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DREADD-mediated amygdala activation is sufficient to induce anxiety-like responses in young nonhuman primates.
Mueller SAL, Oler JA, Roseboom PH, Aggarwal N, Kenwood MM, Riedel MK, Elam VR, Olsen ME, DiFilippo AH, Christian BT, Hu X, Galvan A, Boehm MA, Michaelides M, Kalin NH. Mueller SAL, et al. Curr Res Neurobiol. 2023 Oct 5;5:100111. doi: 10.1016/j.crneur.2023.100111. eCollection 2023. Curr Res Neurobiol. 2023. PMID: 38020807 Free PMC article.
This effect was again observed approximately 1.9 years following surgery, indicating the long-term functional capacity of DREADD-induced neuronal activation. [(11)C]deschloroclozapine PET imaging demonstrated amygdala hM3Dq-HA specific binding, and immunohistochemistry rev …
This effect was again observed approximately 1.9 years following surgery, indicating the long-term functional capacity of DREADD-indu …
DREADD-mediated amygdala activation is sufficient to induce anxiety-like responses in young nonhuman primates.
Mueller SAL, Oler JA, Roseboom PH, Aggarwal N, Kenwood MM, Riedel MK, Elam VR, Olsen ME, DiFilippo AH, Christian BT, Hu X, Galvan A, Boehm MA, Michaelides M, Kalin NH. Mueller SAL, et al. bioRxiv [Preprint]. 2023 Jun 7:2023.06.06.543911. doi: 10.1101/2023.06.06.543911. bioRxiv. 2023. PMID: 37333300 Free PMC article. Updated. Preprint.
This effect was again observed approximately 1.9 years following surgery, indicating the long-term functional capacity of DREADD-induced neuronal activation. [(11)C]deschloroclozapine PET imaging demonstrated amygdala hM3Dq-HA specific binding, and immunohistochemistry rev …
This effect was again observed approximately 1.9 years following surgery, indicating the long-term functional capacity of DREADD-indu …
Development of an anti-CAR antibody response in SIV-infected rhesus macaques treated with CD4-MBL CAR/CXCR5 T cells.
Davey BC, Pampusch MS, Cartwright EK, Abdelaal HM, Rakasz EG, Rendahl A, Berger EA, Skinner PJ. Davey BC, et al. Front Immunol. 2022 Dec 13;13:1032537. doi: 10.3389/fimmu.2022.1032537. eCollection 2022. Front Immunol. 2022. PMID: 36582226 Free PMC article.
While in our study, there was no statistically significant correlation between the ADA response and the persistence of the CD4-MBL CAR/CXCR5-T cells in rhesus macaques, these findings suggest that the development of an ADA response could impact the long-term persistence of …
While in our study, there was no statistically significant correlation between the ADA response and the persistence of the CD4-MBL CAR/CXCR5 …
Nonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety.
Kenwood MM, Kalin NH. Kenwood MM, et al. Biol Psychiatry. 2021 Apr 1;89(7):659-671. doi: 10.1016/j.biopsych.2020.08.028. Epub 2020 Sep 12. Biol Psychiatry. 2021. PMID: 33229035 Free PMC article. Review.
Characterization of our NHP model of behavioral inhibition, which we term anxious temperament (AT), reveals that it is trait-like. Exploration of the neural substrates of AT in NHPs has revealed a distributed neural circuit that is linked to individual differences in AT, w …
Characterization of our NHP model of behavioral inhibition, which we term anxious temperament (AT), reveals that it is trait-like. Ex …
Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV.
Martinez-Navio JM, Fuchs SP, Mendes DE, Rakasz EG, Gao G, Lifson JD, Desrosiers RC. Martinez-Navio JM, et al. Front Immunol. 2020 Mar 17;11:449. doi: 10.3389/fimmu.2020.00449. eCollection 2020. Front Immunol. 2020. PMID: 32256496 Free PMC article.
Long-term delivery of anti-HIV monoclonal antibodies using adeno-associated virus (AAV) holds promise for the prevention and treatment of HIV infection. ...
