guerra B, Redrobe S, Giavedoni LD, Lanford RE, Murthy KK, Rouet F, Heeney JL. Greenwood EJ, et al. PLoS Pathog. 2015 Sep 11;11(9):e1005146. doi: 10.1371/journal.ppat.1005146. eCollection 2015 Sep. PLoS Pathog. 2015. PMID: 26360709 Free PMC article.
Previously, the natural SIVcpz infection of one chimpanzee, and the experimental infection of six chimpanzees was reported, with limited follow-up. Here, we present a long-term study of these seven animals, with a retrospective re-examination of the early stages of infecti …
Previously, the natural SIVcpz infection of one chimpanzee, and the experimental infection of six chimpanzees was reported, with limited fol …
GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees.
Lanford RE, Guerra B, Chavez D, Giavedoni L, Hodara VL, Brasky KM, Fosdick A, Frey CR, Zheng J, Wolfgang G, Halcomb RL, Tumas DB. Lanford RE, et al. Gastroenterology. 2013 Jun;144(7):1508-17, 1517.e1-10. doi: 10.1053/j.gastro.2013.02.003. Epub 2013 Feb 13. Gastroenterology. 2013. PMID: 23415804 Free PMC article.
Clinical pathology parameters were monitored to determine the safety and tolerability of GS-9620. RESULTS: Short-term oral administration of GS-9620 provided long-term suppression of serum and liver HBV DNA. ...
Clinical pathology parameters were monitored to determine the safety and tolerability of GS-9620. RESULTS: Short-term oral administra …
Repeated courses of antenatal corticosteroids have adverse effects on aspects of brain development in naturally delivered baboon infants.
Shields A, Thomson M, Winter V, Coalson J, Rees S. Shields A, et al. Pediatr Res. 2012 Jun;71(6):661-7. doi: 10.1038/pr.2012.18. Epub 2012 Feb 14. Pediatr Res. 2012. PMID: 22436975 Free PMC article.
METHODS: Single-course animals received a 6-mg dose of steroids at 123 and 124 d of gestation (dg; term, 185 dg; n = 6). Repeated-course animals received additional doses at 137 and 138 dg (n = 7). Controls received no steroids (n = 5). Baboons delivered naturally at te …
METHODS: Single-course animals received a 6-mg dose of steroids at 123 and 124 d of gestation (dg; term, 185 dg; n = 6). Repeated-cou …
Neuronal damage in the preterm baboon: impact of the mode of ventilatory support.
Verney C, Rees S, Biran V, Thompson M, Inder T, Gressens P. Verney C, et al. J Neuropathol Exp Neurol. 2010 May;69(5):473-82. doi: 10.1097/NEN.0b013e3181dac07b. J Neuropathol Exp Neurol. 2010. PMID: 20418779 Free PMC article.
In the first series, baboons (n = 5) were delivered at 125 days of gestation (dg; term, 185 days) and exposed to 14 days of positive pressure ventilation (PPV) and compared with 140 dg controls (n = 6). ...
In the first series, baboons (n = 5) were delivered at 125 days of gestation (dg; term, 185 days) and exposed to 14 days of positive …
Complications of umbilical artery catheterization in a model of extreme prematurity.
McAdams RM, Winter VT, McCurnin DC, Coalson JJ. McAdams RM, et al. J Perinatol. 2009 Oct;29(10):685-92. doi: 10.1038/jp.2009.73. Epub 2009 Jun 25. J Perinatol. 2009. PMID: 19554012 Free PMC article.
Animals were assigned to short-term (6 days, n=6) and long-term (14 days, n=30) UAC placement. At necropsy, aortas were removed with UACs still in place. ...RESULT: All 6 animals with short-term (6/6, 100%) and 18 animals with long-term (18/30, 60%) UA …
Animals were assigned to short-term (6 days, n=6) and long-term (14 days, n=30) UAC placement. At necropsy, aortas were remove …
Methods for the production of helper-dependent adenoviral vectors.
