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Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with X-linked myotubular myopathy.
Lawlor MW, Armstrong D, Viola MG, Widrick JJ, Meng H, Grange RW, Childers MK, Hsu CP, O'Callaghan M, Pierson CR, Buj-Bello A, Beggs AH. Lawlor MW, et al. Hum Mol Genet. 2013 Apr 15;22(8):1525-38. doi: 10.1093/hmg/ddt003. Epub 2013 Jan 9. Hum Mol Genet. 2013. PMID: 23307925 Free PMC article.
Mtm1 p.R69C mice, which produce small amounts of myotubularin, showed impaired contractile function only in EDL muscles. Short-term replacement of myotubularin with a prototypical targeted protein replacement agent (3E10Fv-MTM1) in Mtm1delta4 mice improved contractile func …
Mtm1 p.R69C mice, which produce small amounts of myotubularin, showed impaired contractile function only in EDL muscles. Short-term r …
Targeting CD22 reprograms B-cells and reverses autoimmune diabetes.
Fiorina P, Vergani A, Dada S, Jurewicz M, Wong M, Law K, Wu E, Tian Z, Abdi R, Guleria I, Rodig S, Dunussi-Joannopoulos K, Bluestone J, Sayegh MH. Fiorina P, et al. Diabetes. 2008 Nov;57(11):3013-24. doi: 10.2337/db08-0420. Epub 2008 Aug 8. Diabetes. 2008. PMID: 18689692 Free PMC article.
Importantly, when new-onset hyperglycemic mice were treated with the anti-CD22/cal mAb, 100% of B-cell-depleted mice became normoglycemic by 2 days, and 70% of them maintained a state of long-term normoglycemia. Early therapy after onset of hyperglycemia and complete B-cel …
Importantly, when new-onset hyperglycemic mice were treated with the anti-CD22/cal mAb, 100% of B-cell-depleted mice became normoglycemic by …
Reproducibility of gene expression across generations of Affymetrix microarrays.
Nimgaonkar A, Sanoudou D, Butte AJ, Haslett JN, Kunkel LM, Beggs AH, Kohane IS. Nimgaonkar A, et al. BMC Bioinformatics. 2003 Jun 25;4:27. doi: 10.1186/1471-2105-4-27. Epub 2003 Jun 25. BMC Bioinformatics. 2003. PMID: 12823866 Free PMC article.
Although the ability to compare datasets across generations is crucial for any long-term research project, to date no means to allow such comparisons have been developed. ...
Although the ability to compare datasets across generations is crucial for any long-term research project, to date no means to allow …