Long-term delivery of anti-HIV monoclonal antibodies using adeno-associated virus (AAV) holds promise for the prevention and treatmen …
Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys.
Fuchs SP, Martinez-Navio JM, Rakasz EG, Gao G, Desrosiers RC. Fuchs SP, et al. Mol Ther Methods Clin Dev. 2019 Nov 26;16:94-102. doi: 10.1016/j.omtm.2019.11.010. eCollection 2020 Mar 13. Mol Ther Methods Clin Dev. 2019. PMID: 31890736 Free PMC article.
Anti-drug antibodies (ADAs) have been frequently observed, and long-term AAV-mediated delivery has been inconsistent. Here, we investigated different AAV vector strategies and delivery schemes to rhesus monkeys using the rhesus monkey mAb 4L6. ...Our results suggest that l …
Anti-drug antibodies (ADAs) have been frequently observed, and long-term AAV-mediated delivery has been inconsistent. Here, we invest …
Quantitative Ultrasound Parameters Based on the Backscattered Echo Power Signal as Biomarkers of Cervical Remodeling: A Longitudinal Study in the Pregnant Rhesus Macaque.
Guerrero QW, Feltovich H, Rosado-Mendez IM, Santoso AP, Carlson LC, Zea R, Hall TJ. Guerrero QW, et al. Ultrasound Med Biol. 2019 Jun;45(6):1466-1474. doi: 10.1016/j.ultrasmedbio.2018.12.004. Epub 2019 Apr 9. Ultrasound Med Biol. 2019. PMID: 30979594 Free PMC article.
Clinical prediction and especially prevention of abnormal birth timing, particularly pre-term, is poor. The cervix plays a key role in birth timing; it first serves as a rigid barrier to protect the developing fetus, then becomes the pathway to delivery of th …
Clinical prediction and especially prevention of abnormal birth timing, particularly pre-term, is poor. The cervix plays a key …
Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression.
Martinez-Navio JM, Fuchs SP, Pantry SN, Lauer WA, Duggan NN, Keele BF, Rakasz EG, Gao G, Lifson JD, Desrosiers RC. Martinez-Navio JM, et al. Immunity. 2019 Mar 19;50(3):567-575.e5. doi: 10.1016/j.immuni.2019.02.005. Epub 2019 Mar 5. Immunity. 2019. PMID: 30850342 Free PMC article.
Long-term delivery of anti-HIV monoclonal antibodies (mAbs) using adeno-associated virus (AAV) vectors holds promise for the prevention and treatment of HIV infection. ...
Long-term delivery of anti-HIV monoclonal antibodies (mAbs) using adeno-associated virus (AAV) vectors holds promise for the preventi …
Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication.
Haran KP, Hajduczki A, Pampusch MS, Mwakalundwa G, Vargas-Inchaustegui DA, Rakasz EG, Connick E, Berger EA, Skinner PJ. Haran KP, et al. Front Immunol. 2018 Mar 20;9:492. doi: 10.3389/fimmu.2018.00492. eCollection 2018. Front Immunol. 2018. PMID: 29616024 Free PMC article.
We hypothesize that antiviral CAR/CXCR5-expressing T cells, when infused into an SIV-infected animal or an HIV-infected individual, will home to B cell follicles, suppress viral replication, and lead to long-term durable remission of SIV and HIV. To begin to test this hypo …
We hypothesize that antiviral CAR/CXCR5-expressing T cells, when infused into an SIV-infected animal or an HIV-infected individual, will hom …
Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study.
Yamada Y, Kemnitz JW, Weindruch R, Anderson RM, Schoeller DA, Colman RJ. Yamada Y, et al. J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):273-278. doi: 10.1093/gerona/glx059. J Gerontol A Biol Sci Med Sci. 2018. PMID: 28398464 Free PMC article.
Recently, greater emphasis has been placed on healthy life span and preventing frailty than on longevity. Here, we show the beneficial effect of long-term calorie restriction on frailty in later life in a nonhuman primate. ...
Recently, greater emphasis has been placed on healthy life span and preventing frailty than on longevity. Here, we show the beneficial effec …
53 results