Palmer DJ, Ng P. Palmer DJ, et al. Methods Mol Biol. 2008;433:33-53. doi: 10.1007/978-1-59745-237-3_3. Methods Mol Biol. 2008. PMID: 18679616
Helper-dependent adenoviral vectors (HDAd) are deleted of all viral coding sequences and have demonstrated tremendous potential for gene therapy by providing long-term, high-level transgene expression in the absence of chronic toxicity. Thus, HDAd are superior to early gen …
Helper-dependent adenoviral vectors (HDAd) are deleted of all viral coding sequences and have demonstrated tremendous potential for gene the …
The ductus venosus and intrahepatic venous system in Callithrix jacchus jacchus and Macaca fascicularis fetuses.
Tchirikov M, Schlabritz-Loutsevitch NE, Hubbard GB, Tardif S, Schröder HJ, Nathanielsz PW. Tchirikov M, et al. J Med Primatol. 2006 Feb;35(1):18-24. doi: 10.1111/j.1600-0684.2005.00142.x. J Med Primatol. 2006. PMID: 16430491
METHODS: Morphological investigations were performed on eight marmoset (Callithrix jacchus jacchus) at 112.5 +/- 5.5 days gestational age (mean +/- SEM) and four near-term (165 days) cynomolgus (Macaca fascicularis) fetuses. RESULTS: The DV drains into the collectus venosu …
METHODS: Morphological investigations were performed on eight marmoset (Callithrix jacchus jacchus) at 112.5 +/- 5.5 days gestational age (m …
Endocrine changes in full-term pregnancies and pregnancy loss due to energy restriction in the common marmoset (Callithrix jacchus).
Tardif SD, Ziegler TE, Power M, Layne DG. Tardif SD, et al. J Clin Endocrinol Metab. 2005 Jan;90(1):335-9. doi: 10.1210/jc.2004-1064. Epub 2004 Oct 13. J Clin Endocrinol Metab. 2005. PMID: 15483089
Within female marmosets, comparisons (n = 6) between a normal, term pregnancy and a restriction-induced aborted pregnancy were used to establish cortisol, free estradiol, and chorionic gonadotropin (CG) as urinary markers of placental and fetal function under these two con …
Within female marmosets, comparisons (n = 6) between a normal, term pregnancy and a restriction-induced aborted pregnancy were used t …
Treatment of immature baboons for 28 days with early nasal continuous positive airway pressure.
Thomson MA, Yoder BA, Winter VT, Martin H, Catland D, Siler-Khodr TM, Coalson JJ. Thomson MA, et al. Am J Respir Crit Care Med. 2004 May 1;169(9):1054-62. doi: 10.1164/rccm.200309-1276OC. Epub 2004 Feb 12. Am J Respir Crit Care Med. 2004. PMID: 14962819
Using the 125-day baboon model of long-term bronchopulmonary dysplasia, we hypothesized that early use of nasal continuous positive airway pressure (nCPAP), a noninvasive ventilatory method, combined with prophylactic surfactant therapy would permit continuation of alveola …
Using the 125-day baboon model of long-term bronchopulmonary dysplasia, we hypothesized that early use of nasal continuous positive a …
The baboon as a nonhuman primate model for the study of the genetics of obesity.
Comuzzie AG, Cole SA, Martin L, Carey KD, Mahaney MC, Blangero J, VandeBerg JL. Comuzzie AG, et al. Obes Res. 2003 Jan;11(1):75-80. doi: 10.1038/oby.2003.12. Obes Res. 2003. PMID: 12529488 Free article.
RESEARCH METHODS AND PROCEDURES: At present, we are collecting extensive phenotypic data in a large pedigreed colony (N > 2000) of baboons housed at the Southwest Foundation for Biomedical Research in San Antonio, Texas. The long-term goal of this project is to identify …
RESEARCH METHODS AND PROCEDURES: At present, we are collecting extensive phenotypic data in a large pedigreed colony (N > 2000) of baboon …